Restoration of Impaired T-Cell Proliferation after Parathyroidectomy in Hemodialysis Patients

Tzanno-Martins, Carmen; Futata, E.; Jorgetti, Vanda; Duarte, Alexsis

doi:10.1159/000045581

Cited by 52 publications

(35 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A common finding associated with uremia is impaired immunity, including disorders of Tlymphocyte growth and activation, lymphopenia and decreased antigen-specific humoral immunity mediated by Tlymphocytes (12). In addition, several factors specific for HD patients, such as malnutrition, anemia, vitamin D deficiency and hyperparathyroidism, may further contribute to impaired immunity (13)(14)(15)(16). Therefore, HD patients are considered to have high susceptibility to TB, and latent TB is 52.5 times more likely to be reactivated in patients with renal failure than in the general population (1,17).…”

Section: Discussionmentioning

confidence: 99%

Tuberculous Osteomyelitis in the Ulna of a Patient Undergoing Hemodialysis

et al. 2013

View full text Add to dashboard Cite

A 76-year-old woman on hemodialysis (HD) presented with pain and swelling in the left wrist and forearm. The osteomyelitis occurred in the part of the ulna adjacent to the arteriovenous fistula. Mycobacterium tuberculosis was identified in pus obtained from the left forearm, leading to a diagnosis of tuberculous osteomyelitis. The patient was treated with anti-tuberculous drugs and her symptoms improved. In this study, we report a case of tuberculous osteomyelitis occurring in the ulna, which is not the usual site of predilection for tuberculosis infection. As HD patients exhibit a high frequency of extrapulmonary tuberculosis, tuberculous osteomyelitis should be considered in the differential diagnosis of infectious osteomyelitis. In addition, it may be useful to perform stab cultures at an early stage in order to diagnose tuberculous osteomyelitis.

show abstract

Section: Discussionmentioning

confidence: 99%

Tuberculous Osteomyelitis in the Ulna of a Patient Undergoing Hemodialysis

et al. 2013

View full text Add to dashboard Cite

show abstract

“…10 Other factors which might contribute to decreased immunity are malnutrition, vitamin D deficiency and hyperparathyroidism. 11,12 Although TB was found in most organs of the body, it was most frequently reported in the peritoneum, bone, and lymph node. Some relatively uncommon cases were also reported, including intestinal TB, renal TB, breast TB, and tuberculous orchitis.…”

Section: Discussionmentioning

confidence: 99%

Incidence of tuberculosis in nondialysis-requiring CKD patients

Narain¹,

Gupta

2018

Int J Adv Med

View full text Add to dashboard Cite

Background: Tuberculosis is a common infection of chronic kidney disease patients in developing countries.Methods: A retrospective study of 2960 non-dialysis requiring chronic kidney disease patients was made to determine the incidence and understand the demographic features of patients that lead to the development of tuberculosis on the basis of cell count, routine, ADA estimation, ZN stain, culture and PCR.Results: Between Jan 2000 and March 2017, the incidence of tuberculosis in no dialysis-requiring chronic kidney disease group was 10.3% in which pulmonary tuberculosis was 3.9% while extrapulmonary tuberculosis was 6.4%. Among extrapulmonary tuberculosis, 52% positivity was seen in pleural effusion, 16.40% in ascetic fluid, 10.10% in lymphnodes, 7.4% in urinary tract, and 3.7% in CSF, 2.6% in pericardial fluid, 1.6% in adrenal tissue and 1.1% in spine. ZN stain was positive in 48.6%, culture isolated mycobacterium 98.3%, PCR 93.4%, the mean ADA levels was 22.90+11.24 IU/ml and 60.49+07.24 IU/ml in CSF and body fluids respectively. Outcome analysis revealed 15.4% mortality rate in diagnosed tuberculosis cases while maximum loss of life was seen in diabetic patients.Conclusions:In the present study we observed 10.3% incidence of tuberculosis among nondialysis-requiring chronic kidney disease patients. Extrapulmonary form of tuberculosis predominates over pulmonary form. Unusual presentation and lococalization of symptoms should not be overlooked. Prompt and early diagnosis of tuberculosis is especially required in endemic areas.

show abstract

“…14 Parathyroidectomy also had a positive impact on nutritional status and humoral and cellular immunity. 15,16 …”

Section: Discussionmentioning

confidence: 99%

Parathyroidectomy for Refractory Secondary Hyperparathyroidism with Severe Bone Disease

Evora

Mirasol

2012

JAFES

View full text Add to dashboard Cite

Advances in the medical management of secondary hyperparathyroidism due to renal failure have decreased the use of parathyroidectomy as a treatment option. However, some patients with end-stage renal disease still progress to refractory hyperparathyroidism and debilitating bone disease, for which parathyroidectomy may be warranted. We describe a case of a 35-year-old female on chronic hemodialysis who presented with bone pains, deformities, decrease in height and recurrent pathologic fractures. She had markedly elevated parathyroid hormone (PTH), vitamin D deficiency, persistent hyperphosphatemia and hypocalcemia despite therapeutic measures. Subtotal parathyroidectomy was done with eventual improvement of biochemical abnormalities, resolution of bone pains and healing of fractures.

show abstract

Restoration of Impaired T-Cell Proliferation after Parathyroidectomy in Hemodialysis Patients

Cited by 52 publications

References 11 publications

Tuberculous Osteomyelitis in the Ulna of a Patient Undergoing Hemodialysis

Tuberculous Osteomyelitis in the Ulna of a Patient Undergoing Hemodialysis

Incidence of tuberculosis in nondialysis-requiring CKD patients

Parathyroidectomy for Refractory Secondary Hyperparathyroidism with Severe Bone Disease

Contact Info

Product

Resources

About