Resting-state functional connectivity in individuals with bipolar disorder during clinical remission: a systematic review

Syan, Sabrina K.; Smith, Mara; Frey, Benício N.; Remtulla, Raheem; Kapczinski, Flávio; Hall, Geoffrey B.; Minuzzi, Luciano

doi:10.1503/jpn.170175

Cited by 121 publications

(88 citation statements)

References 73 publications

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“…However, the results for schizophrenia vary in terms of the direction of the effect, and some do not show any differences between patients and controls (e.g., Fox et al, 2017;Wolf et al, 2011), consistent with our current findings. For bipolar disorder, the lack of DMN functional connectivity differences from healthy controls is consistent with other studies that showed no differences, particularly during clinical remission (e.g., Syan et al, 2018).…”

Section: Discussionsupporting

confidence: 90%

“…This was contrary to our hypothesis and previous findings of DMN abnormalities in both clinical samples (e.g., Das et al, 2014;Karbasforoushan & Woodward, 2012). For bipolar disorder, the lack of DMN functional connectivity differences from healthy controls is consistent with other studies that showed no differences, particularly during clinical remission (e.g., Syan et al, 2018). For bipolar disorder, the lack of DMN functional connectivity differences from healthy controls is consistent with other studies that showed no differences, particularly during clinical remission (e.g., Syan et al, 2018).…”

Section: Discussionsupporting

confidence: 88%

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Linking resting‐state networks and social cognition in schizophrenia and bipolar disorder

Jimenez

Riedel

Lee

et al. 2019

Human Brain Mapping

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Individuals with schizophrenia and bipolar disorder show alterations in functional neural connectivity during rest. However, resting‐state network (RSN) disruptions have not been systematically compared between the two disorders. Further, the impact of RSN disruptions on social cognition, a key determinant of functional outcome, has not been studied. Forty‐eight individuals with schizophrenia, 46 with bipolar disorder, and 48 healthy controls completed resting‐state functional magnetic resonance imaging. An atlas‐based approach was used to examine functional connectivity within nine RSNs across the cortex. RSN connectivity was assessed via nonparametric permutation testing, and associations with performance on emotion perception, mentalizing, and emotion management tasks were examined. Group differences were observed in the medial and lateral visual networks and the sensorimotor network. Individuals with schizophrenia demonstrated reduced connectivity relative to healthy controls in all three networks. Individuals with bipolar disorder demonstrated reduced connectivity relative to controls in the medial visual network and connectivity within this network was significantly positively correlated with emotion management. In healthy controls, connectivity within the medial and lateral visual networks positively correlated with mentalizing. No significant correlations were found for either visual network in schizophrenia. Results highlight the role of altered early visual processing in social cognitive deficits in both schizophrenia and bipolar disorder. However, individuals with bipolar disorder appear to compensate for disrupted visual network connectivity on social cognitive tasks, whereas those with schizophrenia do not. The current study adds clarity on the neurophysiology underlying social cognitive deficits that result in impaired functioning in serious mental illness.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 88%

Linking resting‐state networks and social cognition in schizophrenia and bipolar disorder

Jimenez

Riedel

Lee

et al. 2019

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…Attention has been focused on neural connectivity in brain regions called the ‘default mode network,’ including the medial prefrontal cortex, posterior cingulate, precuneus, and other regions. According to a systematic review of resting‐state functional connectivity MRI studies in BD, there are no distinctive differences in the functional connectivity of the default mode network between BD patients and controls. However, seed‐based analysis on regions of interest – such as the amygdala, ventrolateral prefrontal cortex, cingulate gyrus, and medial prefrontal cortex – showed functional connectivity abnormalities.…”

Section: Neuroimaging and Electroencephalographymentioning

confidence: 99%

Current understanding of bipolar disorder: Toward integration of biological basis and treatment strategies

Kato

2019

Psychiatry Clin Neurosci

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Biological studies of bipolar disorder initially focused on the mechanism of action for antidepressants and antipsychotic drugs, and the roles of monoamines (e.g., serotonin, dopamine) have been extensively studied. Thereafter, based on the mechanism of action of lithium, intracellular signal transduction systems, including inositol metabolism and intracellular calcium signaling, have drawn attention. Involvement of intracellular calcium signaling has been supported by genetics and cellular studies. Elucidation of the neural circuits affected by calcium signaling abnormalities is critical, and our previous study suggested a role of the paraventricular thalamic nucleus. The genetic vulnerability of mitochondria causes calcium dysregulation and results in the hyperexcitability of serotonergic neurons, which are suggested to be susceptible to oxidative stress. Efficacy of anticonvulsants, animal studies of candidate genes, and studies using induced pluripotent stem cell‐derived neurons have suggested a relation between bipolar disorder and the hyperexcitability of neurons. Recent genetic findings suggest the roles of polyunsaturated acids. At the systems level, social rhythm therapy targets circadian rhythm abnormalities, and cognitive behavioral therapy may target emotion/cognition (E/C) imbalance. In the future, pharmacological and psychosocial treatments may be combined and optimized based on the biological basis of each patient, which will realize individualized treatment.

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“…A growing number of studies has revealed alterations of the functional brain activity of those systems in BD 6 . However, only few studies to date investigated functional brain activity of BD at rest, showing mixed findings influenced by medication, condition phase and analysis pipeline 7‐10 . Specifically, it has been shown that the resting‐state networks and brain regions most affected in BD are the ACC, PFC, amygdala and insula 9‐11 with specific alterations in the default‐mode network (DMN), salience network (SN), central executive network (CEN) and in the fronto‐parietal network (FPN).…”

Section: Introductionmentioning

confidence: 99%

Resting state networks activity in euthymic bipolar disorder

et al. 2020

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Objectives Bipolar disorder (BD) is a psychiatric condition causing shifts in mood, energy and activity levels severely altering the quality of life of the patients even in the euthymic phase. Although widely accepted, the neurobiological bases of the disorder in the euthymic phase remain elusive. This study aims at characterizing resting state functional activity of the BD euthymic phase in order to better understand the pathogenesis of the disease and build future neurobiological models. Methods Fifteen euthymic BD patients (10 females; mean age 40.2; standard deviation 13.5; range 20–61) and 27 healthy controls (HC) (21 females; mean age 37; standard deviation 10.6; range 22–60) underwent a 3T functional MRI scan at rest. Resting state activity was extracted through independent component analysis (ICA) run with automatic dimensionality estimation. Results ICA identified 22 resting state networks (RSNs). Within‐network analysis revealed decreased connectivity in the visual, temporal, motor and cerebellar RSNs of BD patients vs HC. Between‐network analysis showed increased connectivity between motor area and the default mode network (DMN) partially overlapping with the fronto‐parietal network (FPN) in BD patients. Conclusion Within‐network analysis confirmed existing evidence of altered cerebellar, temporal, motor and visual networks in BD. Increased connectivity between the DMN and the motor area network suggests the presence of alterations of the fronto‐parietal regions, precuneus and cingulate cortex in the euthymic condition. These findings indicate that specific connectivity alterations might persist even in the euthymic state suggesting the importance of examining both within and between‐network connectivity to achieve a global understanding of the BD euthymic condition.

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Resting-state functional connectivity in individuals with bipolar disorder during clinical remission: a systematic review

Cited by 121 publications

References 73 publications

Linking resting‐state networks and social cognition in schizophrenia and bipolar disorder

Linking resting‐state networks and social cognition in schizophrenia and bipolar disorder

Current understanding of bipolar disorder: Toward integration of biological basis and treatment strategies

Resting state networks activity in euthymic bipolar disorder

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