Restless legs syndrome: An overview of pathophysiology, comorbidities and therapeutic approaches (Review)

Vlasie, Andrei; Trifu, Simona; Lupuleac, Cristiana; Kohn, Bianca; Cristea, M

doi:10.3892/etm.2021.11108

Cited by 43 publications

(43 citation statements)

References 95 publications

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“…При этом повышается уровень индуцируемого гипоксией фактора 1α (HIF-1α) в черной субстанции мозга у больных СБН, а в сосудах мозга увеличивается и образование HIF-2α. Эти факторы обеспечивают адаптацию метаболизма к гипоксическим состояниям, и следствием таких изменений метаболизма является увеличение дофаминергической активности у больных с СБН [29]. Гипоксический путь активации дофаминергической системы объясняет высокую частоту СБН у пациентов с хронической обструктивной болезнью легких (ХОБЛ) [30].…”

Section: общая характеристика синдрома беспокойных ногunclassified

“…Процесс формирования миелиновой оболочки также зависит от железа. У пациентов с СБН было описано снижение плотности белого вещества в области мозолистого тела, передней поясной коре и прецентральной извилине [29].…”

Section: лекции и обзоры | Lectures and Reviewsunclassified

“…Не исключено, что механизм развития СБН будет разным в зависимости от особенностей патогенеза основного заболевания. Например, при ХОБЛ существенную роль играет гипоксия, запускающая гиперактивацию дофаминовой системы, как и в случае с анемией [29], а при СКВ -наличие аутоантител к дофаминергическим нейронам [42].…”

Section: синдром беспокойных ног и анемия хронического воспаленияunclassified

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Anemia in patients with inflammatory bowel disease as a risk factor for restless legs syndrome. Literature review

Zakharova

Калинкин

2022

Neuromuscular Diseases

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Restless legs syndrome (RLS) is a neurological, sensorimotor disorder. It is characterized by the uncomfortable and unpleasant sensations in the legs which begin or worsen during periods of rest, primarily in the evening or night, and are relieved by movement. Central iron deficiency plays a vital role in the pathogenesis of RLS. There is evidence that chronic inflammation is an additional risk factor for RLS. Anemia is the most common complication and extraintestinal manifestation of inflammatory bowel disease, therefore the prevalence of RLS in these patients is a problem of great interest. In addition, inflammatory bowel disease patients’ sleep disturbances directly influence the disease’s clinical course and can be the preclinical marker of exacerbation. It is essential for clinicians to be aware of RLS as a possible reason for sleep disturbance and as a factor that negatively affects the quality of life in inflammatory bowel disease patients.

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Section: общая характеристика синдрома беспокойных ногunclassified

Section: лекции и обзоры | Lectures and Reviewsunclassified

Section: синдром беспокойных ног и анемия хронического воспаленияunclassified

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Anemia in patients with inflammatory bowel disease as a risk factor for restless legs syndrome. Literature review

Zakharova

Калинкин

2022

Neuromuscular Diseases

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“…In addition, excessive daytime sleepiness with sleep attacks particularly in patients with comorbid parkinsonism, impulse control disorder symptoms, as well as dose related adverse effects, such as dizziness and drowsiness may develop in patients on dopamine agonist medications. Second-line therapies include intravenous iron infusion in those who are intolerant of oral iron intake and/or those having augmentation with intense, severe RLS symptoms, and opioids including tramadol, oxycodone, and methadone [8,9,10].…”

Section: Introductionmentioning

confidence: 99%

Restless Legs Syndrome in Chronic Kidney Disease- a Systematic Review

Safarpour¹,

Vaziri²,

Jabbari

2023

Tremor and Other Hyperkinetic Movements

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Objectives:The objective of this review is to provide updated information on the epidemiology, correlating factors and treatment of chronic kidney disease associated restless legs syndrome (CKD-A-RLS) in both adult and pediatric population. Materials and Methods:We have reviewed the Medline search and Google Scholar search up to May 2022, using key words restless legs syndrome, chronic kidney disease and hemodialysis and kidney transplant. The reviewed articles were studied for epidemiology, correlating factors, as well as pharmacologic and non-pharmacologic treatment options.Results: Our search revealed 175 articles, 111 were clinical trials or cross-sectional studies and 64 were review articles. All 111 articles were retrieved and studied in detail. Of these, 105 focused on adults and 6 on children. A majority of studies on dialysis patients reported a prevalence between 15-30%, which is notably higher than prevalence of RLS in general population (5-10%). The correlation between presence of CKD-A-RLS with age, gender, abnormalities of hemogram, iron, ferritin, serum lipids, electrolytes and parathyroid hormones were also reviewed. The results were inconsistent and controversial. Limited studies have reported on the treatment of CKD-A-RLS. Non-pharmacological treatment focused on the effect(s) of exercise, acupuncture, massage with different oils and infra-red light whereas, pharmacologic treatment options include the effects of dopaminergic drugs, Alpha2-Delta ligands (gabapentin and pregabalin), vitamins E and C, and intravenous iron infusion. Conclusion:This updated review showed that RLS is two to three times more common in patients with CKD compared to the general population. More patients with CKD-A-RLS demonstrated increased mortality, increased incidence of cardiovascular accident, depression, insomnia and impaired quality of life than those with CKD without RLS. Dopaminergic drugs such as levodopa, ropinirole, pramipexole and rotigotine as well as calcium channel blockers (gabapentin and pregabalin) are helpful for treatment of RLS. High quality studies with these agents are currently underway and hopefully confirm the

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“… 1 Despite being termed restless legs , urges can occur in other locations (arms, neck, face torso, etc), 2 although involvement of the legs is essential for diagnosis. 3 The pathophysiology of RLS in people with kidney impairment is not well understood. The diagnosis can be made if all of the following 5 criteria are met (International RLS Study Group [IRLSSG] diagnostic criteria [ Table 1 ]) 4 :…”

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confidence: 99%