Restless Leg Syndrome: Pathophysiology, Diagnostic Criteria, and Treatment

Amir, Adam; Masterson, Ryan M; Halim, Abdul; Nava, Andrew

doi:10.1093/pm/pnab253

Cited by 7 publications

(11 citation statements)

References 15 publications

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“…Shorter sleep duration is associated with sleep disorders. Possible mechanisms may be frequent awakenings and disruption of sleep caused by sleep disorders (e.g., restless leg syndrome, sleep apnea), which could further lead to a short duration of sleep [ 28 , 29 ]. In addition, previous studies have shown that short sleep duration may represent a marker for sleep disorder severity [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

“…In this study, we aimed to derive obesity-related dietary patterns among American adults with PLS and further examined the association between dietary patterns and sleep disorders. Moreover, sleep disorders may reduce sleep duration, as they cause frequent awakenings and disruption of sleep [ 28 , 29 ]. Thus, the association of sleep duration with dietary patterns was examined to support findings for sleep disorders.…”

Section: Introductionmentioning

confidence: 99%

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The Obesity-Related Dietary Pattern Is Associated with Higher Risk of Sleep Disorders: A Cross-Sectional Study from NHANES

et al. 2022

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Evidence on the association between dietary patterns and sleep disorders is limited and controversial. In addition, studies evaluating the effect of dietary patterns on sleep disorders have seldom considered the critical role of obesity. We aimed to explore obesity-related dietary patterns and evaluate their impact on sleep disorders using data from the National Health and Nutrition Examination Survey 2005–2014. In total, 19,892 participants aged over 20 years with two-day dietary recalls were enrolled. Obesity-related dietary patterns explaining most variance in waist circumference and BMI simultaneously were extracted from twenty-six food groups by the using partial least squares method. Sleep disorder and sleep duration, which were defined by self-reported questions, were the primary and the secondary outcome, respectively. Generalized linear models were performed to estimate the association of sleep disorders and sleep duration with dietary patterns. Two types of dietary patterns were identified. The “high fats, refined grains, and meat” pattern was characterized by high intakes of solid fats, cured meat, potatoes, refined grains, meat, cheese, and added sugars. The “low whole grains, vegetables, and fruits” pattern was characterized by low intakes of oils, whole grains, nuts and seeds, milk, fruits, and several vegetables. Participants with the highest adherence to the “high fats, refined grains, and meat” pattern had a higher risk for sleep disorders (OR (95%CI): 1.43 (1.12, 1.84)) and shorter sleep duration (β (95%CI): −0.17 (−0.26, −0.08)) compared to those with the lowest adherence. The corresponding associations for the “low whole grains, vegetables, and fruits” pattern were only significant for sleep duration (β (95%CI): −0.26 (−0.37, −0.15)). Our results found that the dietary pattern characterized by high solid fats, cured meat, potatoes, refined grains, meat, cheese, and added sugars, was associated with a higher risk for sleep disorders and shorter sleep duration.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Obesity-Related Dietary Pattern Is Associated with Higher Risk of Sleep Disorders: A Cross-Sectional Study from NHANES

et al. 2022

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“…However, evidence suggests the role of iron deficiency in the onset and progression of RLS, likely by promoting dysfunction in the dopaminergic and serotoninergic systems in the brain and spinal cord. Additionally, RLS prevalence increases in patients with chronic renal failure, anemia, and pregnancy [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

An Unusual Case of an Acute Episode of Restless Leg Syndrome Following Oral Metoclopramide Therapy

Aljunaid

2024

Cureus

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Restless leg syndrome (RLS) is a chronic disorder characterized by a compulsive urge to move the legs, accompanied by various subjective symptoms and a distinctive nyctimeral pattern. A negligent entity is drug-induced RLS, which may be challenging to recognize by practitioners due to its rarity. Among various drugs that can induce or exacerbate RLS, metoclopramide is notable; however, the literature primarily describes cases related to its intravenous forms. In this case presentation, a 33-year-old male experienced drug-related gastrointestinal (GI) symptoms after starting semaglutide for weight loss. Semaglutide was discontinued, and oral metoclopramide was administered to manage the GI symptoms. Subsequently, he developed RLS-like symptoms, which resolved within 48 hours of stopping metoclopramide. His family history included chronic RLS. Laboratory tests were normal. The case highlights a potential link between drug administration and transient RLS symptoms. This case suggests that RLS can be a rare, reversible side effect of oral metoclopramide. It emphasizes the need for careful monitoring of RLS symptoms in patients using this drug and highlights the variability of side effects depending on the method of drug administration. The case serves as a reminder of the unpredictable nature of drug reactions and the importance of vigilance in pharmacotherapy.

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“…Restless legs syndrome/Willis-Ekbom disease (RLS/WED) is a sensorimotor network disorder with an elusive underlying pathophysiology [1][2][3]. Despite being generally considered a "benign" entity, RLS/WED has been related to sleep and emotional disorders that may affect quality-of-life measures deleteriously [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Longitudinal Cognitive Trajectories in Older Adults with Restless Legs Syndrome or Willis–Ekbom Disease

Liampas,

Siokas,

Kyrozis

et al. 2024

Life

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Background: Restless legs syndrome/Willis–Ekbom disease (RLS/WED) has occasionally but not consistently been associated with cognitive and most notably language and executive impairment. The present study was conducted to investigate the cognitive trajectories of older individuals with RLS/WED. Methods: Participants were drawn from the randomly selected, older (>64 years), population-based HELIAD cohort. Individuals without dementia and with available neuropsychological evaluations at baseline and follow-up were considered for potential eligibility. A comprehensive assessment examining five principal components of cognition (memory, visuo-spatial ability, attention, executive function, and language) was administered to the participants. Generalized estimating equation analyses were used to examine the unadjusted and adjusted (for critical factors and covariates) effects of RLS/WED on cognition over time. Results: A total of 1003 predominantly female (59.5%), older (72.9 ± 4.9 years) participants with follow-up evaluations after a mean of 3.09 ± 0.85 years and without dementia at baseline and follow-up were included in the present study. Among them, 81 were diagnosed with RLS/WED at baseline. Global cognition, memory, attention, and executive and visuo-perceptual skills did not differ between those with and without RLS/WED. However, the RLS/WED group performed worse on language at baseline by a standard deviation of 0.249, while demonstrating a mitigated language decline over time, by a standard deviation of 0.063. The unadjusted models yielded similar results. Conclusions: Our findings were indicative of a baseline language disadvantage among older individuals with RLS/WED, but the initial discrepancy tends to dissolve over time.

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Restless Leg Syndrome: Pathophysiology, Diagnostic Criteria, and Treatment

Cited by 7 publications

References 15 publications

The Obesity-Related Dietary Pattern Is Associated with Higher Risk of Sleep Disorders: A Cross-Sectional Study from NHANES

The Obesity-Related Dietary Pattern Is Associated with Higher Risk of Sleep Disorders: A Cross-Sectional Study from NHANES

An Unusual Case of an Acute Episode of Restless Leg Syndrome Following Oral Metoclopramide Therapy

Longitudinal Cognitive Trajectories in Older Adults with Restless Legs Syndrome or Willis–Ekbom Disease

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