Restless legs syndrome and post polio syndrome: a case−control study

Romigi, Andrea; Pierantozzi, Mariangela; Placidi, Fabio; Evangelista, Elisa; Albanese, Maria; Liguori, Claudio; Nazzaro, Marco Stefano; Risina, B. U.; Simonelli, V.; Izzi, Francesca; Mercuri, Nicola Biagio; Desiato, M.T.

doi:10.1111/ene.12593

Cited by 17 publications

(19 citation statements)

References 54 publications

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“…A sleep study may be required to assess for sleep‐related breathing disorders/sleep apnea. Restless leg syndrome is common in postpolio individuals, with a reported prevalence of 36% among postpolio patients at an outpatient neuromuscular clinic, and may also impact sleep and energy level . Creatine kinase level may be moderately elevated in individuals with poliomyelitis but is not specific for PPS and cannot reliably distinguish between patients with or without PPS .…”

Section: Investigationsmentioning

confidence: 99%

“…Restless leg syndrome is common in postpolio individuals, with a reported prevalence of 36% among postpolio patients at an outpatient neuromuscular clinic, and may also impact sleep and energy level. [129][130][131] Creatine kinase level may be moderately elevated in individuals with poliomyelitis but is not specific for PPS and cannot reliably distinguish between patients with or without PPS. 132,133 Results of the clinical evaluation will indicate whether other medical conditions such as depression, cardiorespiratory disease, inflammatory conditions (e.g., rheumatoid arthritis), chronic pain disorders/fibromyalgia, or medications or lifestyle factors may be responsible for or exacerbate the fatigue and/or pain, and additional investigations, management, or consultations may be required.…”

Section: Investigationsmentioning

confidence: 99%

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Postpolio syndrome and the late effects of poliomyelitis. Part 1. pathogenesis, biomechanical considerations, diagnosis, and investigations

Robinson

2018

Muscle and Nerve

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Postpolio syndrome (PPS) is characterized by new muscle weakness and/or muscle fatigability that occurs many years after the initial poliomyelitis illness. Many theories exist regarding the pathogenesis of PPS, which remains incompletely understood. In contrast, the late effects of poliomyelitis are often a consequence of biomechanical alterations that occur as a result of polio-related surgeries, musculoskeletal deformities, or weakness. Osteoporosis and fractures of the polio-involved limbs are common. A comprehensive clinical evaluation with appropriate investigations is essential to fulfilling the established PPS diagnostic criteria. PPS is a diagnosis of exclusion in which a key clinical feature required for the diagnosis is new muscle weakness and/or muscle fatigability that is persistent for at least 1 year. Electromyographic and muscle biopsy findings including evidence of ongoing denervation cannot reliably distinguish between patients with or without PPS. Muscle Nerve, 2018.

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Section: Investigationsmentioning

confidence: 99%

Section: Investigationsmentioning

confidence: 99%

Postpolio syndrome and the late effects of poliomyelitis. Part 1. pathogenesis, biomechanical considerations, diagnosis, and investigations

Robinson

2018

Muscle and Nerve

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“…The fatigue severity scale score was significantly higher in patients with post‐polio syndrome who had RLS. The SF‐36 survey results of these patients showed that the physical role, physical function, and subdomains of body pain were negatively affected . In our study, we found that sleep quality was also negatively affected in patients with poliomyelitis who also had RLS diagnosis.…”

Section: Discussionmentioning

confidence: 48%

“…The neuroanatomical similarities between central‐spinal areas affected by poliomyelitis and areas that play a role in RLS development suggest that these patients have a higher risk for RLS development. According to the literature, there are only a limited number of studies or case reports on the association between RLS and poliomyelitis. The aim of this study was to assess the presence of RLS in patients with poliomyelitis, and associated factors.…”

Section: Introductionmentioning

confidence: 99%

Restless leg syndrome and associated factors in patients with paralytic poliomyelitis

Terzi

Yılmaz

2015

Sleep and Biological Rhythms

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The aim of this study was to assess the presence of Restless Leg Syndrome (RLS) in patients with poliomyelitis, and associated factors. Forty-six patients with paralytic poliomyelitis who were followed-up in 2014 were included in the study. The RLS diagnosis was made according to the survey forms by International Restless Legs Syndrome Study Group. The RLS rating scale was used to rate the disease severity. The Pittsburgh sleep quality index (PSQI) was used to assess sleep quality. The Beck depression inventory was used in order to evaluate depression. Forty-six patients (30 males, 16 females) were included in the study. The mean age was 54.1 ± 5.8 years. Eighteen patients (39.1%) were diagnosed with RLS. For patients with RLS, the mean age at poliomyelitis onset was 2.4 ± 1.1 years; on the other hand, the mean age at poliomyelitis onset was 6.8 ± 3.8 years for patients without RLS (P = 0.03). Bilateral extremity involvement was detected in four patients with RLS, and one patient without RLS (P = 0.01). We did not find a significant difference in depression scores between the groups (P = 0.541). The PSQI score was significantly higher in RLS patients (P = 0.01). RLS is more common in patients with poliomyelitis, compared to the general population. Patients, especially those who have bilateral lower extremity involvement and low age at poliomyelitis onset, might be at risk for RLS development. Further studies are required to evaluate the mechanisms that could explain RLS development and disease-associated factors.

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“…Although each is non-specific, it has been proposed that, when used in combination and together with imaging, the specificity for detecting early PD may be increased significantly. Dystonia and other movement disorders are now attracting increasing attention in terms of treatment, particularly with non-medical forms including deep brain stimulation [118][119][120][121][122][123][124][125][126][127][128][129][130][131][132][133].…”

mentioning

confidence: 99%

Advances in neurological research and practice

Schapira¹

2016

Euro J of Neurology

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Restless legs syndrome and post polio syndrome: a case−control study

Abstract: Our findings demonstrate a high prevalence of RLS in PPS, and that RLS occurrence may significantly influence the HRQoL and fatigue of PPS patients. A hypothetical link between neuroanatomical and inflammatory mechanisms in RLS and PPS is suggested.

Cited by 17 publications

References 54 publications

Postpolio syndrome and the late effects of poliomyelitis. Part 1. pathogenesis, biomechanical considerations, diagnosis, and investigations

Postpolio syndrome and the late effects of poliomyelitis. Part 1. pathogenesis, biomechanical considerations, diagnosis, and investigations

Restless leg syndrome and associated factors in patients with paralytic poliomyelitis

Advances in neurological research and practice

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