Restless Legs Syndrome During Pregnancy and 12 Weeks Postpartum and Its Links to Cardiovascular Diseases, Stressful Life Events, and Psychiatric History

Goecke, Tamme W.; Schnakenberg, Patricia; Frensch, Markus; Chechko, Natalia

doi:10.3390/jcm9093046

Cited by 12 publications

(9 citation statements)

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“…[ 31 ] However, in our study, no significant relationships were seen between RLS during pregnancy and complications and outcomes of pregnancy, including the incidence of emergency LSCS, prematurity, low birthweight, GDM, and PIH, unlike other studies which reported a positive association between RLS and GDM and PIH. [ 32 ]…”

Section: Discussionmentioning

confidence: 99%

Prevalence of restless legs syndrome in pregnant women in Oman and its effect on pregnancy and neonatal outcomes

Shidhani

Rawahi

Yahiyai

et al. 2022

Journal of Family and Community Medicine

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BACKGROUND: Restless legs syndrome (RLS) is a common sensorimotor disorder during pregnancy. The purpose of this study was to assess the prevalence of RLS and explore the associated risk factors and outcomes in Omani women in the first and third trimester and at 2-week postpartum. MATERIALS AND METHODS: This cross-sectional study included 305 pregnant women visiting four health centers in Muscat between May 2018 and October 2020. A structured questionnaire was used and data were collected through review of electronic records and face-to-face interviews. The International RLS Study Group criteria were used to diagnose RLS. Participants were interviewed during their first trimester, their third trimester, and at their 2-week postpartum visit. Results were presented as means and standard deviations or percentages, as appropriate. To assess the association between RLS and various variables, unpaired t -test or McNemar's test were used, as appropriate. RESULTS: The mean age at baseline was 29.8 ± 5.28 years. The prevalence of RLS was significantly higher in the third trimester (41.0%) than in the first trimester (15.7%) and postpartum period (15.1%) ( P < 0.001), although there was no significant difference in severity. Family history and personal history of RLS were the only independent correlates of RLS ( P < 0.001 and 0.002, respectively). No associations were noted with pregnancy and neonatal outcomes or other comorbidities, including anemia. However, there was a significant relationship between the development of RLS and weight gain during pregnancy ( P = 0.023). CONCLUSION: One in six pregnant Omani women may be at risk of RLS during the first trimester, while one in 2–3 may be at risk in the third trimester, particularly those with a personal or family history of RLS and those who gain >12 kg during pregnancy.

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Section: Discussionmentioning

confidence: 99%

Prevalence of restless legs syndrome in pregnant women in Oman and its effect on pregnancy and neonatal outcomes

Shidhani

Rawahi

Yahiyai

et al. 2022

Journal of Family and Community Medicine

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“…The primary occurrence of RLS during pregnancy represents a risk factor for developing RLS later in life (4‐fold increase) or in the following pregnancies. European Research Groups in Switzerland, Italy, Slovakia, Germany published in the past years new data regarding the prevalence and management of RLS during pregnancy (Cesnik et al, 2010; Garbazza & Manconi, 2018; Goecke, Schnakenberg, Frensch, & Chechko, 2020; Manconi et al, 2004; Minar, Habanova, Rusnak, Planck, & Valkovic, 2013; Silvestri & Aricò, 2019).…”

Section: Epidemiology Of Rlsmentioning

confidence: 99%

Restless legs syndrome: Over 50 years of European contribution

Khachatryan

Ferri

Fulda

et al. 2022

Journal of Sleep Research

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Summary Restless legs syndrome (RLS) is a sensorimotor neurological disorder characterised by an urge to move the limbs with a circadian pattern (occurring in the evening/at night), more prominent at rest, and relieved with movements. RLS is one of the most prevalent sleep disorders, occurring in 5%–10% of the European population. Thomas Willis first described RLS clinical cases already in the 17th century, and Karl‐Axel Ekbom described the disease as a modern clinical entity in the 20th century. Despite variable severity, RLS can markedly affect sleep (partly through the presence of periodic leg movements) and quality of life, with a relevant socio‐economic impact. Thus, its recognition and treatment are essential. However, screening methods present limitations and should be improved. Moreover, available RLS treatment options albeit providing sustained relief to many patients are limited in number. Additionally, the development of augmentation with dopamine agonists represents a major treatment problem. A better understanding of RLS pathomechanisms can bring to light novel treatment possibilities. With emerging new avenues of research in pharmacology, imaging, genetics, and animal models of RLS, this is an interesting and constantly growing field of research. This review will update the reader on the current state of RLS clinical practice and research, with a special focus on the contribution of European researchers.

