Resting-state functional connectivity remains unaffected by preceding exposure to aversive visual stimuli

Geissmann, Léonie; Gschwind, Leo; Schicktanz, Nathalie; Deuring, Gunnar; Rosburg, Timm; Schwegler, Kyrill; Gerhards, Christiane; Milnik, Annette; Pflueger, Marlon O.; Mager, Ralph; Quervain, Dominique J.‐F. de; Coynel, David

doi:10.1016/j.neuroimage.2017.11.046

Cited by 9 publications

(7 citation statements)

References 88 publications

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“…Before turning to the novel aspects of the present study, we first sought to root our individual differences analyses in a replication of past work of group-level amygdala RSFC patterns (Geissmann et al, 2018). First, pre-encoding resting-state networks resembled those previously reported (Roy et al, 2009;Geissmann et al, 2018), with positive RSFC of the bilateral amygdala with large swaths of ventromedial and dorsomedial prefrontal cortex (PFC), temporal lobes, orbital and inferior PFC (Fig.…”

Section: Resting-state Fmri Resultsmentioning

confidence: 70%

“…We first examined group-level pre-encoding (Z Pre ) amygdala RSFC maps as a comparison to prior work characterizing RSFC networks of the amygdala. For comparison with previous work reporting few changes in the amygdala RSFC following emotion picture viewing (Geissmann et al, 2018), next we examined overall pre-to postencoding increases in amygdala RSFC (Z Post Ͼ Z Pre masked with Z Post thresholded at p Ͻ 0.005). These first two analyses were used to establish our group findings before exploring the novel inter-individual difference questions central to the purpose of the current study.…”

Section: Resting-state Fmri Analysesmentioning

confidence: 99%

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Post-Encoding Amygdala-Visuosensory Coupling Is Associated with Negative Memory Bias in Healthy Young Adults

Kark

Kensinger

2019

J. Neurosci.

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The amygdala is well documented as the critical nexus of emotionally enhanced memory, yet its role in the creation of negative memory biases, better memory for negative compared with positive stimuli, has not been clarified. Although prior work suggests valence-specific effects at the moment of "online" encoding and retrieval, with enhanced visuosensory processes supporting negative memories in particular, here we tested the novel hypothesis that the amygdala engages with distant cortical regions after encoding in a manner that predicts inter-individual differences in negative memory biases in humans. Twenty-nine young adults (males and females) were scanned while they incidentally encoded negative, neutral, and positive scenes, each preceded by a line-drawing sketch of the scene. Twenty-four hours later, participants were scanned during an Old/New recognition memory task with only the line-drawings presented as retrieval cues. We replicated and extended our prior work, showing that enhanced online visuosensory recapitulation supports negative memory. Critically, resting-state scans flanked the encoding task, allowing us to show for the first time that individual differences in "off-line" increases in amygdala resting-state functional connectivity (RSFC) immediately following encoding relate to negative and positive memory bias at test. Specifically, post-encoding increases in amygdala RSFC with visuosensory and frontal regions were associated with the degree of negative and positive memory bias, respectively. These findings provide new evidence that valence-specific negative memory biases can be linked to the way that sensory processes are integrated into amygdala-centered emotional memory networks. for assistance with participant recruitment and data collection and processing; Ehri Rhyu for helpful discussions of the mediation analysis; and Jaclyn Ford for her thoughtful comments and helpful discussions of this work. Further details of the recapitulation replication results and exploratory moderated mediation analysis can be obtained by contacting the corresponding author directly. This work was included in the dissertation of S.M.K.Decades of research has placed the amygdala at the center of the emotional memory network. Despite the clinical importance of disproportionate memory for negative compared with positive events, it is not known whether post-encoding increases in amygdala-cortical coupling, possibly reflective of early consolidation processes, bear any influence on the degree or direction of such emotional memory biases. We demonstrate that, across participants, increases in post-encoding amygdala coupling with visuosensory and frontal regions are associated with more pronounced negative and positive memory biases, respectively. These findings provide the first evidence linking post-encoding amygdala modulation to the degree of negative or positive memory bias, emphasizing the need for valence-based accounts of the amygdala's role in emotional memory.

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Section: Resting-state Fmri Resultsmentioning

confidence: 70%

Section: Resting-state Fmri Analysesmentioning

confidence: 99%

Post-Encoding Amygdala-Visuosensory Coupling Is Associated with Negative Memory Bias in Healthy Young Adults

Kark

Kensinger

2019

J. Neurosci.

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“…Omission of NR in the derivation of FC maps from dual regression can prevent a potential source of error whose impact cannot be gauged precisely without knowledge of the exact spatial distributions of signals within the fMRI data. Rather than include all spatial maps from group ICA as spatial priors (Abram et al, ; Filippini et al, ; Geissmann et al, ; Muetzel et al, ; Pannekoek et al, ; Rueter, Abram, MacDonald, Rustichini, & DeYoung, ; Smith et al, ), some dual regression studies omit spatial priors thought to represent noise (Baggio et al, ; Fan et al, ; Giorgio, Zhang, Costantino, De Stefano, & Frezzotti, ; Ishaque et al, ; Klaassens et al, ; Schumacher et al, ); however, the remaining “nuisance” spatial maps may still reduce FC map accuracy, through mechanisms described in this article: Appendix A shows an example where DRA quality scores did not improve after omitting only spatial priors thought to represent structured noise. Reduction of NR to a small number that are highly consistent in spatial distributions across all subjects/sessions might avoid these pitfalls, provided that denoising procedures do not remove the signal corresponding to these NR from the fMRI data.…”

