Restless Leg Syndrome in Diabetics Compared with Normal Controls

Abstract

Introduction. Restless leg syndrome (RLS) is a common sleep disorder which is characterized by urge to move the legs accompanied by disturbing and uncomfortable leg sensation during night and rest. This common condition affects 7–10% of general population and is frequently unrecognized, misdiagnosed, and poorly managed. Several clinical conditions like diabetes have been associated with secondary form of RLS. This study analyzed the frequency and possible risk factor for RLS development in diabetic patient. Material and Methods. This descriptive case-control study was done on 140 consecutive outpatient diabetics and age, sex, and body mass index matched control group. RLS was diagnosed by criteria of the International RLS Study Group. Results. Prevalence of RLS was 28.6% in diabetes and 7.1% in control group (P = 0.001). Sex difference was not significant and with rising duration of diabetes prevalence of RLS was not increased. Discussion. With regarding significant association between RLS and diabetes and its negative impact on quality of life/health outcome/sleep/daytime activity/cognitive function/ and mental state of diabetic patient/higher awareness of RLS among physicians and related health worker suggested.

Restless leg syndrome among Sudanese patients with type 2 diabetes mellitus: A case-control study

“…another theory is the prolonged sleep loss that could lead to insulin resistance and metabolic disturbances [19]. In the present study, restless leg syndrome was found in 31.7% of patients compared to 10.3% of control subjects, the present finding was higher than the result of (Harashima et al [20] (8%), The current findings were similar to a study published by Zobeiri et al [21] who concluded a prevalence of 28.6% compared to 7.1% in control subjects. Previous studies from other countries found lower rates of RLS among patients with diabetes [22,23].…”

Prevalence, severity, and impact on quality of life of restless leg syndrome in patients with liver cirrhosis in India

“…The scores of individual questions are aggregated to yield a total score ranging from 0 to 40. Based on the IRLS score, RLS was graded as mild (0-10), moderate (11)(12)(13)(14)(15)(16)(17)(18)(19)(20), severe (21)(22)(23)(24)(25)(26)(27)(28)(29)(30), and very severe (31-40). All the subjects diagnosed with RLS were provided the standard-of-care management by the neurologist (VP) in the research team [22].…”

“…Large population-based studies have shown that RLS affects up to 5 % to 15 % of individuals [7]. It is commonly observed in persons with peripheral neuropathy [8], and its prevalence is increased in systemic illnesses such as chronic kidney disease (CKD) [9], hypothyroidism [10], diabetes mellitus [11,12], and iron deficiency anemia [13]. Since both RLS [14] and cirrhosis [5,15] are known to be associated with sleep disturbance, one may expect an association between RLS and LC.…”

Ih contributes to increased motoneuron excitability in restless legs syndrome

“…; Lin et al . ), all of which are risk factors for developing RLS (Hellmann & Tschudy, ; Zobeiri & Shokoohi, ; Schlesinger et al . ).…”