Restoration of Critical-Size Defects in the Rabbit Mandible Using Porous Nanohydroxyapatite-Polyamide Scaffolds

Guo, Jun; Meng, Zhaosong; Chen, Gang; Xie, Dan; Chen, Yali; Wang, Hang; Tang, Wei; Liu, Lei; Wei, Jing; Long, Jie; Guo, Wei; Tian, Weidong

doi:10.1089/ten.tea.2011.0503

Cited by 50 publications

(31 citation statements)

References 46 publications

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“…The results showed the enhancement of osteogenic markers in the implanted samples with cells, showing the ability of these scaffolds to stimulate osteogenesis, although the amount of new bone formed was not enhanced in the presence of the cells. 225 Similar results were obtained using nanosized β-tricalcium phosphate within a collagen matrix, which showed enhanced bone regeneration when implanted with MSCs. 226 …”

supporting

confidence: 62%

Nanotechnology in dentistry: prevention, diagnosis, and therapy

Neel¹,

Bozec

Pérez³

et al. 2015

IJN

102

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Nanotechnology has rapidly expanded into all areas of science; it offers significant alternative ways to solve scientific and medical questions and problems. In dentistry, nanotechnology has been exploited in the development of restorative materials with some significant success. This review discusses nanointerfaces that could compromise the longevity of dental restorations, and how nanotechnolgy has been employed to modify them for providing long-term successful restorations. It also focuses on some challenging areas in dentistry, eg, oral biofilm and cancers, and how nanotechnology overcomes these challenges. The recent advances in nanodentistry and innovations in oral health-related diagnostic, preventive, and therapeutic methods required to maintain and obtain perfect oral health, have been discussed. The recent advances in nanotechnology could hold promise in bringing a paradigm shift in dental field. Although there are numerous complex therapies being developed to treat many diseases, their clinical use requires careful consideration of the expense of synthesis and implementation.

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supporting

confidence: 62%

Nanotechnology in dentistry: prevention, diagnosis, and therapy

Neel¹,

Bozec

Pérez³

et al. 2015

IJN

102

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“…Consequently, insufficient blood supply is one of the major reasons for impaired bone healing [4]. Such insufficient blood vessel ingrowth is often seen in large oral and maxillofacial defects, resulting from accidents, bone inflammation, or neoplasia, often leading to a non-union of the bone [5,6,7]. …”

Section: Introductionmentioning

confidence: 99%

Evaluation of Functionalized Porous Titanium Implants for Enhancing Angiogenesis in Vitro

et al. 2016

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Implant constructs supporting angiogenesis are favorable for treating critically-sized bone defects, as ingrowth of capillaries towards the center of large defects is often insufficient. Consequently, the insufficient nutritional supply of these regions leads to impaired bone healing. Implants with specially designed angiogenic supporting geometry and functionalized with proangiogenic cytokines can enhance angiogenesis. In this study, Vascular Endothelial Growth Factor (VEGF) and High Mobility Group Box 1 (HMGB1) were used for incorporation into poly-ε-caprolactone (PCL)-coated porous titanium implants. Bioactivity of released factors and influence on angiogenesis of functionalized implants were evaluated using a migration assay and angiogenesis assays. Both implants released angiogenic factors, inducing migration of endothelial cells. Also, VEGF-functionalized PCL-coated titanium implants enhanced angiogenesis in vitro. Both factors were rapidly released in high doses from the implant coating during the first 72 h.

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“…1,2 Although alveolar bones have the capability to regenerate, the healing process frequently fails to progress through the normal stages of healing or is delayed when the defects reach a critical size. [3][4][5] Therefore, bone grafting is necessary for large defects.…”

Section: Introductionmentioning

confidence: 99%

Angiogenesis and bone regeneration of porous nano-hydroxyapatite/coralline blocks coated with rhVEGF165 in critical-size alveolar bone defects in vivo

Du¹,

Liu²,

Deng³

et al. 2015

IJN

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To improve the regenerative performance of nano-hydroxyapatite/coralline (nHA/coral) block grafting in a canine mandibular critical-size defect model, nHA/coral blocks were coated with recombinant human vascular endothelial growth factor 165 (rhVEGF) via physical adsorption (3 μg rhVEGF 165 per nHA/coral block). After the nHA/coral blocks and VEGF/nHA/coral blocks were randomly implanted into the mandibular box-shaped defects in a split-mouth design, the healing process was evaluated by histological observation and histomorphometric and immunohistological analyses. The histological evaluations revealed the ingrowth of newly formed blood vessels and bone at the periphery and cores of the blocks in both groups at both 3 and 8 weeks postsurgery, respectively. In the histomorphometric analysis, the VEGF/nHA/coral group exhibited a larger quantity of new bone formation at 3 and 8 weeks postsurgery. The percentages of newly formed bone within the entire blocks in the VEGF/nHA/coral group were 27.3%±8.1% and 39.3%±12.8% at 3 weeks and 8 weeks, respectively, and these values were slightly greater than those of the nHA/coral group (21.7%±3.0% and 32.6%±10.3%, respectively), but the differences were not significant ( P >0.05). The immunohistological evaluations revealed that the neovascular density in the VEGF/nHA/coral group (146±32.9 vessel/mm 2 ) was much greater than that in the nHA/coral group (105±51.8 vessel/mm 2 ) at the 3-week time point ( P <0.05), but no significant difference was observed at the 8-week time point (341±86.1 and 269±50.7 vessel/mm 2 , respectively, P >0.05). The present study indicated that nHA/coral blocks might be optimal scaffolds for block grafting in critical-size mandibular defects and that additional VEGF coating via physical adsorption can promote angiogenesis in the early stage of bone healing, which suggests that prevascularized nHA/coral blocks have significant potential as a bioactive material for bone regeneration in large-scale alveolar defects.

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Restoration of Critical-Size Defects in the Rabbit Mandible Using Porous Nanohydroxyapatite-Polyamide Scaffolds

Cited by 50 publications

References 46 publications

Nanotechnology in dentistry: prevention, diagnosis, and therapy

Nanotechnology in dentistry: prevention, diagnosis, and therapy

Evaluation of Functionalized Porous Titanium Implants for Enhancing Angiogenesis in Vitro

Angiogenesis and bone regeneration of porous nano-hydroxyapatite/coralline blocks coated with rhVEGF165 in critical-size alveolar bone defects in vivo

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