Restless Legs Syndrome in Hemodialysis Patients: Association with Calcium Antagonists

Telarović, Srđana; Relja, Maja; Trkulja, Vladimir

doi:10.1159/000104718

Cited by 18 publications

(12 citation statements)

References 35 publications

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“…Heterogeneity is also present in the studies that investigated RLS prevalence in patients with MS, which could explain diff erences in the estimated prevalence among the studies 11 . Pooled analysis performed in the meta-analysis by Schürsk and Bussfeld 11 indicates that MS is associated with a fourfold increase in the odds for RLS compared with people without MS. Th is is in concordance with our survey, since the estimated prevalence of the idiopathic form of RLS in Croatia is 9.5% 16 .…”

Section: Discussionsupporting

confidence: 92%

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Restless Legs Syndrome In Multiple Sclerosis Patients – Patient Experience Atlipik Special Hospital For Medical Rehabilitation

Rovazdi¹

2017

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SUMMARY -Th e study included 60 patients with multiple sclerosis (MS) hospitalized at our institution from September 1 to December 31, 2014. Th e aim of the study was to assess the prevalence of restless legs syndrome (RLS) in MS patients and RLS relationship with patient age, sex, degree of disability, form of MS, time elapsed from MS diagnosis and use of antidepressants. Th e diagnosis of RLS was made according to the criteria set by the International Restless Legs Syndrome Study Group. Of the 60 patients, 24 (40%) met the criteria for the existence of RLS. In the group of patients with RLS, there was a signifi cantly higher proportion of women and those that were taking antidepressants. Th ere were no statistically signifi cant between-group diff erences according to age, duration of illness, degree of disability and clinical course of MS. In the study, 37.5% of patients that met the criteria for RLS diagnosis had not informed the neurologists about their diffi culties. Th e high prevalence of RLS and the fact that a large proportion of patients did not inform the neurologists about their diffi culties related to RLS point to the need of an active approach to diagnosis and treatment.

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Section: Discussionsupporting

confidence: 92%

“…Although the true reason for this is not known, cervical cord damage was found to be associated with a higher prevalence of RLS in MS patients 15 . Th e prevalence of idiopathic RLS in Croatia is 9.5% 16 . In this study, we investigated RLS prevalence in MS patients.…”

Section: Introductionmentioning

confidence: 99%

Restless Legs Syndrome In Multiple Sclerosis Patients – Patient Experience Atlipik Special Hospital For Medical Rehabilitation

Rovazdi¹

2017

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“…Three studies had provided evidence that longer history of dialysis was a risk factor of RLS. 28,33,34 One suggested that RLS was caused by the accumulation of a middle molecule in dialysis-related amyloid, which was similar to the accumulation of b 2 -microglobulin. 11 However, longer duration of dialysis was reported not to affect the risk in another three studies.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of restless legs syndrome in chronic kidney disease: a systematic review and meta-analysis of observational studies

et al. 2016

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Introduction: Nowadays prevalence of restless legs syndrome (RLS) in chronic kidney disease (CKD) patients was reported in many studies, while the results varied. The aim of our study was to investigate the prevalence of RLS in this population, considering different data collecting measures and diagnostic criteria. Methods: MEDLINE, Embase, PsycINFO, and Scopus databases were searched for relevant studies. We limited the analyses to studies using clinical interview or questionnaire for diagnosis. Univariate meta-regression analysis was preformed to assess the effects of the disease-related covariates on prevalence estimates. Comprehensive Meta-Analysis 2.0 was used to perform the meta-analysis. Results: Fifty-one studies were included in the analysis. Prevalence of RLS was varied by renal function and diagnostic methods. Overall prevalence in CKD populations was 24.2% (95%CI, 20.1-28.7). Pooled prevalence of RLS was higher in patients diagnosed by questionnaire than by clinical interview [26.2% (95%CI, 17.9-36.5) vs. 23.6% (95%CI, 19.6-28.1)]. When grouped by CKD setting, the prevalence was 28.4% (95%CI, 24.6-32.6) in dialysis patients, followed by early stages patients [9.9% (95%CI, 5.4-17.5)], and kidney transplant recipients [6.7% (95%CI, 5.6-7.8)]. Conclusions: Our meta-analysis suggested that more than one-quarter of CKD sufferers, especially those who were on dialysis, were plagued by RLS. Higher sensitivity of diagnostic criteria in interview may be valuable for timely treatment.

