Restoration of a large osteochondral defect of the knee using a composite of umbilical cord blood-derived mesenchymal stem cells and hyaluronic acid hydrogel: a case report with a 5-year follow-up

Park, Yong Bum; Ha, Chul‐Won; Lee, Choong-Hee

doi:10.1186/s12891-017-1422-7

Cited by 25 publications

(14 citation statements)

References 51 publications

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“…Furthermore, UCMSCs have been directly compared to TMJ condyle chondrocytes in vitro and significantly outperform the differentiated chondrocytes in GAG and collagen sythesis and proliferation when seeded on a PGA scaffold [152] . Bone regeneration at the osteochondral interface are primary targets for UCMSCs due to their regenerative capacity; however, these cells have yet to be used in scaffolds implanted into a TMJ condyle [153,154] .…”

Section: -2-1 Stem Cells-mentioning

confidence: 99%

Tissue Engineering for the Temporomandibular Joint

Acri

Shin

Seol

et al. 2018

Adv Healthcare Materials

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Tissue engineering potentially offers new treatments for disorders of the temporomandibular joint which frequently afflict patients. Damage or disease in this area adversely affects masticatory function and speaking, reducing patients' quality of life. Effective treatment options for patients suffering from severe temporomandibular joint disorders are in high demand because surgical options are restricted to removal of damaged tissue or complete replacement of the joint with prosthetics. Tissue engineering approaches for the temporomandibular joint are a promising alternative to the limited clinical treatment options. However, tissue engineering is still a developing field and only in its formative years for the temporomandibular joint. This review outlines the anatomical and physiological characteristics of the temporomandibular joint, clinical management of temporomandibular joint disorder, and current perspectives in the tissue engineering approach for the temporomandibular joint disorder. The tissue engineering perspectives have been categorized according to the primary structures of the temporomandibular joint: the disc, the mandibular condyle, and the glenoid fossa. In each section, contemporary approaches in cellularization, growth factor selection, and scaffold fabrication strategies are reviewed in detail along with their achievements and challenges.

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Section: -2-1 Stem Cells-mentioning

confidence: 99%

Tissue Engineering for the Temporomandibular Joint

Acri

Shin

Seol

et al. 2018

Adv Healthcare Materials

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“…In the present study, we have evaluated the efficacy of bone marrow- Articular cartilage (AC) is an extremely specialized, avascular, and aneural connective tissue with minimum self-healing ability that may lead to progressive damage and joint deterioration even with minor lesions or injuries (Liu et al, 2017;Park et al, 2017;Perera et al, 2012 (Zheng et al, 2017), bone, cartilage, tendon regeneration (Im, 2017), and a large number of preclinical and a few clinical studies (Bao et al, 2018;Henning et al, 2012;Ko, Kim, Park, & Im, 2014). (Bao et al, 2018;Guldris et al, 2017;Henning et al, 2012;Li et al, 2013;Wei et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Regeneration of hyaline cartilage in osteochondral lesion model using L‐lysine magnetic nanoparticles labeled mesenchymal stem cells and their in vivo imaging

Shelat

Bhatt

Paunipagar

et al. 2020

J Tissue Eng Regen Med

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Treatment of osteochondral defects continues to pose a major challenge for patients and orthopedic surgeons due to the limited healing potential of articular cartilage. Mesenchymal stem cells (MSCs) possess therapeutic potential for the treatment of osteochondral pain and pathology. However, it is necessary to use proper labeling and imaging agent of stem cells that can decipher its role posttransplantation. A major limitation of routinely used contrast agents is signal dilution over a period of time which limits its use for further studies. At the same time, regeneration of fibrocartilage over native hyaline cartilage also limits the use of conventional therapies. The present study evaluates the efficacy of bone marrow-derived mesenchymal stem cells (BMSCs) for the treatment of osteochondral defect in rats with the regeneration of hyaline cartilage in situ and in vivo monitoring of the stem cells using L-lysine functionalized magnetic iron oxide nanoparticles (lys-IONPs). L-lysine stabilizes the iron oxide nanoparticles, enhances the biocompatibility, and provides functionalities for efficient stem cell labeling. in vitro toxic effects of lys-IONPs on mitochondrial impairment, morphological alterations, and actin cytoskeleton reveal minimum damage to BM-MSCs. Histological data (H and E, Masson's trichrome and immunohistochemistry) describe the early initiation of healing and regeneration of hyaline-like cartilage over fibrocartilage in stem cell treated groups. MR scans demonstrate generation of hypointense signals in lys-IONPs-BMSCs with improved signal intensity and minimum loss over 28 days revealing its use as a long-term stem cell labeling and imaging agent. K E Y W O R D S bone marrow mesenchymal stem cells, iron oxide nanoparticles, L-lysine, magnetic resonance imaging, osteochondral defect 1 | INTRODUCTION Osteochondral defects in the knee joint remain to be the most challenging clinical problem for orthopedic surgeons with maximum disability in young athletes and older people (Kumbhar et al., 2017). The overall prevalence rate of osteochondral defect is found to be higher in males than in females (3:1) with young adults at the highest risk (Weiss et al., 2016). Owing to the restricted therapeutic ability of articular cartilage, it is complicated to treat osteochondral defects, leading to disabling pain and early osteoarthritis (Perera, Gikas, & Bentley, 2012). Thus,

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“…13 Mesenchymal stem cell transplantation has recently been described in a case report as a potential treatment for OCD. 14…”

Section: Discussionmentioning

confidence: 99%

A Case Report of Osteochondritis Dissecans in a Rare Location: The Lateral Femoral Trochlea

Villafañe

Holloway²,

Kettner

2017

Journal of Chiropractic Medicine

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Restoration of a large osteochondral defect of the knee using a composite of umbilical cord blood-derived mesenchymal stem cells and hyaluronic acid hydrogel: a case report with a 5-year follow-up

Cited by 25 publications

References 51 publications

Tissue Engineering for the Temporomandibular Joint

Tissue Engineering for the Temporomandibular Joint

Regeneration of hyaline cartilage in osteochondral lesion model using L‐lysine magnetic nanoparticles labeled mesenchymal stem cells and their in vivo imaging

A Case Report of Osteochondritis Dissecans in a Rare Location: The Lateral Femoral Trochlea

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