Restless legs syndrome in end stage renal disease patients undergoing hemodialysis

Lin, Xiao Wei; Zhang, Jun Fang; Qiu, Meng Yao; Ni, Ling; Yu, Hong; Kuo, Sheng Han; Ondo, William G.; Yu, Qing; Wu, Yun

doi:10.1186/s12883-019-1265-y

Cited by 36 publications

(44 citation statements)

References 42 publications

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“…In addition; age and co-morbidity as diabetes mellitus were associated with severity of RLS symptoms. Also this study is contradicting with Lin , Zhang , Qiu , Ni , Yu , Ku , Ondo , Yu and Wu (2019), who reported that RLS is more frequent in female gender with end stage renal disease; so the correlation between biosocio-demographic characteristics still contentious.…”

Section: Discussioncontrasting

confidence: 92%

“…This results is consistent with Kaur, Venkateasan, Kaur, Rawat, Massey(2016), who revealed that; no significant association between the pre RLS rating scale score with personal characteristics as sex, age, type of family, level of education, marital status, occupation, religion, frequency of dialysis per week, and duration of dialysis per cycle, except income and personnel habits. Also; Lin , Zhang , Qiu , Ni , Yu , Ku , Ondo , Yu and Wu (2019) found no meaningful association between RLS and the period of hemodialysis. The present results also supported by (Salman, 2011), who concluded that; RLS wasn't significantly correlated to age, and there was no significant difference in sex or duration of dialysis between the study participants.…”

Section: Discussionmentioning

confidence: 88%

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Effect of Muscles Stretching Exercises on Severity of Restless Legs Syndrome of Adult Patients Undergoing Hemodialysis

2019

JHMN

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The patients undergoing hemodialysis usually have several complications including restless leg syndrome, which is a neurological disorder characterized by uncomfortable sensation of paraesthesia in legs that subsequently causes involuntary and continuous movement of the lower limbs especially in night which can lead to; sleep disorder, anxiety, fatigue, depression, disturbance of ability to work and social isolation. Moderate exercise may be helpful in relieving restless leg syndrome. The aim of the study is to assess the effect of muscles stretching exercises on severity of restless legs syndrome of adult patients undergoing hemodialysis. A quasi-experimental design was utilized. Sample: 40 convenience adult patients diagnosed with renal failure and undergoing hemodialysis. Settings; Hemodialysis department in the Students Hospital Affiliated to Tanta University and Elmabra Hospital for Health Insurance. Data collection: Structured interview used to elicit data which comprises two tools; Tool 1: Health assessment tool which include Bio-Socio-demographic characteristics data; Tool 2: International Restless Legs Syndrome Rating Scale (IRLSRS). Data was collected through three phases; Assessment, implementation and evaluation phase through 20 weeks. Results: Indicated improvement of severity of restless leg syndrome symptoms of the study group post comparing to pre muscle stretching exercise. Conclusion: muscles stretching exercise plays an important role in reducing the severity of RLS symptoms of adult patients undergoing hemodialysis. Recommendation: Nurses has to be encouraged to help alleviate the severity of RLS symptoms by training muscle stretching exercises to the patients undergoing heamodialysis.

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Section: Discussioncontrasting

confidence: 92%

Section: Discussionmentioning

confidence: 88%

Effect of Muscles Stretching Exercises on Severity of Restless Legs Syndrome of Adult Patients Undergoing Hemodialysis

2019

JHMN

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“…Previous studies showed that RLS occurred in 12% to 62% of dialysis patients [6][7][8][9], and higher incidence rates of RLS among dialysis patients have been reported in studies outside Japan. This may be attributable to the fact that for dialysis therapy in Japan, ultra-pure dialysis fluids and highor super high-flux dialyzers with excellent biocompatibility are frequently used, which ensure the quality of dialysis to be satisfactory.…”