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“…Ayrıca yaşla birlikte sıklığı artmaktadır. Yapılan çalışmalarda HD hastalarında HBS sıklığı, Amerika'da (%20,8), Hırvatistan'da (%60) olarak saptanmıştır [20,21]. Türkiye'de Çölbay ve arkadaşlarının yaptığı 95 hemodiyaliz hastasının alındığı çalışmada HBS sıklığı %45,3 oranda (43 hastada) tespit edilmiştir.…”

Section: Discussionunclassified

“…HD hastalarında ise yaşın HBS gelişimi açısından bir risk faktörü olmadığına dair yayınlar bulunmaktadır [21]. Dikkat edilmesi gereken konulardan biri de diyaliz hastalarında başta üremik nöropati, periferik vasküler hastalıklar ve diabetik nöropati olmak üzere HBS ile karışabilecek pek çok sorunun beraber bulunmasıdır.…”

Section: Discussionunclassified

Hemodiyaliz hastalarında uyku kalite bozukluğu ve huzursuz bacak sendromu arasındaki ilişki

Hüzmelí¹,

Candan²,

Koçkara³

et al. 2014

Cumhuriyet Med J

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Amaç. Huzursuz bacak sendromu (HBS) bacaklarda huzursuzluk hissi, yanma ile kendini gösteren istirahat ve geceleri daha sık olan bacakları hareket ettirme isteği ile karakterize bir rahatsızlıktır. Bu durum hemodiyaliz hastalarında sıktır ve uykusuzluğa neden olabilir. Biz çalışmamızda uyku kalitesinde bozukluk ile HBS arasındaki ilişkiyi incelemeyi amaçladık. Yöntem. Çalışmaya hemodiyaliz programında olan hastalar alındı. Hastalara Uluslar arası huzursuz bacak çalışma grubu tanı kriterleri kullanıldı ve uyku kalitesi bozukluğu için Pittsburg uyku kalitesi indeksi kullanıldı. Hastaların tümünde hemogram, PTH, kalsiyum, fosfor, kreatinin, demir, serum demir bağlama kapasitesi ve ferritin değerleri değerlendirildi. Bulgular. Çalışmaya 112 hemodiyaliz hastası alındı. Hastaların yaş ortalaması 56,8 ± 16,2 idi. Hastaların %61,6'sında uyku kalitesinde bozukluk ve %66,1'inde HBS tespit edildi. Uyku kalite bozukluğu ile HBS arasında anlamlı bir ilişki (p<0.05) saptandı. Uyku kalitesinde bozukluk ve HBS'nun anemi, PTH, kalsiyum ve fosfor değerleriyle anlamlı bir ilişkisi saptanmadı. Sonuç. Çalışmamızda uyku kalitesinde bozukluk ile HBS arasında anlamlı bir ilişki saptandı. Hemodiyaliz hastalarında uyku kaliteside bozukluk ve HBS sık olmasına rağmen etyolojisi net bilinmemektedir. HBS semptomlarının gece daha sık olmasından dolayı uyku kalitesinin bozukluklarına neden olabileceği düşünülmektedir.Anahtar sözcükler: Huzursuz bacak sendromu, uyku kalitesinde bozukluk, hemodiyaliz Abstract Aim. Restless legs syndrome (RLS) an ilness characterized by discomfort in the legs, rest manifested by burning and a desire to move the legs more often at night. This situation is common in hemodialysis patients and can cause insomnia. In our study, we aimed to investigate the relationship between the RLS and quality of sleep disorders. Methods. The study enrolled patients who were receiving hemodialysis. The international restless legs study group criteria were used for patients and the Pittsburg sleep quality index was used for sleep disturbance. In all patients, complete blood count, PTH, calcium, phosphorus, creatinine, iron, serum iron binding capacity and ferritin levels were evaluated. Results. The study enrolled 112 hemodialysis patients. The mean age of patients was 56.8 ± 16.2. In patients 61.6% the disorder in sleep quality was detected and in 66.1% the RLS was detected. A significant relationship between quality of sleep disorders and RLS (p<0.05) were detected. A significant association among disorders in sleep quality and RLS anemia, PTH, calcium and phosphorus levels were not detected. Conclusion. In our study, a significant relationship between quality of sleep disorders and RLS was detected. In hemodialysis patients, disorders in sleep quality and RLS is more common, but its etiology is unclear. Due to RLS symptoms more often at the night it is thought to be lead to quality of sleep disorders.

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Restless Legs Syndrome in Hemodialysis Patients: Association with Calcium Antagonists

Cited by 18 publications

References 35 publications

Restless Legs Syndrome In Multiple Sclerosis Patients – Patient Experience Atlipik Special Hospital For Medical Rehabilitation

Restless Legs Syndrome In Multiple Sclerosis Patients – Patient Experience Atlipik Special Hospital For Medical Rehabilitation

Prevalence of restless legs syndrome in chronic kidney disease: a systematic review and meta-analysis of observational studies

Hemodiyaliz hastalarında uyku kalite bozukluğu ve huzursuz bacak sendromu arasındaki ilişki

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