Restless legs syndrome in an Asian population: A study in Singapore

Tan, Eng King; Seah, A.; See, Siew Ju; Lim, Edwin Choon-Wyn; Wong, Michael; Koh, Keith

doi:10.1002/mds.1102

Cited by 252 publications

(147 citation statements)

References 12 publications

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“…The reported prevalence of RLS in European countries ranges between 5% and 15%, whereas it is considerably low, 0.1-2.3%, in Asian countries (20). The prevalence of RLS was found to be 3.4% in the western Black Sea coast of Turkey (21).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Restless Legs Syndrome among Psoriasis Patients and Association with Depression and Sleep Quality

Bilgiç¹,

Karaman²,

Bozkurt³

et al. 2016

tdd

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Objective: Restless legs syndrome (RLS) is a chronic disorder characterized by an urge to move the legs. In the present study, we investigated the frequency of RLS in patients with psoriasis and tried to obtain the effects of RLS on sleep quality and psychiatric wellbeing. Methods: A total of 114 consecutive psoriasis patients (60 women and 54 men) and 67 control subjects who attended the Department of Dermatology and Venereology were enrolled in the study. A diagnosis of RLS was made according to the criteria of the International RLS Study Group (IRLSSG), and severity was assessed using the IRLSSG severity scale. Sixty-seven of 114 patients answered the Turkish version of Beck Depression Inventory (BDI) and Pittsburgh Sleep Quality Index. Results: We found a higher frequency of RLS in psoriasis patients (11.4%) compared to healthy controls (6.0%), but this prevalence has not reached a statistical significance (p=0.23). Body mass index, BDI score, and bad sleep quality were significantly higher in psoriasis patients compared to healthy controls. Conclusion: Since presence of RLS worsens psoriasis patients' already bad quality of life, we suggest screening of patients for the presence of RLS, and directing them to a rheumatologist can improve their quality of life.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Restless Legs Syndrome among Psoriasis Patients and Association with Depression and Sleep Quality

Bilgiç¹,

Karaman²,

Bozkurt³

et al. 2016

tdd

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“…2-4 A prevalence of 5% to 15% has been reported in United States and Europe 5-7 with lower prevalence rates (< 5%) in Asian populations. 8 Epidemiologic studies have suggested an association between RLS and cardiovascular diseases, Parkinson disease, erectile dysfunction, poor sleep, and depressive symptoms. 9-11 The burden of RLS on quality of life 12 is comparable to that of other chronic illnesses such as diabetes, arthritis, hypertension, and acute myocardial infarction.…”

Section: Introductionmentioning

confidence: 99%

Lifestyle factors and risk of restless legs syndrome: Prospective Cohort study

Batool-Anwar

Vito

et al. 2013

Sleep Medicine

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Study Objectives: To examine the association between modifiable lifestyle factors, and the risk of developing restless legs syndrome (RLS). Methods: This is a Prospective Cohort study of population including 12,812 men participating in Health Professionals Follow-up Study and 42,728 women participating in the Nurses' Health study II. The participants were free of RLS at baseline (2002 for the HPFS and 2005 for the NHS II) and free of diabetes and arthritis through follow-up. RLS was assessed via a set of questions recommended by International Restless Legs Syndrome Study group. The Information was collected on height, weight, level of physical activity, dietary intake, and smoking status via questionnaires. Results: During 4-6 years of follow-up, we identified 1,538 incident RLS cases. Participants with normal weight, and who were physically active, non-smoker, and had some alcohol consumption had a lower risk of developing RLS. When we combined the effects of these four factors together, we observed a dose response relationship between the increased number of healthy lifestyle factors and a low risk of RLS: after adjusting for potential confounders the pooled odds ratio was 0.67 (95% CI: 0.47-0.97) for 4 vs.0 healthy factors (p trend < 0.001). In contrast, we did not observe significant associations between caffeine consumption or diet quality as assessed by the Alternate Healthy Eating Index, and altered RLS risk in men and women. I NTRO DUCTI O NRestless legs syndrome (RLS), a debilitating illness that has affected people over the centuries, 1 is characterized by unpleasant sensations and an irresistible urge to move the legs. 2-4 A prevalence of 5% to 15% has been reported in United States and Europe 5-7 with lower prevalence rates (< 5%) in Asian populations. 8 Epidemiologic studies have suggested an association between RLS and cardiovascular diseases, Parkinson disease, erectile dysfunction, poor sleep, and depressive symptoms. 9-11 The burden of RLS on quality of life 12 is comparable to that of other chronic illnesses such as diabetes, arthritis, hypertension, and acute myocardial infarction. 3 The etiology of RLS is not known; however, several pathophysiologic mechanisms have been reported. Age and genetics are important determinants of clinical expression for primary RLS, 13-15 whereas secondary RLS is present in a variety of conditions including iron deficiency, diabetes, renal failure, Parkinson disease, and pregnancy. Lifestyle factors such as lack of physical activity, obesity, cigarette smoking, alcohol intake, and consumption of coffee have also been postulated to have an effect on the risk or severity of RLS. 13 However, the evidence linking these factors to RLS is based on small studies (n = 41), 16 and the use of different methodologic and diagnostic criteria, and the lack of control for covariates, has resulted in conflicting results. We thus prospectively examined the associations between lifestyle factors (i.e., obesity, physical activity, overall diet quality, smoking, and alcohol intake)...

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“…3 A prevalence of 0.1% has been observed in Singapore, 34 3.19% in Turkey, 35 6.77% in Mozambique (Africa), 36 and 6.4% in Brazil. 37 The different prevalence rates observed in epidemiological studies were probably due to many factors such as ethnic composition of the population, environmental influence, and also the methodology used to obtain the data.…”

Section: Restless Legs Syndromementioning

confidence: 99%

Migraine and restless legs syndrome: current perspectives

Ferreira¹,

Dach²,

Éckeli³

et al. 2015

JPRLS

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Abstract:The relationship between migraine and restless legs syndrome (RLS) has been described in the literature for some years, based on clinical findings and pathophysiological considerations. There are some possible factors relating migraine and RLS. Both are diseases involving the central nervous system, the two diseases seem to share a dopaminergic mechanism, and it is also believed that they may share a genetic origin. At present, doctors who work with these two diseases should be encouraged not to simply investigate the simultaneous presence of both, but should also apply a treatment better adapted to this possibility. Research should be directed at some still unanswered questions for a better understanding of the association between migraine and RLS.

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Restless legs syndrome in an Asian population: A study in Singapore

Cited by 252 publications

References 12 publications

Prevalence of Restless Legs Syndrome among Psoriasis Patients and Association with Depression and Sleep Quality

Prevalence of Restless Legs Syndrome among Psoriasis Patients and Association with Depression and Sleep Quality

Lifestyle factors and risk of restless legs syndrome: Prospective Cohort study

Migraine and restless legs syndrome: current perspectives

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