Section: Discussionmentioning

confidence: 92%

Therapeutic effect of high-efficiency online hemodiafiltration for recurrent restless legs syndrome in dialysis patients

et al. 2020

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Two dialysis patients developed recurrent restless legs syndrome. The clinical courses and the association between the α 1microglobulin removal rate and the therapeutic effects of hemodiafiltration were analyzed. Case 1: a middle-aged woman was switched from predilution online hemodiafiltration to hemodialysis, following which the α 1-microglobulin removal rate decreased from 39.1 to 29.9%. A month later, the severe restless legs syndrome occurred. The treatment was then switched to high-efficiency hemodiafiltration and 2 weeks later, these symptoms were resolved. The α 1-microglobulin removal rate increased to 41.9%. Her symptoms recurred 5 years later with severity; thus, the hemodiafiltration treatment conditions were changed. Under revised conditions, the α 1-microglobulin removal rate was 42.6%, and her symptoms were alleviated. Continuation of high-efficiency hemodiafiltration led to the resolution of the syndrome at 1 month after recurrence. Case 2: a middle-aged man on hemodialysis developed the restless legs syndrome in the second year of treatment. The α 1-microglobulin removal rate was 23.8%. After switching to a month-long high-efficiency hemodiafiltration with a removal rate of ≥ 40%, his symptoms were resolved. However, the syndrome recurred after a year with severity. The symptoms were alleviated using various measures. The hemodiafilters were changed, and hemodiafiltration with an α 1-microglobulin removal rate of ≥ 40% was continued; 2 months later, his symptoms resolved. High-efficiency online hemodiafiltration is an effective therapeutic strategy for restless legs syndrome in dialysis patients. We found, for the first time, that target removal efficiency is an α 1microglobulin removal rate of 40% or higher.

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“…Caffeine, alcohol, antidepressants other than bupropion, antipsychotics, antiemetics, dopamine blockers, are centrally acting antihistamines. However, other studies show that cigarette smoking and coffee drinking is not related to RLS causes [ 16 ].…”

Section: Reviewmentioning

confidence: 99%

Restless Leg Syndrome in the Setting of Patients With End-Stage Renal Disease on Hemodialysis: A Literature Review

Kambampati¹,

Wasim²,

Kukkar³

et al. 2020

Cureus

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Restless Leg Syndrome (RLS), or Willis-Ekbom disease (WED), is an irresistible urge to move the legs, predominantly while resting, sitting, or sleeping, which disrupts sleep and impairs quality of life. RLS can occur secondary to uremia in chronic kidney disease (CKD) patients due to inadequate hemodialysis. Early diagnosis is essential to prevent muscular atrophy and to improve the quality of life of RLS patients, especially those with end-stage renal disease (ESRD). Cardiac mortality high in uremic RLS patients due to associated discomfort and lowering the duration of hemodialysis treatment. This review focuses on and discusses the diagnosis, treatment, and associated comorbid conditions of uremic RLS. Though the exact pathophysiology is unknown, altered transferrin expression in the choroid plexus, increased glutamate levels in the thalamus, decreased opioid receptors, dopamine system dysfunction, calcium/phosphate imbalance, and single nucleotide polymorphisms in the BTBD9 and MEIS1 genes are a few nonconfirmatory pathophysiological concepts for uremic RLS. Nonpharmacological options include lowering the temperature of dialysate by 1 degree C and home-based therapies like massages, warm/cold baths, and aerobic exercises. Pharmacological therapy like dopamine agonists ropinirole and pramipexole reduces the symptoms effectively. However, surgical options like parathyroidectomy and renal transplantation are stated as the best treatment options in patients suffering from uremic RLS.

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Restless legs syndrome in end stage renal disease patients undergoing hemodialysis

Cited by 36 publications

References 42 publications

Effect of Muscles Stretching Exercises on Severity of Restless Legs Syndrome of Adult Patients Undergoing Hemodialysis

Effect of Muscles Stretching Exercises on Severity of Restless Legs Syndrome of Adult Patients Undergoing Hemodialysis

Therapeutic effect of high-efficiency online hemodiafiltration for recurrent restless legs syndrome in dialysis patients

Restless Leg Syndrome in the Setting of Patients With End-Stage Renal Disease on Hemodialysis: A Literature Review

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