Resting-state functional changes in the precuneus within first-episode drug-naive patients with MDD

Li, Gaizhi; Rossbach, Kathryn; Zhang, Aixia; Liu, Penghong; Zhang, Kerang

doi:10.2147/ndt.s168060

Cited by 42 publications

(33 citation statements)

References 28 publications

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“…As advocated in many meditation traditions, a greater present-centered awareness is finally achieved by transforming the view of the self (Fox et al, 2014). The precuneus has consistently been reported to be dysregulated in depression (Li et al, 2018). The role it plays in emotion regulation should be further studied.…”

Section: Discussionmentioning

confidence: 99%

Alterations of Regional Homogeneity and Functional Connectivity Following Short-Term Mindfulness Meditation in Healthy Volunteers

Xiao

Zhao

et al. 2019

Front. Hum. Neurosci.

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Mindfulness is described as the non-judgmental awareness of experiences in the present moment. The sustained practice of mindfulness may also have beneficial effects on an individual’s well-being. For instance, mindfulness meditation is an effective approach for improving emotion regulation. Specifically, the early stage of mindfulness meditation training enhances emotional monitoring systems related to attention regulation and executive function. Reduced activity in the default mode network (DMN) would probably be observed corresponding to the attenuated mind wandering. In the present study, we hypothesized that alterations in functional activity in the frontal-parietal cortex and DMN may be induced by short-term mindfulness meditation. In this study, before and after 8 weeks of weekly Mindfulness-Based Stress Reduction (MBSR) training, healthy participants were evaluated using a mindfulness questionnaire and an affect schedule, as well as via resting-state functional magnetic resonance imaging. Sixteen right-handed non-meditators were enrolled. Another 16 demographically matched healthy adults without any meditation experience were recruited as controls. Pre- and post-MBSR assessments were compared. Increased regional homogeneity in the right superior parietal lobule and left postcentral gyrus (PoCG), as well as altered functional connectivity in PoCG-related networks, were observed post-MBSR. The mindfulness questionnaire scores also improved and negative affect was significantly decreased after MBSR. Together with reduced involvement of the posterior brain, our results suggest a tendency toward stronger involvement of the parietal cortex in mindfulness beginners. This study provides novel evidence regarding the optimization of emotional processing with short-term mindfulness meditation.

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Section: Discussionmentioning

confidence: 99%

Alterations of Regional Homogeneity and Functional Connectivity Following Short-Term Mindfulness Meditation in Healthy Volunteers

Xiao

Zhao

et al. 2019

Front. Hum. Neurosci.

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“…The links in this brain subsystem were mainly long-distance correlations between regions of the DM network and regions outside the DM network, with the right precuneus accounting for the largest number of them. The precuneus, as a core component of the DM network (Utevsky et al, 2014 but see also Margulies et al, 2009) may be important for self-referential processing (Fransson and Marrelec, 2008;Van Buuren et al, 2010) and has been commonly described with aberrant resting-state activity (Liu C.-H. et al, 2017;Li et al, 2018) and connectivity in patients with depression (Zhu et al, 2012;Dutta et al, 2019;Jacob et al, 2020). The study by Jacob et al (2020) found reduced strength connectivity of this region to be linked to higher rumination tendency (i.e., an exaggerated focus on negative thoughts) in patients with depression.…”

Section: The Precuneus Accounts For the Overall Reduced Static Fc In mentioning

confidence: 99%

The Dynamics of Functional Brain Networks Associated With Depressive Symptoms in a Nonclinical Sample

Alonso

Deco

Horst

et al. 2020

Front. Neural Circuits

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Brain function depends on the flexible and dynamic coordination of functional subsystems within distributed neural networks operating on multiple scales. Recent progress has been made in the characterization of functional connectivity (FC) at the whole-brain scale from a dynamic, rather than static, perspective, but its validity for cognitive sciences remains under debate. Here, we analyzed brain activity recorded with functional Magnetic Resonance Imaging from 71 healthy participants evaluated for depressive symptoms after a relationship breakup based on the conventional Major Depression Inventory (MDI). We compared both static and dynamic FC patterns between participants reporting high and low depressive symptoms. Between-group differences in static FC were estimated using a standard pipeline for networkbased statistic (NBS). Additionally, FC was analyzed from a dynamic perspective by characterizing the occupancy, lifetime, and transition profiles of recurrent FC patterns. Recurrent FC patterns were defined by clustering the BOLD phase-locking patterns obtained using leading eigenvector dynamics analysis (LEiDA). NBS analysis revealed a brain subsystem exhibiting significantly lower within-subsystem correlation values in more depressed participants (high MDI). This subsystem predominantly comprised connections between regions of the default mode network (i.e., precuneus) and regions outside this network. On the other hand, LEiDA results showed that high MDI participants engaged more in a state connecting regions of the default mode, memory retrieval, and frontoparietal network (p-FDR = 0.012); and less in a state connecting mostly the visual and dorsal attention systems (p-FDR = 0.004). Although both our analyses on static and dynamic FC implicate the role of the precuneus in depressive symptoms, only including the temporal evolution of BOLD FC helped to disentangle over time the distinct configurations in which this region plays a role. This finding further indicates that a holistic understanding of brain function can only be gleaned if the temporal dynamics of FC is included.

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“…A resting-state fMRI study 61 found increased neuronal synchronization in the right precuneus, left superior frontal gyrus, and right paracentral lobule, indicating that these areas might play an important role in the pathophysiology of BD. In terms of MDD, lower activity in the right precuneus was observed relative to the HCs 62,63 . Zhu et al 23 found decreased connectivity of the precuneus to the DMN in patients with MDD compared to HCs.…”

Section: Discussionmentioning

confidence: 88%

Alteration of Cortical Functional Networks in Default-Mode Network-Related Regions in Mood Disorders with Resting-State Electroencephalography

Kim¹,

Baek²,

Shim³

et al. 2020

Preprint

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Studies comparing bipolar disorder (BD) and major depressive disorder (MDD) are scarce, and the neuropathology of these disorders is poorly understood. This study investigated source-level cortical functional networks using resting-state electroencephalography (EEG) in patients with BD and MDD. EEG was recorded in 35 patients with BD, 39 patients with MDD, and 42 healthy controls (HCs). Graph theory-based source-level weighted functional networks were assessed via strength, clustering coefficient (CC), and path length (PL) in six frequency bands. At the global level, patients with BD and MDD showed higher strength and CC, and lower PL in the high beta band, compared to HCs. At the nodal level, compared to HCs, patients with BD showed higher high beta band nodal CCs in the right precuneus, left isthmus cingulate, bilateral paracentral, and left superior frontal, belonging to the default-mode network (DMN); however, patients with MDD showed higher nodal CC only in the right precuneus compared to HCs. Although both MDD and BD patients had similar global level network changes, they had different nodal level network changes in DMN-related regions. Our findings might suggest more altered network in the DMN-related regions in patients with BD than in those with MDD.

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Resting-state functional changes in the precuneus within first-episode drug-naive patients with MDD

Cited by 42 publications

References 28 publications

Alterations of Regional Homogeneity and Functional Connectivity Following Short-Term Mindfulness Meditation in Healthy Volunteers

Alterations of Regional Homogeneity and Functional Connectivity Following Short-Term Mindfulness Meditation in Healthy Volunteers

The Dynamics of Functional Brain Networks Associated With Depressive Symptoms in a Nonclinical Sample

Alteration of Cortical Functional Networks in Default-Mode Network-Related Regions in Mood Disorders with Resting-State Electroencephalography

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