Restoration of blood pressure by choline treatment in rats made hypotensive by haemorrhage

Ulus, İsmail H.; Arslan, Bilge; Savci, Vahide; Kiran, B.K.

doi:10.1111/j.1476-5381.1995.tb16682.x

Cited by 50 publications

(44 citation statements)

References 20 publications

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“…The pressor effect of choline on normotensive rats is lower and shorter (5 min) than that in hemorrhage-induced hypotensive rats (2,4,8). The pressor effects of choline and other cholinomimetics on the cardiovascular system are associated with the sympathoadrenergic system and VP, as proven by the increase in both catecholamines and VP following central choline injection (1,6,8).…”

Section: Discussionmentioning

confidence: 99%

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Central injection of captopril inhibits the blood pressure response to intracerebroventricular choline

Isbil-Buyukcoskun

Gulec

Ozluk

et al. 2001

Braz J Med Biol Res

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In the present study, we investigated the involvement of the brain renin-angiotensin system in the effects of central cholinergic stimulation on blood pressure in conscious, freely moving normotensive rats. In the first step, we determined the effects of intracerebroventricular (icv) choline (50, 100 and 150 µg) on blood pressure. Choline increased blood pressure in a dose-dependent manner. In order to investigate the effects of brain renin-angiotensin system blockade on blood pressure increase induced by choline (150 µg, icv), an angiotensin-converting enzyme inhibitor, captopril (25 and 50 µg, icv), was administered 3 min before choline. Twenty-five µg captopril did not block the pressor effect of choline, while 50 µg captopril blocked it significantly. Our results suggest that the central renin-angiotensin system may participate in the increase in blood pressure induced by icv choline in normotensive rats. CorrespondenceN.

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Section: Discussionmentioning

confidence: 99%

“…The vasopressinergic system also mediates the effects of choline on blood pressure. Centrally injected acetylcholine and several other cholinergic agents have been shown to increase vasopressin (VP) secretion (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Central injection of captopril inhibits the blood pressure response to intracerebroventricular choline

Isbil-Buyukcoskun

Gulec

Ozluk

et al. 2001

Braz J Med Biol Res

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“…In this protocol, approximately 40% of the initial blood volume was removed by allowing a loss of 2.1-2.2 ml of blood per 100 g of body weight within 10 min [9]. The arterial catheter was then flushed with 0.1 ml of heparinised saline and reconnected to the transducer.…”

Section: Haemorrhage Protocolmentioning

confidence: 99%

“…acetylcholine itself, carbachol, oxotremorine or indirectly acting cholinergic agents, including the acetylcholine precursor choline and the acetylcholinesterase inhibitors physostigmine and neostigmine, increase blood pressure by activating central cholinergic mechanisms in conscious and anaesthetised animals [1,[3][4][5][6]. Recent studies reported that the centrally acting cholinergic drugs including choline, oxotremorine and physostigmine can restore blood pressure and increase the survival rate of rats under several hypotensive conditions such as experimental haemorrhagic shock [7][8][9], endotoxic shock [10], spinal shock [11] or even after prolonged respiratory arrest [12]. Observations from these experiments suggested that a decrease in central cholinergic tone is involved in the complex pathophysiology of shock.…”

Section: Introductionmentioning

confidence: 99%

“…Observations from these experiments suggested that a decrease in central cholinergic tone is involved in the complex pathophysiology of shock. Therefore, the enhancement of central cholinergic transmission directly by activating central cholinergic receptors or indirectly by blocking the breakdown of acetylcholine or by providing extra free choline helps to restore blood pressure and to increase survival time [7][8][9]12].…”

Section: Introductionmentioning

confidence: 99%

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Reversal of Haemorrhagic Shock in Rats by Tetrahydroaminoacridine

Savci¹,

Çavun²,

Gurun³

et al. 2001

Pharmacology

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The cardiovascular effects of tetrahydroaminoacridine (tacrine; THA) were investigated in haemorrhaged rats. Intracerebroventricular (i.c.v.) injection of THA (10, 25 and 50 µg) restored blood pressure in a dose- and time-dependent manner. Atropine (10 µg, i.c.v.), a muscarinic receptor antagonist, attenuated the pressor response to THA (25 µg, i.c.v.), while mecamylamine (50 µg, i.c.v.), a nicotinic receptor antagonist, caused only a slight blockade in the pressor effect of THA. Simultaneous pretreatment with atropine and mecamylamine almost abolished the blood pressure effect of i.c.v. THA (25 µg). Haemorrhage increased plasma levels of adrenaline, noradrenaline, vasopressin and plasma renin activity. THA (25 µg, i.c.v.) administration caused additional increases in vasopressin and adrenaline levels but not of renin activity and noradrenaline levels. The reversal of hypotension by THA was greatly attenuated by administration of either prazosin, an α₁-adrenoceptor antagonist (0.5 mg/kg, i.v.) or by the vasopressin V₁ receptor antagonist [β-mercapto-β,β-cyclopenta-methylenepropionyl¹, O-Me-Tyr²-Arg⁸]-vasopressin (10 µg/kg, i.v.). Pretreatment of rats with both prazosin and the vasopressin antagonist simultaneously completely inhibited the pressor response. Intravenous administration of THA (1, 1.5 and 3 mg/kg) also reversed hypotension in rats. Atropine (10 µg, i.c.v.) greatly attenuated the pressor response to THA (1.5 mg/kg, i.v.), while mecamylamine (50 µg, i.c.v.) failed to change the pressor effect of THA. In anaesthetised haemorrhaged rats, THA (1.5 mg/kg, i.v.) increased blood pressure and survival time of the animals. These results show that centrally and peripherally injected THA reverses haemorrhagic hypotension and increases survival time in rats. Activation of central muscarinic and nicotinic receptors is involved in the pressor response to i.c.v. THA. The pressor effect of i.v. THA is solely mediated by central muscarinic receptors. Moreover, the increase in plasma adrenaline and vasopressin levels appears to be involved in the pressor effect of THA.

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The Effects of G-CSF Treatment and Starvation on Bacterial Translocation in Hemorrhagic Shock

Agalar¹,

İskit²,

Ağalar³

et al. 1998

Journal of Surgical Research

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Restoration of blood pressure by choline treatment in rats made hypotensive by haemorrhage

Cited by 50 publications

References 20 publications

Central injection of captopril inhibits the blood pressure response to intracerebroventricular choline

Central injection of captopril inhibits the blood pressure response to intracerebroventricular choline

Reversal of Haemorrhagic Shock in Rats by Tetrahydroaminoacridine

The Effects of G-CSF Treatment and Starvation on Bacterial Translocation in Hemorrhagic Shock

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