Restless legs syndrome is associated with headache‐related disabilities in patients with migraine: a prospective 7‐year follow‐up study

Suzuki, Keisuke; Suzuki, Shigeaki; Haruyama, Yasuo; Kobashi, Gén; Shiina, Tomohiko; Hirata, Koichi

doi:10.1111/ene.13796

Cited by 13 publications

(10 citation statements)

References 41 publications

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“…In recent years, widespread attention has been paid to the comorbid association between migraine and RLS. This study found that the prevalence of RLS in migraine patients (22.29%) was significantly higher than that in non-headache controls (6.62%), which was consistent with other research findings ( 3 , 6 , 21 , 23 , 24 ). In addition, it has also been found that migraines and RLS affect each other.…”

Section: Discussionsupporting

confidence: 93%

“…Univariate analysis revealed that the monthly days with headache, high PSQI score, high HADS score, and vitamin D deficiency were the risk factors for RLS in patients with migraines. Firstly, in terms of sleep quality, anxiety, and depression, a large number of previous studies have reported that migraine patients complicated with RLS have worse sleep quality and more significant anxiety and depression symptoms than those with migraine alone ( 3 , 7 , 21 , 23 , 24 ). Besides, these clinical factors are related to the occurrence of RLS ( 3 , 7 , 21 ), consistent with our findings.…”

Section: Discussionmentioning

confidence: 99%

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Association Between Migraine Complicated With Restless Legs Syndrome and Vitamin D

et al. 2021

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Background: This study aimed to evaluate the prevalence of restless legs syndrome (RLS) in patients with migraine and explore its association with vitamin D deficiency, aiming to provide biological support for the comorbidity of migraine with RLS, and shed new lights into clinical diagnosis and treatment.Methods: A case-control study was performed on 175 migraine patients and 151 non-headache controls. The information of all subjects concerning headache severity [visual analog scale (VAS) score], RLS, RLS severity [International Restless Legs Scale (IRLS) score], sleep quality [Pittsburgh sleep quality index (PSQI)], anxiety and depression symptoms [hospital anxiety and depression scale (HADS)], and demographic data were collected. At the same time, serum 25-(OH) D levels were also measured (concentration <20 ng/ml was defined deficiency). Afterward, the logistic regression model was adopted to explore the risk factors for RLS in patients with migraines.Results: Compared with control group, migraine group had lower vitamin D levels [(21.10 ± 6.58) vs. (16.42 ± 5.6) ng/ml, P < 0.001], a higher rate of vitamin D deficiency (45.03 vs. 72%, P <0001), higher prevalence of RLS (6.62 vs. 22.29%, P < 0.001). Compared with the pure RLS group, RLS with the migraine group had lower vitamin D levels and higher IRLS score (P < 0.05). Compared with pure migraine group, migraine with RLS group had lower vitamin D levels [(17.36 ± 5.56) vs. (13.15 ± 4.42) ng/ml, P < 0.001], higher incidence of vitamin D deficiency (66.18 vs. 92.31%, P = 0.001), higher frequency of headache attacks (P = 0.004). Thereafter, the multivariate logistic regression model was employed to adjust confounding factors such as age, gender, season, frequency of headache attacks, PSQI score, and HADS scores. According to the results vitamin D deficiency in patients with migraines was an independent risk factor for RLS (OR = 5.03, 95%CI: 1.2–21.16, P = 0.027).Conclusions: The prevalence of RLS in migraine patients was significantly higher than that in the non-headache population. Besides, vitamin D levels decreased, while the incidence of vitamin D deficiency increased in the migraine patients complicated with RLS. Finally, the occurrence of RLS in migraine patients was significantly related to vitamin D deficiency.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Association Between Migraine Complicated With Restless Legs Syndrome and Vitamin D

et al. 2021

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“… 52 The presence of RLS also predicted headache-related disability in migraine patients 7 years later. 77 Although not yet proven, the management of sleep disturbances in migraine, especially RLS, may improve CS in migraine.…”