Section: Discussionmentioning

confidence: 99%

“…Our linear regression procedures are based on the equation

boldY = b_{1} X_{1} + b_{2} X_{2} + b_{3} X_{3} + \dots + b_{n} X_{n} + normalc + boldε,

where the best approximation for the values of vector Y (the dependent variable, representing the spatial map for a given time point or the vector time course for a given voxel) for a given set of vectors { X 1 , X 2 , … X n } (n independent variables, representing either spatial maps or time courses) is found by choosing the set of regression coefficients {b 1 , b 2 , … b n } that minimize the sum of squares of the residual values in vector ε . We say that the independent variables are being regressed onto the dependent variable, borrowing terminology from Huettel et al (), recognizing that no consensus for such terminology yet exists in the dual regression literature (Abram et al, ; Baggio et al, ; Chahine, Richter, Wolter, Goya‐Maldonado, & Gruber, ; Geissmann et al, ; Ishaque et al, ; Muetzel et al, ; Odish et al, ; Pannekoek et al, ; Smith et al, ). Our dependent and independent variables are always mean centered prior to regression (making the terms orthogonal and uncorrelated synonymous); and to ensure that mean values for independent variables predict the mean value for the dependent variable, c is set to zero.…”

Section: Theorymentioning

confidence: 99%

Omission of temporal nuisance regressors from dual regression can improve accuracy of fMRI functional connectivity maps

Kelly

Hoptman

Alexopoulos

et al. 2019

Human Brain Mapping

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Functional connectivity (FC) maps from brain fMRI data can be derived with dual regression, a proposed alternative to traditional seed‐based FC (SFC) methods that detect temporal correlation between a predefined region (seed) and other regions in the brain. As with SFC, incorporating nuisance regressors (NR) into the dual regression must be done carefully, to prevent potential bias and insensitivity of FC estimates. Here, we explore the potentially untoward effects on dual regression that may occur when NR correlate highly with the signal of interest, using both synthetic and real fMRI data to elucidate mechanisms responsible for loss of accuracy in FC maps. Our tests suggest significantly improved accuracy in FC maps derived with dual regression when highly correlated temporal NR were omitted. Single‐map dual regression, a simplified form of dual regression that uses neither spatial nor temporal NR, offers a viable alternative whose FC maps may be more easily interpreted, and in some cases be more accurate than those derived with standard dual regression.

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“…A exibição de stímulos visuais estáticos é um método amplamente empregado para induzir a emoção de alegria e medo em condições experimentais (Geissmann et al, 2018). Em boa parte dos estudos, os estímulos visuais capazes de induzir estas emoções são retirados da International Affective Picture Systema (IAPS - Lang et al, 2008) ou de bases de dado validadas contendo faces humanas expressando alegria (Ebner et al, 2010).…”

Section: Estímulos Visuais Estáticosunclassified

Efeito da indução de emoções sobre a atenção visual em propagandas de cerveja: um estudo de neurociência aplicada ao marketing

Paula¹

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Evidence shows that traditional marketing campaigns are becoming less effective. Given this, a series of initiatives have been undertaken with the objective of increasing the efficiency of advertising and ensuring the strengthening of brands before their potential consumers. The search for objective measures of consumer behavior has led in recent years to a growing effort to employ neuroscience concepts and methods in marketing, with the aim of favoring the improvement of advertising, since neuroscience concepts and methods can measure objective variables until then captured only through subjective reports. Emotions have long been known to have an important effect on consumer behavior, and consumers have affective relationships with their brands and products. However, it has been found that so far no study has investigated whether the induction of incidental emotions could have any effect on the level of visual attention in advertising, and this was precisely the purpose of this thesis. Three independent groups were constituted, with 20 individuals each. Each group was induced to neutral, joy and fear and then the level of visual attention was observed through, eye tracking equipment, in ten beer advertising stimuli. The results revealed that induction of joy increased visual attention to brand, products and human faces within advertisements, while induction of fear produced the opposite effect. The implications of these findings for advertising strategies are discussed.

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Resting-state functional connectivity remains unaffected by preceding exposure to aversive visual stimuli

Cited by 9 publications

References 88 publications

Post-Encoding Amygdala-Visuosensory Coupling Is Associated with Negative Memory Bias in Healthy Young Adults

Post-Encoding Amygdala-Visuosensory Coupling Is Associated with Negative Memory Bias in Healthy Young Adults

Omission of temporal nuisance regressors from dual regression can improve accuracy of fMRI functional connectivity maps

Efeito da indução de emoções sobre a atenção visual em propagandas de cerveja: um estudo de neurociência aplicada ao marketing

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