Restless Legs Syndrome: Prevalence and Impact in Children and Adolescents—The Peds REST Study

Picchietti, Daniel L.; Allen, Richard P.; Walters, Arthur S.; Davidson, Julie; Myers, Andrew; Ferini‐Strambi, Luigi

doi:10.1542/peds.2006-2767

Cited by 360 publications

(249 citation statements)

References 54 publications

Supporting

Mentioning

214

Contrasting

Unclassified

Order By: Relevance

“…Three prior large epidemiological studies used an expert consensus definition of clinically significant RLS ("RLS sufferers") as symptoms occurring at least twice weekly with moderate to severe distress [12][13][14]. The CH-RLSq13 included these frequency and distress items to define RLS severity allowing comparison of results.…”

Section: Methodsmentioning

confidence: 99%

The prevalence and impact of restless legs syndrome on patients with iron deficiency anemia

et al. 2013

Self Cite

View full text Add to dashboard Cite

Restless Legs Syndrome (RLS) a common, under-recognized disorder disrupts sleep and diminishes quality of life. Despite a clear relation between low peripheral iron and increased prevalence and severity of RLS, the prevalence and clinical significance of RLS in iron-deficient anemic (IDA) populations is unknown. In this study all new patients referred for anemia to a community-based hematology practice over a 1-year period (March 2011(March -2012 were included if they had IDA and no RLS treatment. Patients completed a validated questionnaire identifying RLS, blood tests, and a sleep-vitality questionnaire (SVQ). Patients with RLS were compared to patients with no RLS for differences on SVQ, blood tests, baseline characteristics, and sleep quality. Three hundred forty-three patients were evaluated and 251 (89.2% female, average age of 45.6 years) included in the study. The prevalence of clinically significant RLS (RLS sufferers) was 23.9%, nine times higher than the general population. IDA-RLS sufferers reported poorer quality of sleep, decreased sleep time, increased tiredness, and decreased energy during the day compared to patients with IDA without RLS. Blood tests did not relate to RLS diagnosis but RLS was less likely for African-American than Caucasian patients. Clinically significant RLS occurs commonly with IDA producing much greater disruption of sleep and shorter sleep times than does IDA alone. This indicates the need for identification of RLS with IDA and consideration of appropriate therapeutic interventions for this sizeable subgroup: either aggressive iron treatment to reduce the RLS symptoms or medications for RLS or both. Am. J. Hematol. 88:261-264, 2013. V C 2013 Wiley Periodicals, Inc. IntroductionIron deficient anemia (IDA) occurs commonly particularly among American women of child-bearing age [1] The Willis-Ekbom Disease, better known as the restless legs syndrome (RLS) is exacerbated and engendered by reduced peripheral iron stores and therefore should be both common and moderately severe in IDA. RLS is well-defined but commonly over-looked cause of significant morbidity with established relationships to genetics [2] and iron biology [3]. Moderately severe to severe RLS is a major health problem [4] producing periods of torturous restlessness during sleep often reducing sleep times to 5 hr or less [5]. Presumably RLS occurring with IDA if not adequately treated will have the same adverse health effects, but this has not been previously studied.The only two prior studies of RLS in patients with IDA reported a very high RLS prevalence of about 40% [6,7]. These studies used small, academic-hospital-based populations with limited, nonvalidated, nonstandardized criteria to make the diagnosis. The accuracy of these prevalence estimates is therefore questionable. More significantly, the severity of RLS was not reported. RLS has a broad range of severity from a rarely occurring mild annoyance to a clinically significant disease severely impairing sleep, quality of life, health, and ability to work...

show abstract

Section: Methodsmentioning

confidence: 99%

The prevalence and impact of restless legs syndrome on patients with iron deficiency anemia

et al. 2013

Self Cite

View full text Add to dashboard Cite

show abstract

“…One study indicated that 71% of the children having RLS symptoms had at least one biological parent with RLS. 14 As in the adult population, in samples of children and adolescents, RLS symptoms were associated with sleep disturbances including sleep onset or sleep maintenance insomnia. 14 To our knowledge, there are no extant studies that have investigated the presence of RLS in biological caregivers of children with ASD or the relationships of these symptoms to caregiver HRQoL.…”

Section: Introductionmentioning

confidence: 92%

Symptoms of Restless Legs Syndrome in Biological Caregivers of Children with Autism Spectrum Disorders

Russell

Baldwin

McClain

et al. 2017

Journal of Clinical Sleep Medicine

View full text Add to dashboard Cite

Study Objectives: In this study, we investigated the prevalence of symptoms of restless legs syndrome (RLS) in biological caregivers of children with a diagnosis of autism spectrum disorder (ASD).The relationship of RLS symptoms to caregiver health-related quality of life (HRQoL) was also examined. Finally, we compared the sleep quality and daytime behaviors of children with ASD in caregivers with and without symptoms of RLS. Methods: Biological caregivers (n = 50) of children ages 6 to 11 y with a diagnosis of ASD completed a Sleep Habits Questionnaire (SHQ) that included RLS as determined by four questions. HRQoL was assessed using the Medical Outcomes Survey (MOS) 12-Item Short Form (SF-12). Caregivers also completed the Children's Sleep Habits Questionnaire (CSHQ) and Child Behavior Checklist (CBCL6/18). Results: Eleven caregivers (22%) fit the criteria for RLS symptomatology and caregivers with RLS reported poorer mental health. Caregivers with RLS described more night waking and greater internalized behavior problems in their children with ASD than the caregivers without RLS. Conclusions: Biological caregivers of children with ASD demonstrated a high prevalence of RLS symptoms and poorer mental health. RLS is known as a sleep disorder that has strong heritability, and it is possible that many of the children with ASD also have symptoms of RLS. RLS as a possible disruptor of sleep should be considered in caregivers and in their children with ASD. Keywords: autism spectrum disorder, caregivers, health-related quality of life, restless legs syndrome Citation: Russell M, Baldwin C, McClain D, Matthews N, Smith C, Quan SF. Symptoms of restless legs syndrome in biological caregivers of children with autism spectrum disorders.

show abstract

“…Two studies on the prevalence of RLS performed in children found rates of 31.7% and 5.9% respectively 124,125 . The study by Laberge and colleagues 125 in Canada, assessed the prevalence and interactions between certain sleep disorders.…”

Section: Epidemiologymentioning

confidence: 99%

“…In 2007, Picchietti and colleagues 124 conducted a study to assess the prevalence of RLS in children, using the criteria of IRLSSG. A prevalence of 1.9% of children between 8 and 11 years old, and 2.0% of children between 12 and 17 years old.…”

Section: Epidemiologymentioning

confidence: 99%

Brazilian consensus on guidelines for diagnosis and treatment for restless legs syndrome

Fröhlich

Éckeli

Bacelar³

et al. 2015

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

show abstract

Restless Legs Syndrome: Prevalence and Impact in Children and Adolescents—The Peds REST Study

Abstract: These population-based data suggest that restless legs syndrome is prevalent and troublesome in children and adolescents, occurring more commonly than epilepsy or diabetes.

Cited by 360 publications

References 54 publications

The prevalence and impact of restless legs syndrome on patients with iron deficiency anemia

The prevalence and impact of restless legs syndrome on patients with iron deficiency anemia

Symptoms of Restless Legs Syndrome in Biological Caregivers of Children with Autism Spectrum Disorders

Brazilian consensus on guidelines for diagnosis and treatment for restless legs syndrome

Contact Info

Product

Resources

About