Restless Legs Syndrome in an Elderly Patient Induced by Combined Use of Low Dose Quetiapine and Citalopram

Buturak, Şadiye Visal; Yazıcı, Kemal Utku; Yazıcı, Ayça Cordan; Tot, Şenel; Başterzi, Ayşe Devrim

doi:10.5455/bcp.20120729090847

Cited by 5 publications

(5 citation statements)

References 24 publications

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“…A previous study revealed that quetiapine at doses of 200–600 mg/d induced RLS [ 18 ]. Another case pointed out that quetiapine at a low dose (50 mg/d) also resulted in RLS in a 75-year-old woman with insomnia [ 19 ]. Furthermore, RLS presented at very small to moderate doses (25–250 mg) in patients with affective disorders on treatment with antidepressants and quetiapine [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Transitory restless arms syndrome in a patient with antipsychotics and antidepressants: a case report

et al. 2021

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Background Restless arms syndrome (RAS) is characterized by uncomfortable aching or burning sensations in the arms. RAS is regarded as an upper limb variant of restless legs syndrome (RLS). The lack of specific diagnostic criteria makes it difficult to recognize the RAS. Therefore, RAS is usually neglected in clinical practice. Moreover, when a patient was diagnosed with RAS, the adjustment of medications was the first choice for doctors, which may make the patient’s condition unstable. Case presentation A 33-year-old woman was diagnosed with schizophrenia and major depressive disorder. Starting with 0.6 g/d amisulpride, 0.1 g/d quetiapine, 75 mg/d venlafaxine sustained-release tablets, the patient reported symptoms of RAS (itching arms) on the fourth day since the latest hospitalization. After ruling out other factors, her RAS was suspected to be induced by antidepressants or antipsychotics. Without medication adjustment, RAS spontaneously remitted. Conclusions This case suggests that psychiatrists should pay attention to RAS when using antipsychotics and/or antidepressants. Moreover, RAS may be transitory. When a patient manifests RAS, observation may be one choice instead of an immediate medication adjustment.

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Section: Discussionmentioning

confidence: 99%

Transitory restless arms syndrome in a patient with antipsychotics and antidepressants: a case report

et al. 2021

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“…One elderly patient developed RLS symptoms after addition of 50 mg/d quetiapine to preexisting 20 mg/d citalopram treatment. Another patient developed RLS after a single dose of quetiapine was added to preexisting low-dosed paroxetine (Buturak, & Yazici, 2012). One patient developed RLS after combination therapy with lithium and quetiapine but symptoms were reduced by changing the times of administration without reducing the dose of quetiapine (Demirci, & Sert, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Beyond this, multiple drugs have been described to induce or to exacerbate RLS, among them dopamine D2 receptor antagonists, histamine receptor antagonists, antidepressants, lithium, beta blockers, alcohol and caffeine (Satija, & Ondo, 2008). Dopaminergic dysfunction and a change in the regulation of iron homeostasis can lead to iron depletion in the central nervous system and are thought to be involved in the pathophysiology of RLS (Buturak, & Yazici, 2012). Drug-induced RLS remains an underdiagnosed condition, although it is associated with sleep deprivation, substance abuse and medication non-adherence (Michopoulos, & Ferentinos, 2014).…”

Section: Restless Legs Syndrome Associated With Quetiapine In Elderlymentioning

confidence: 99%

Restless Legs Syndrome Associated with Quetiapine in Elderly Patient

Siddiqui¹,

Qureshi²,

Alghamdi³

2017

Sleep Hypn

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Restless legs syndrome (RLS) is a sleep-related disorder characterized by abnormal sensations in the legs at rest in which the patients feel an urge to move the legs; beginning or worsening during inactivity; relief by movement; preponderance in evening or night. The drugs implicated were mainly psychotropic, especially neuroleptics and many others. Drug induced RLS generally resolves when the dose is reduced or the drug is withdrawn. We report a case of bipolar mood disorder presented to our emergency department with insomnia and we added quetiapine 100mg at bed time for his disturbed sleep, patient reported on third day complaining with "itchy", "Pins and needles", "creepy crawly" feeling in the legs. The sensations are usually worse at rest and night due to which he is unable to sleep. Awareness and proper diagnosis by all primary care practitioners is necessary for effective management of RLS as well as clinicians are encourage to be aware of the potential for quetiapine to cause RLS.

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“…Dopaminergic dysfunction and a change in the regulation of iron homeostasis can lead to iron depletion in the central nervous system and are thought to be involved in the pathophysiology of RLS [1]. Drug-induced RLS J Psychiatry Psychiatric Disord 2016; 1 (1): 41-44 43 remains an underdiagnosed condition, although it is associated with sleep deprivation, substance abuse and medication non-adherence [2].…”

Section: Discussionmentioning

confidence: 99%

“…One elderly patient developed RLS symptoms after addition of 50 mg/d quetiapine to preexisting 20 mg/d citalopram treatment. Another patient developed RLS after a single dose of quetiapine was added to preexisting low-dosed paroxetine [1]. One patient developed RLS after combination therapy with lithium and quetiapine but symptoms were reduced by changing the times of administration without reducing the dose of quetiapine [4].…”

Section: Discussionmentioning

confidence: 99%

Quetiapine XR and Restless Legs Syndrome

Brennan¹

2017

J Psychiatry Psychiatric Disord

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Restless Legs Syndrome (RLS) is a common condition associated with many medical illnesses and medications.Psychotropic medications (both antidepressants and antipsychotics) may be causal. There have been over twenty cases of RLS due to Quetiapine but no published case reports linking RLS to Quetiapine XR. We present the case of a woman with previously established Bipolar Disorder who presented with RLS following the administration of three doses of Quetiapine XR. RLS occurred after administration of the medication and stopped upon discontinuation. She was taking no other medications, had no other acute medical comorbidities, and had not been abusing substances. Clinicians are encouraged to be aware of the potential for Quetiapine XR to cause RLS. Further studies are needed.

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Restless Legs Syndrome in an Elderly Patient Induced by Combined Use of Low Dose Quetiapine and Citalopram

Cited by 5 publications

References 24 publications

Transitory restless arms syndrome in a patient with antipsychotics and antidepressants: a case report

Transitory restless arms syndrome in a patient with antipsychotics and antidepressants: a case report

Restless Legs Syndrome Associated with Quetiapine in Elderly Patient

Quetiapine XR and Restless Legs Syndrome

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