Resting-state networks and dissociation in psychogenic non-epileptic seizures

Cortical thickness, surface area and folding in patients with psychogenic nonepileptic seizures

“…In fact, loss of consciousness is the common feature in different clinical expressions of PNES, in addition to abnormal coping styles, and lack of motor control (van der Krujis et al, 2012). Hence, through structural MRI data our results support observations and conclusions coming out of the previous functional connectivity study (van der Kruijs et al, 2014).…”

“…Namely, van der Kruijs et al (2014) have shown that PNES patients have an increased coactivation of several regions in the resting-state networks associated with fronto-parietal activation (orbito-frontal, insular and subcallosal region), executive control (cingulate and insular cortex), sensorimotor functioning (cingulate gyrus, superior parietal lobe, pre-and postcentral gyri, and suplementar motor area), and the default mode (precuneus, and (para-) cingulate region).…”

White matter diffusion abnormalities in patients with psychogenic non-epileptic seizures

“…One study already found abnormally strong functional connectivity between regions involved in movement (precentral sulcus), executive control (inferior frontal gyrus) and emotion (insula) suggesting that abnormal emotion processing can affect executive control and can be linked to abnormal expression of motor function such as seizure-like episodes (van der Kruijs et al, 2012). These authors also reported abnormalities in resting-state networks that provide neural correlates for an underlying process of dissociation (van der Kruijs et al, 2014).…”

Functional neurological disorders: mechanisms and treatment

“…Resting state fMRI and FDG-PET studies in non-epileptic attacks found stronger connectivity between the precentral sulcus, intraparietal sulcus, insula, and supramarginal gyrus [60], more general frontal-parietal changes [61] and hypometabolism in right inferior parietal and anterior cingulate regions compared to controls (Fig. 3) [62].…”