Restless Legs Syndrome and Painful Neuropathy—Retrospective Study. A Role for Nociceptive Deafferentation?: Table 1

Abstract

RLS is frequent in painful polyneuropathy and is significantly associated with decreased small fiber input, thus nociceptive deafferentation may represent a factor interacting with RLS "generators," possibly at spinal level. We suggest that overactivity of the spinal structures implicated in RLS may be triggered by nociceptive deafferentation in a subgroup of patients with painful polyneuropathy. Our findings, prompting a mechanistic characterization of RLS associated with painful polyneuropathy, have to be confirmed in a prospective study.

Neuropathy in a cohort of restless leg syndrome patients

“…In a study of 104 patients with miscellaneous peripheral neuropathy, RLS was reported in 29% of patients compared to 14.9% of the neurological controls [7]. A higher prevalence of RLS (42.2%) was reported in another retrospective review of neuropathy patients with the main manifestations being pain and dysesthesia, [10] and an even higher prevalence of 54% was reported in a selected cohort of neuropathy patients with primary sensory and uncomfortable symptoms [5]. In our study, DSPN due to diabetes mellitus was most frequently associated with RLS and two patients had demyelinating neuropathy.…”

“…Additionally, in some neuropathy patients, neuropathic symptoms are also worse at night. RLS has been reported with a number of neuropathies such as diabetes mellitus, renal failure, Charcot-Marie-Tooth disease, cryoglobulinemia and various painful neuropathies [4,5,[7][8][9][10][11]. RLS is thought to be more common in small fiber, painful neuropathies compared to large fiber neuropathies (54% versus 5.2%, respectively) [4,5].…”

Integrating Sleep Management into Clinical Practice

“…Risk factors for RLS include family history, with several genetic loci having been mapped (Cochen De Cock & Dauvilliers, 2010), pregnancy (Neau et al, 2010), end stage renal disease (Enomoto, Inoue, Namba, Munezawa, & Matsuura, 2007), low ferritin levels (Mizuno, Mihara, Miyaoka, Inagaki, & Horiguchi, 2005) and neuropathy (Gemignani, Brindani, Vitetta, & Marbini, 2009). Sometimes certain antidepressants, especially the newer second generation ones, can exacerbate RLS (Khalid, Rana, Khalid, & Roehrs, 2009).…”

Increased Frequency of Restless Legs Syndrome in Myasthenia Gravis

“…From the other side this result is comparable to the prevalence of RLS in other neurological and non-neurological disease patients. Prevalence of RLS in previously published studies ranges from 36.6 to 62% [6,10,11,12,22,23]. The prevalence of RLS was also high in the control group.…”