Section: Methodsmentioning

confidence: 99%

Central Sensitization in Migraine: A Narrative Review

Suzuki¹,

Suzuki²,

Shiina³

et al. 2022

JPR

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Central sensitization (CS) is an increase in the responsiveness of nociceptive neurons in the central nervous system to their normal afferent input. As a result, even minor irritation can induce severe pain, leading to the chronicity and severity of various diseases, such as neurological disorders. CS is associated with migraine, which is a major neurological disorder that inflicts a high disability in daily life. Specifically, CS is thought to be involved in the pathogenesis of cutaneous allodynia as well as chronification of migraine. In this article, we reviewed the association between CS and migraine, including pathophysiological aspects and evidence from clinical studies. We suggest that appropriate screening and management of CS in migraine could further improve the quality of life of migraine patients.

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“…Nu sta ty ta, kad di des nis NKS pa pli ti mas yra su si jaes su daþnes niu mig re nos su au ra pa si reið ki mu [8]. Ki tø ty ri mø rezul ta tai pa ro dë, kad NKS simp to mai yra stip res ni ser gantiems mig re na, o ðiø li gø ko mor bi dið ku mas le mia sun kesnae pa cien tø bûk lae [11,35]. Re mian tis li te ra tû ros duo me nimis, ga li ma teig ti, kad mig re na ir NKS ga li ska tin ti vie nas ki to pa si reið ki mà [3,4,11].…”

Section: Paplitimasunclassified

“…Do pa mi nas taip pat da ly vau ja mig re nos pa to fi zio lo gijo je. At lik tuo se ty ri muo se nu sta ty ta, kad ser gan tie ji mig rena yra jaut res ni do pa mi ner gi niams vais tams ir, pa si reið kus mig re nai, ma to mas at virkð ti nis do pa mi no an ta go nis tø povei kis [35,38]. Ma no ma, kad NKS ir mig re na yra su si jae su A11 do pa mi ner gi niu bran duo liu, esan èiu po gum bu ry je (pav.).…”

Section: Patofiziologijaunclassified

Migraine and restless legs syndrome – is there an association?

Bučaitė,

Normantas,

Žemgulytė

2023

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Migraine and restless legs syndrome are diseases that disturb the normal quality of human life. Moreover, comorbidity of these disorders determines even more difficult condition of the patients. Migraine is a headache that can cause severe throbbing pain, usually on one side of the head, and it is often accompanied by nausea, vomiting, and extreme sensitivity to light and sound. Migraine is one of the reasons that can cause unhealthy sleep, and if sleep is disturbed, this leads to the provocation of migraine attacks. Sleep disorders have various clinical manifestations, one of which is restless legs syndrome. It is a neurosensory impairment which is characterized by an unrelenting urge to move the legs that occurs or worsens at rest. For this reason, patients may complain of impaired sleep. Although the relationship between migraine and restless legs syndrome and their pathogenesis is not fully understood, current research suggests that these diseases may be related. People with restless legs syndrome are 1.23 to 2.65 times more likely to develop migraine attacks. It is believed that the occurrence of both diseases is determined by several pathophysiological factors, such as the activity of the dopamin- ergic system, iron deficiency, genetic predisposition, and changes in the gray matter of the brain. Although the association between restless legs syndrome and migraine is being investigated, the predominant pathophysiological link has not yet been established. Separate treatment of these diseases has been known for a long time. The principle of migraine treatment is to suppress pain and reduce the frequency of attacks. Treatment for restless legs syndrome is based on the relief of symptoms. Unfortunately, a common treatment for both diseases in relation to each other has not yet been approved. Because of the similar pathophysiology of these disorders, drugs that affect the dopaminergic system (e.g., pramipexole) are currently being investigated in order to relieve the symptoms of restless legs syndrome and migraine attacks.

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Restless legs syndrome is associated with headache‐related disabilities in patients with migraine: a prospective 7‐year follow‐up study

Abstract: Our prospective study showed that RLS had a significant impact on headache-related disability in patients with migraine.

Cited by 13 publications

References 41 publications

Association Between Migraine Complicated With Restless Legs Syndrome and Vitamin D

Association Between Migraine Complicated With Restless Legs Syndrome and Vitamin D

Central Sensitization in Migraine: A Narrative Review

Migraine and restless legs syndrome – is there an association?

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