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“…RLS is associated with various pregnancy complications, including pregnancy-induced hypertension (6)(7)(8), cardiovascular disease (6)(7)(8)(9), gestational diabetes (10,11), sleep disorders (12, 13), poor quality of life, and depression (14)(15)(16). These issues can contribute to adverse pregnancy outcomes such as preterm birth (17, 18), miscarriage (19), low birth weight (8,18), postpartum depression (20), and baby blues (9). Furthermore, RLS increases the risk of recurrence, chronicity, and cardiovascular disease (21,22).…”

Section: Introductionmentioning

confidence: 99%

“…Factors associated with RLS include female gender, pregnancy, lower socioeconomic status, poor health, low iron levels, and advanced age, comorbidity with Parkinson's disease or psychiatric disorders, and family history of similar disorders (16,32). During pregnancy, variables such as taking prophylactic iron supplementation (11, 33), a history of premenstrual syndrome (9), chronic diabetes mellitus (21), later gestational age (34), poor sleep quality, stressful life events, and excessive daytime sleepiness (7) have also been associated with RLS.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and factors associated with restless legs syndrome among pregnant women in middle-income countries: a systematic review and meta-analysis

Mislu,

Assalfew,

Arage

et al. 2023

Front. Med.

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IntroductionRestless legs syndrome (RLS) is a debilitating condition characterized by uncomfortable sensations in the legs, typically occurring during periods of rest or sleep. It is more prevalent during pregnancy and is linked to sleep disturbances, diminished quality of life, and pregnancy complications. However, previous studies yielded inconsistent findings among pregnant women in middle-income countries. Consequently, this systematic review and meta-analysis sought to determine the pooled prevalence of restless legs syndrome and its associated factors in these populations.MethodA systematic review and meta-analysis was conducted on published studies from middle-income countries until May 2023. The review strictly adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Relevant search terms were used to search for studies in PubMed, MEDLINE, EMBASE, and Google Scholar. Data extraction was performed using the Joanna Briggs Institute tool for prevalence studies. The meta-analysis was conducted using STATA 17 software, and heterogeneity was assessed using the I2 test, while publication bias was evaluated using Egger's test. Forest plots were also used to present the pooled prevalence and odds ratio (OR) with a 95% confidence interval (CI) using the random-effects model.ResultThis review included 22 studies from nine countries with a total of 17, 580 study participants. The overall pooled prevalence of RLS among pregnant women in middle-income countries was 13.82% (95% CI: 13.31, 14.32), and having low hemoglobin level (AOR: 1.68, 95% CI: 1.29, 2.18), history of RLS (AOR: 7.54, 95% CI: 3.02, 18.79), muscle cramps (AOR: 3.58, 95% CI: 1.21, 10.61), excessive day time sleepiness (AOR: 4.02, 95% CI: 1.34, 12.04), preeclampsia (AOR: 2.06, 95% CI: 1.28, 3.30), and taking prophylactic iron supplementation (AOR: 0.59, 95% CI: 0.50, 0.69) were the identified factors associated with it.ConclusionGenerally, nearly one in every eight pregnant women in middle-income countries develop restless legs syndrome during pregnancy. Having low hemoglobin level, a history of RLS, muscle cramps, excessive daytime sleepiness, preeclampsia, and taking prophylactic iron supplementation were the identified factors associated with it. These findings underscore the importance of addressing the identified factors associated with RLS in order to effectively mitigate its occurrence among pregnant women.

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Restless Legs Syndrome During Pregnancy and 12 Weeks Postpartum and Its Links to Cardiovascular Diseases, Stressful Life Events, and Psychiatric History

Cited by 12 publications

References 56 publications

Prevalence of restless legs syndrome in pregnant women in Oman and its effect on pregnancy and neonatal outcomes

Prevalence of restless legs syndrome in pregnant women in Oman and its effect on pregnancy and neonatal outcomes

Restless legs syndrome: Over 50 years of European contribution

Prevalence and factors associated with restless legs syndrome among pregnant women in middle-income countries: a systematic review and meta-analysis

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