Restless legs syndrome in migraine patients: prevalence and severity

Oosterhout, Willebrordus P J van; Someren, Eus J.W. Van; Louter, Mark A.; Schoonman, Guus; Lammers, Gert Jan; Rijsman, Roselyne M.; Ferrari, Michel D.; Terwindt, Gisela M.

doi:10.1111/ene.12993

Cited by 29 publications

(31 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[57][58][59][60] Migraine is also associated with more severe symptoms of RLS. 61 These replicated findings of RLS with migraine may be reflected in the PSG observations of decreases in sleep efficiency or in the subjective complaints of difficulty initiating sleep. Pathophysiologically, this association brings attention to the role of dopamine in both migraine and RLS.…”

Section: Sleep Disorders and Their Relationship To Migrainementioning

confidence: 75%

Sleep Disorders and Migraine: Review of Literature and Potential Pathophysiology Mechanisms

2018

View full text Add to dashboard Cite

Migraine shares a complex and poorly understood relationship with sleep. Patients consistently report poor sleep prior to migraine attacks and during them, identifying poor sleep as a migraine trigger. However, anecdotally, sleep is reported to serve a therapeutic role in terminating headache. Are the associations between migraine and sleep simply the result of various bidirectional relationships? A growing body of evidence suggests there may be a common underlying etiology as well. Our objective was to review studies of sleep and migraine from the last 2 decades utilizing validated subjective and objective measures of sleep and to explore potential mechanisms underlying this complex relationship by incorporating recent advances in neuroscience. We specifically focus on insomnia, obstructive sleep apnea, parasomnias, sleep related movement disorders, and REM sleep related disorders and their relationship to migraine. Parts of brainstem-cortical networks involved in sleep physiology are unintentionally being identified as important factors in the common migraine pathway. Recent discoveries on anatomic localization (the hypothalamus as a key and early mediator in the pathophysiology of migraine), common mediating signaling molecules (such as serotonin and dopamine), and the discovery of a new CNS waste removal system, the glymphatic system, all point to a common pathophysiology manifesting in migraine and sleep problems.

show abstract

Section: Sleep Disorders and Their Relationship To Migrainementioning

confidence: 75%

Sleep Disorders and Migraine: Review of Literature and Potential Pathophysiology Mechanisms

2018

View full text Add to dashboard Cite

show abstract

“…A good example of such interplay is migraine: a neurologic disease with disturbed vascular function and processing of sensory/painful stimuli. Prevalence of RLS/PLMS is higher in subjects with migraine (both adults and children) what suggests a link between the presence of PLMS and disordered control over vascular and sensory processes [15, 16]. …”

Section: Discussionmentioning

confidence: 99%

Periodic limb movements in sleep are followed by increases in EEG activity, blood pressure, and heart rate during sleep

Siemiński

Pyrzowski

Partinen³

2017

Sleep Breath

View full text Add to dashboard Cite

PurposePeriodic limb movements in sleep (PLMS) are related to arousal, sympathetic activation, and increases in blood pressure (BP), but whether they are part of the arousal process or causative of it is unclear. Our objective was to assess the temporal distribution of arousal-related measures around PLMS.MethodsPolysomnographic recordings of six patients with restless legs syndrome were analyzed. We analyzed 15 PLMS, plus three 5-s epochs before and after each movement, for every patient. Mean values per epoch of blood pressure (BP), heart rate (HR), and electroencephalographic (EEG) power were calculated. For each patient, six 5-s epochs of undisturbed sleep were analyzed as controls.ResultsAlpha + beta EEG power, systolic BP, and HR were significantly increased following PLMS. The EEG power and HR increases were noticed in the first epoch after PLMS, whereas that of systolic BP was observed in the second and third epochs following a PLMS. No significant changes occurred in the epochs of undisturbed sleep.ConclusionsThe results suggest that PLMS are followed by arousal-related nervous system events. Given the high frequency of PLMS throughout the night, they could be a potential risk factor for nocturnal arrhythmias and hypertension, in addition to causing sleep deprivation.

show abstract

“…More recently, a large population-based study that collected data from approximately 2300 patients has indicated that RLS is more prevalent and more severe in patients with migraine, and is also associated with poorer sleep quality. However, conditions mimicking RLS could not be excluded, which may have influenced the results [ 38 , 39 ]. The results of the present study, consistent with those of previous studies [ 7 , 8 , 36 – 39 ], indicate that migraineurs have a higher prevalence of RLS than controls.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of restless legs syndrome in migraine patients with and without aura: a cross-sectional, case-controlled study

Lin

Lee

et al. 2016

J Headache Pain

View full text Add to dashboard Cite

BackgroundAlthough the comorbidity of migraine and restless legs syndrome (RLS) has been well-documented, the association between RLS and migraine frequency has yet to be elucidated. The present study aims to evaluate the prevalence of RLS among individuals who experience low-frequency, high-frequency, or chronic migraine presenting with and without aura.MethodsWe conducted a cross-sectional, case-controlled study involving 505 participants receiving outpatient headache treatment. Standardized questionnaires were administered to collect information on experiences of migraine, RLS, sleep quality, anxiety, depression, and demographics. Participants were categorized into low-frequency (1–8/month), high-frequency (9–14/month), and chronic (≥15/month) headache groups. RLS was diagnosed according to the criteria outlined by the International RLS Study Group (IRLSSG). The Pittsburgh Sleep Quality Index (PSQI) and Hospital Anxiety and Depression Scale (HADS) were used to assess sleep quality and identify symptoms of anxiety and depression. Associations between migraine frequency and RLS prevalence were investigated using multivariate linear and logistic regression.ResultsUnivariate analysis revealed an effect of migraine frequency on RLS prevalence (p = 0.026), though this effect did not persist following adjustment for baseline characteristics (p = 0.256). The trend was robust in patients whose migraines presented with auras (p univariate = 0.002; p multivariate = 0.043) but not in those without auras (p univariate and p multivariate > 0.05). Higher anxiety [odds ratio (OR) = 1.18, p = 0.019] and sleep disturbance (OR = 1.17, p = 0.023) scores were associated with higher RLS prevalence.ConclusionsHigher migraine frequency correlates with a higher prevalence of RLS, particularly among patients with auras.

show abstract

Restless legs syndrome in migraine patients: prevalence and severity

Abstract: Restless legs syndrome is not only twice as prevalent but also more severe in migraine patients, and associated with decreased sleep quality.

Cited by 29 publications

References 39 publications

Sleep Disorders and Migraine: Review of Literature and Potential Pathophysiology Mechanisms

Sleep Disorders and Migraine: Review of Literature and Potential Pathophysiology Mechanisms

Periodic limb movements in sleep are followed by increases in EEG activity, blood pressure, and heart rate during sleep

Prevalence of restless legs syndrome in migraine patients with and without aura: a cross-sectional, case-controlled study

Contact Info

Product

Resources

About