Restoration of Corneal Transparency in a Patient with Corneal Scarring Using Mesenchyme Stem Cells: A Case Report

Ramin, Shahrokh; Abbasi, Ali; Ahadi, Masoumeh; Rad, Lina Moallemi; Tafti, Zahra Fallah

doi:10.3341/kjo.2023.0037

Cited by 1 publication

(2 citation statements)

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“…keratometry: 2.0 D improvement CCT: 31 μm increase Aberrometry findings: significantly reduced Intrastromal implantation of stem cells with a decellularized stromal scaffold: 4 eyes of 4 patients with advanced keratoconus, F/U:3 years Side effects: no evidences in examination BCVA: 0.19 lines in Log MAR scale Sph refraction: 1.2D improvement Cyl refraction: 1.1D improvement Max. keratometry: 2.0 D improvement CCT: 30 μm increase Aberrometry findings: significantly reduced Density of stromal keratocytes: increased Ramin et al (2023) [ 36 , 40 ] Intrastromal implantation of stem cells alone: Side effects: no evidences in examination 8 eyes of 8 patients with moderate to severe keratoconus, age:22–35 years, F/U: 6 months BCVA: 1.85 lines in Snellen scale Sph refraction: 0.34D improvement Cyl refraction: 0.84D improvement Ant. keratometry: 0.76D improvement CCT: 6.29 μm increase Aberrometry findings: reduced Density of stromal keratocytes: increased 1 eye with severe keratoconus and central corneal scaring, age: 65 years, F/U: 6 months Side effects: no evidences in examination BCVA: improvement of visual acuity from HM to 20/80 in Snellen scale Sph & Cyl refraction: marked improvement Keratometry: marked improvement CCT: marked improvement Aberrometry findings: marked reduced Density of stromal keratocytes: increased F/U Follow-up, BCVA Best corrected visual acuity, Sph refraction Spherical refraction, Cyl refraction Cylindrical refraction, CCT Central corneal thickness, Ant.…”

Section: Methodsmentioning

confidence: 99%

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Mini review: human clinical studies of stem cell therapy in keratoconus

Ahadi,

Ramin,

Abbasi

et al. 2024

BMC Ophthalmol

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Treatment of keratoconus is one of the most interesting research fields for researchers in the world. Regenerative medicine based on human stem cells in the treatment of keratoconus has recently received attention. Despite extensive laboratory and animal studies in regenerative medicine of cornea, there are limited clinical studies in keratoconus. These studies showed promising results of stem cell therapy. In initial studies, the transplantation of these cells into stroma was associated with increased vision and improved corneal parameters without side effects. In this article, we tried to review different aspects of keratoconus stem cell therapy, including cell extraction and culture, surgical procedure, effectiveness and safety of this method in human clinical studies.

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Section: Methodsmentioning

confidence: 99%

“…In topography finding, corneal irregularities significantly decreased and corneal thickness increased. ASCs implantation was safe and less invasive than the common corneal transplantation and can be considered as another possible option in corneal scarring [ 40 ].…”

Section: Methodsmentioning

confidence: 99%