Resting‐state theta‐phase gamma amplitude coupling as a biomarker for the transdiagnostic dimensional approach in psychiatric disorders

Kim, Minah; Shim, Yurim; Kwon, Jun-Beom; Bae, Sujin; Lee, Junhee; Cha, Jiook; Choi, Soo-Hee; Kim, Se Hyun; Kang, Ung Gu; Kwon, Jun Soo

doi:10.1111/pcn.13554

Cited by 1 publication

(2 citation statements)

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“…OCS are less formal than OCD for classifying the abnormal state, thus this classification may have led to overestimates of the strength of the association. A transdiagnostic approach, which focuses on common symptoms and processes across different diagnostic categories, has recently emerged and takes into account the complexity and multi-faceted nature of mental health problems [ 35 ]. By targeting the underlying mechanisms that contribute to the development and persistence of OCS, a transdiagnostic approach has the potential to lead to more effective and efficient treatment and management strategies.…”

Section: Discussionmentioning

confidence: 99%

“…A transdiagnostic approach, which focuses on common symptoms and processes across different diagnostic categories, has recently emerged and takes into account the complexity and multi-faceted nature of mental health problems. 35 By targeting the underlying mechanisms that contribute to the development and persistence of OCS, a transdiagnostic approach has the potential to lead to more effective and efficient treatment and management strategies. For example, cognitive-behavioral therapy is often used to treat OCS by focusing on changing negative thought patterns and behaviors.…”

Section: Discussionmentioning

confidence: 99%

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Effect Modification of Cortisol on the Associations Between Obsessive-Compulsive Symptoms on Suicidality in Patients With Acute Coronary Syndrome

Park

Kim

Kang

et al. 2023

Psychiatry Investig

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Objective Obsessive-compulsive symptoms (OCS) and suicidal ideation (SI) are common in patients with acute coronary syndrome (ACS). This study investigated the associations of OCS and serum cortisol levels with SI, and further evaluated the possible modifying effects of cortisol on the associations between OCS and SI in acute and chronic phases of ACS.Methods In total, 969 ACS patients were recruited from a tertiary university hospital in Korea within 2 weeks of disease onset and evaluated in terms of OCS (using the OCS dimension of the Symptom Checklist-90–Revised), serum cortisol levels, and SI (using the “suicidal thoughts” item of the Montgomery–Åsberg Depression Rating Scale). Covariates included sociodemographics, depression, vascular risk factors, and disease severity. After 1 year, 711 patients were re-evaluated in terms of SI. Logistic regression analysis was performed with adjustment for covariates.Results Higher OCS was significantly associated with SI both at baseline and follow-up. Serum cortisol showed no such association, but modified the association between OCS and SI. That was the associations were significant only in the higher but not in the lower serum cortisol levels, with significant interaction terms after adjusted for relevant covariates.Conclusion Evaluating OCS and serum cortisol levels at the acute phase could improve the accuracy of clinical predictions of SI both in the acute and chronic phases of ACS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%