Resting state glucose utilization and the CERAD cognitive battery in patients with Alzheimer's disease

Teipel, Stefan J.; Willoch, Frode; Ishii, Kazunari; Bürger, Katharina; Drzezga, Alexander; Engel, Rolf R.; Bartenstein, Peter; Möller, H.-J.; Schwaiger, Markus; Hampel, Harald

doi:10.1016/j.neurobiolaging.2005.03.015

Cited by 79 publications

(62 citation statements)

References 67 publications

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“…However, the CERAD-NAB covers a wide spectrum of cognitive impairment and the effects of misclassification of severity of cognitive impairment would be equally distributed across the sample, if at all present. The CERAD-NAB total score has been previously applied to control for cognitive dysfunction in a similar study on the same patient group (Perneczky et al, 2007), and Teipel and co-workers reported that CERAD-NAB subtests were significantly correlated with rCMRglc in the frontal cortex (Teipel et al, 2006). Furthermore, the CERAD-NAB was also associated with rCMRglc in brain regions affected by nonfluent progressive aphasia (Perneczky et al, 2007).…”

Section: Discussionmentioning

confidence: 98%

Male gender is associated with greater cerebral hypometabolism in frontotemporal dementia: evidence for sex‐related cognitive reserve

Perneczky

Diehl‐Schmid

Förstl

et al. 2007

Int J Geriat Psychiatry

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Section: Discussionmentioning

confidence: 98%

Male gender is associated with greater cerebral hypometabolism in frontotemporal dementia: evidence for sex‐related cognitive reserve

Perneczky

Diehl‐Schmid

Förstl

et al. 2007

Int J Geriat Psychiatry

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“…Only few studies have attempted to define the linkage between language impairment and cortical atrophy in AD (van der Flier, van den Heuvel, Weverling-Rijnsburger, Bollen, Westendorp, van Buchem, & Middelkoop, 2002;Pantel, Schonknecht, Essig, & Schroder, 2004;Teipel, Willoch, Ishii, Burger, Drzezga, Engel, Bartenstein, Moller, Schwaiger, & Hampel, 2006). …”

Section: Discussionmentioning

confidence: 99%

“…While investigating the relationship between the CERAD language tests and FDG-PET metabolism in AD Teipel et al found the animal fluency test to be associated with left temporo-parietal and left prefrontal metabolism, while the abbreviated 15-item Boston Naming Test (BNT) version linked to left middle temporal, left superior parietal and fusiform metabolism. (Teipel, Willoch, Ishii, Burger, Drzezga, Engel, Bartenstein, Moller, Schwaiger, & Hampel, 2006) Impaired verbal and nonverbal semantic performance correlated with hypometabolism in the left anterior temporal (Brodmann areas, BA 21 and 38), posterior inferior temporal (BA 37), inferior parietal (supramarginal gyrus, BA 40) and medial occipital cortex (Zahn, Juengling, Bubrowski, Jost, Dykierek, Talazko, & Huell, 2004). Another FDG-PET study by Hirono et al described correlations between animal fluency and the left superior and inferior frontal, bilateral anterior cingulate and left inferior temporal metabolism, and naming performance was found to correlate with left middle and inferior temporal metabolism (Hirono, Mori, Ishii, Imamura, Tanimukai, Kazui, Hashimoto, Takatsuki, Kitagaki, & Sasaki, 2001).…”

Section: Introductionmentioning

confidence: 99%

3D mapping of language networks in clinical and pre-clinical Alzheimer’s disease

Apostolova

Rogers

et al. 2008

Brain and Language

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We investigated the associations between Boston Naming and the animal fluency tests and cortical atrophy in 19 probable AD and 5 multiple domain amnestic mild cognitive impairment patients who later converted to AD. We applied a surface-based computational anatomy technique to MRI scans of the brain and then used linear regression models to detect associations between animal fluency and Boston naming test (BNT) performance and cortical atrophy. The global permutation-corrected significance for the maps associating BNT performance with cortical atrophy was p=0.0124 for the left and p=0.0196 for the right hemisphere and for the animal fluency maps p=0.055 for the left and p=0.073 for the right hemisphere. The degree of language impairment correlated with cortical atrophy in the left temporal and parietal lobes (BA 20, 21, 37, 39, 40, 7), bilateral frontal lobes (BA 8, 9, 44) and the right temporal pole (BA 38). Using a novel 3D mapping technique, we demonstrated that in AD language abilities are strongly influenced by the integrity of the perisylvian cortical regions.

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“…Matsuoka et al [58] reported another representative instance of variability in neurofunctional findings depending on the neuropsychological measure in a large sample of drug-naïve AD patients, in whom overall performance on CDT, the partial score on locating numbers of the clock and the partial score on setting the hands were correlated with atrophy in distinct parietal, posterior temporal and frontal regions. A PET study using copying of simple geometrical figure as a measure of constructional abilities showed, instead, an exclusive correlation of copying performance with the left inferior parietal lobule and the left inferior frontal gyrus [121].…”

Section: Mechanisms Giving Rise To Drawing Disorders In Ad Patientsmentioning

confidence: 98%

Drawing Disorders in Alzheimer’s Disease and Other Forms of Dementia

Trojano

Gainotti

2016

JAD

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Abstract. Drawing is a multicomponential process that can be impaired by many kinds of brain lesions. Drawing disorders are very common in Alzheimer's disease and other forms of dementia, and can provide clinical information for the distinction of the different dementing diseases. In our review we started from an overview of the neural and cognitive bases of drawing, and from a recollection of the drawing tasks more frequently used for assessing individuals with dementia. Then, we analyzed drawing disorders in dementia, paying special attention to those observed in Alzheimer's disease, from the prodromal stages of the amnesic mild cognitive impairment to the stages of full-blown dementia, both in the sporadic forms with late onset in the entorhino-hippocampal structures and in those with early onset in the posterior neocortical structures. We reviewed the drawing features that could differentiate Alzheimer's disease from vascular dementia and from the most frequent forms of degenerative dementia, namely frontotemporal dementia and Lewy body disease. Finally, we examined some peculiar aspects of drawing disorders in dementia, such as perseverations, rotations, and closing-in. We argue that a careful analysis of drawing errors helps to differentiate the different forms of dementia more than overall accuracy in drawing.

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Resting state glucose utilization and the CERAD cognitive battery in patients with Alzheimer's disease

Cited by 79 publications

References 67 publications

Male gender is associated with greater cerebral hypometabolism in frontotemporal dementia: evidence for sex‐related cognitive reserve

Male gender is associated with greater cerebral hypometabolism in frontotemporal dementia: evidence for sex‐related cognitive reserve

3D mapping of language networks in clinical and pre-clinical Alzheimer’s disease

Drawing Disorders in Alzheimer’s Disease and Other Forms of Dementia

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