Resting-State Functional Magnetic Resonance Imaging and Functional Connectivity Density Mapping in Patients With Optic Neuritis

Song, Ke; Wang, Yong; Ren, Mei-Xia; Li, Jiao; Su, Ting; Chen, Si-Yi; Shao, Yi; Lv, Ya-Li

doi:10.3389/fnins.2021.718973

Cited by 3 publications

(1 citation statement)

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“…Moreover, recent studies demonstrated regulatory and functional aspects of the kynurenine pathway, which has been shown to possess neuroprotective and antidepressant-like properties [ 37 , 38 ]. In addition, there is evidence [ 39 , 40 ] that diet may also protect from depressive disorders and improve mental health through mechanisms that are related to inflammation, endogenous metabolic factors in cognitive and emotional functions, and pathological neural substrates of depressive disorder, especially on frontal lobe dysfunction [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Possible Association of Nucleobindin-1 Protein with Depressive Disorder in Patients with HIV Infection

et al. 2022

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Background: Mental disorders linked with dysfunction in the temporal cortex, such as anxiety and depression, can increase the morbidity and mortality of people living with HIV (PLWHA). Expressions of both nucleobindin 1 (NUCB1) and cannabinoid receptor 1 (CNR1) in the neurons have been found to alter in patients with depressive disorder, but whether it is involved in the development of depression in the context of HIV infection is unknown. Objectives To investigate the effects of NUCB1 on depressive disorder among PLWHA and preliminarily explore the underlying molecular mechanisms. Methods: Individuals who were newly HIV diagnosed were assessed on the Hospital Anxiety and Depression scale (HADS). Then SHIV-infected rhesus monkeys were used to investigate the possible involvement of the NUCB1 and the CNR1 protein in depression-like behavior. Results: The prevalence rate of depression among PLWHA was 27.33% (41/150). The mechanism results showing elevated NUCB1 levels in cerebrospinal fluid from HIV-infected patients suffering from depression were confirmed compared to those of HIV-infected patients. Moreover, the immunohistochemical analysis indicated the expression of NUCB1 in the temporal cortex neurons of SHIV-infected monkeys was higher than that of the healthy control. Conversely, CNR1 expression was down-regulated at protein levels. Conclusions: Depression symptoms are common among PLWHA and associate with NUCB1 expression increases, and NUCB1 may be a potential target for depression.

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