Resting state functional connectivity patterns associated with pharmacological treatment resistance in temporal lobe epilepsy

Pressl, Christina; Brandner, Philip; Schaffelhofer, Stefan; Blackmon, Karen; Dugan, Patricia; Holmes, Manisha; Thesen, Thomas; Kuzniecky, Ruben; Devinsky, Orrin; Freiwald, Winrich A.

doi:10.1016/j.eplepsyres.2018.11.002

Cited by 30 publications

(26 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are emerging research studies to introduce the alterations of brain network in epilepsy into clinical practice, such as seizure localization [20,21], surgical outcome prediction [22], neuropsychological implications [6,23], and association with medical outcomes [9,10,24]. There are several reports in line with our present study.…”

Section: Discussionsupporting

confidence: 85%

“…They found that patients with drug-resistant epilepsy (DRE) had more widespread gray matter atrophy compared with patients with drug-controlled epilepsy (DCE). A recent study using rs-fMRI demonstrated that healthy controls and patients with DCE showed similar functional connectivity patterns, whereas patients with DRE exhibited a significant bilateral decrease in thalamohippocampal functional connectivity [9]. Another study using rs-fMRI also showed significance for longer paths and reduced local efficiency within the default mode network of patients with DCE compared with those with DRE [10].…”

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Intrinsic hippocampal and thalamic networks in temporal lobe epilepsy with hippocampal sclerosis according to drug response

Lee

Park

2020

Seizure

View full text Add to dashboard Cite

The aim of this study was to investigate whether intrinsic hippocampal or thalamic networks in patients with temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS) were different according to antiepileptic drug (AED) response. Methods: We enrolled 80 patients with TLE with HS and 40 healthy controls. Of the patients with TLE with HS, 43 were classified as a drug-resistant epilepsy (DRE) group, whereas 37 patients were enrolled as a drug-controlled epilepsy (DCE) group. We investigated the structural connectivity of the global brain, intrinsic hippocampal, and intrinsic thalamic networks based on structural volumes in the patients with DRE and DCE, and analyzed the differences between them. Results: There were significant alterations of the intrinsic hippocampal network compared with healthy controls. The average degree and the global efficiency were decreased, whereas the characteristic path length was increased in the patients with DRE compared with those in healthy controls. In the patients with DCE, only the small-worldness index was decreased compared with healthy controls. Compared to the patients with DCE, the mean clustering coefficient was increased in the patients with DRE. Conclusion:We found that the intrinsic hippocampal network in patients with TLE with HS was different according to AED response. The patients with DRE had more severe disruptions of the intrinsic hippocampal network than those with DCE compared with healthy controls. These findings suggested that the hippocampal network might be related to AED response and could be a new biomarker of medical outcome in patients with TLE with HS.

show abstract

Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 97%

Intrinsic hippocampal and thalamic networks in temporal lobe epilepsy with hippocampal sclerosis according to drug response

Lee

Park

2020

Seizure

View full text Add to dashboard Cite

show abstract

“…Further, diverse changes in neural network connectivity have also been described in response to various treatments in focal epilepsy. Studies have identified regions showing altered connectivity between patients with well-controlled epilepsy and those with treatment-resistant epilepsy (20,21). In this study, all included patients were medically refractory.…”

Section: Discussionmentioning

confidence: 99%

Regional and remote connectivity patterns in focal extratemporal lobe epilepsy

Liu¹,

Yue²,

Gong³

et al. 2021

Ann Transl Med

View full text Add to dashboard Cite

Background: Focal epilepsy accounts for most epilepsy cases, and frontal lobe epilepsy (FLE) accounts for the largest proportion of cases of extratemporal epilepsy syndrome. The epileptogenic zone is usually not easy to locate, contributing to a lack of imaging studies. The objective of this study was to evaluate functional connectivity patterns to explore the underlying pathological mechanisms of this disorder.Methods: Forty-three patients with focal extratemporal epilepsy [mean age ± standard deviation (SD): 29.51±8.04 years, 19 males] and the same number of healthy controls (mean age ± SD: 29.56±8.02 years, 19 males) were recruited to undergo functional magnetic resonance imaging. Mean regional homogeneity (ReHo) was measured, and regions showing significant alterations in ReHo in patients were identified to examine functional connectivity (FC). In particular, FC within the default mode network (DMN) in patients was analyzed.Results: Patients with extratemporal lobe epilepsy showed significantly higher ReHo in the bilateral precentral gyrus, and lower ReHo in frontal-cerebellum regions than healthy controls [P<0.05, Gaussian random field (GRF)-corrected]. FC analysis based on regions of interest showed significantly higher connectivity in the frontoparietal-insula region and lowered FC in the frontal-cerebellum regions (P<0.05, GRF-corrected). Altered FC within DMN was also demonstrated (P<0.05, GRF-corrected).Conclusions: Analyses of ReHo and FC based on regions of interest suggest epilepsy-related neural networks are located mainly in frontal regions in extratemporal lobe epilepsy. These findings reveal disruptions of interactions and connectivity of large-scale neural networks and frontotemporal-cerebellar regions, suggesting connectivity-based pathophysiology.

show abstract

“…Previous studies have shown that connectivity to the contralateral TL is associated with seizure outcome 32 . Several studies have also shown that subcortical connectivity, namely thalamocortical connectivity, could predict seizure outcome in TL epilepsy 20,33 . One challenge to these studies is that the collinearity between TL+ epilepsy and seizure outcome was not considered.…”

Section: Discussionmentioning

confidence: 99%

Temporal‐plus epilepsy in children: A connectomic analysis in magnetoencephalography

et al. 2020

View full text Add to dashboard Cite

Objective: Seizure recurrence following surgery for temporal lobe (TL) epilepsy may be related to extratemporal epileptogenic foci, so-called temporal-plus (TL+) epilepsy. Here, we sought to leverage whole brain connectomic profiling in magnetoencephalography (MEG) to identify neural networks indicative of TL+ epilepsy in children. Methods: Clinical and MEG data were analyzed for 121 children with TL and TL+ epilepsy spanning 20 years at the Hospital for Sick Children. Resting-state connectomes were derived using the weighted phase lag index from neuromagnetic oscillations. Multidimensional associations between patient connectomes, TL versus TL+ epilepsy, seizure freedom, and clinical covariates were performed using a partial least squares (PLS) analysis. Bootstrap resampling statistics were performed to assess statistical significance. Results: A single significant latent variable representing 66% of the variance in the data was identified with significant contributions from extent of epilepsy (TL vs TL+), duration of illness, and underlying etiology. This component was associated with significant bitemporal and frontotemporal connectivity in the theta, alpha, and beta bands. By extracting a brain score, representative of the observed connectivity profile, patients with TL epilepsy were dissociated from those with TL+, independent of their postoperative seizure outcome. Significance: By analyzing 121 connectomes derived from MEG data using a PLS approach, we find that connectomic profiling could dissociate TL from TL+ epilepsy. These findings may inform patient selection for resective procedures and guide decisions surrounding invasive monitoring.

show abstract

Resting state functional connectivity patterns associated with pharmacological treatment resistance in temporal lobe epilepsy

Cited by 30 publications

References 38 publications

Intrinsic hippocampal and thalamic networks in temporal lobe epilepsy with hippocampal sclerosis according to drug response

Intrinsic hippocampal and thalamic networks in temporal lobe epilepsy with hippocampal sclerosis according to drug response

Regional and remote connectivity patterns in focal extratemporal lobe epilepsy

Temporal‐plus epilepsy in children: A connectomic analysis in magnetoencephalography

Contact Info

Product

Resources

About