Restoration of mechanically lengthened jejunum into intestinal continuity in rats

Stark, Rebecca; Zupekan, Tatiana; Bondada, Sandhya; Dunn, James C.Y.

doi:10.1016/j.jpedsurg.2011.09.019

Cited by 22 publications

(10 citation statements)

References 20 publications

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“…Intestinal smooth muscle hypertrophy was seen with mechanical stimulation in an animal model, and the cell proliferation was increased by mechanical stimulation. (18)(19)(20).…”

Section: Discussionmentioning

confidence: 99%

Histological study of the elongated esophagus in a rat model

Inoue

Kosaka

Takatsuki

et al. 2015

Journal of Surgical Research

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“…Intestinal smooth muscle hypertrophy was seen with mechanical stimulation in an animal model, and the cell proliferation was increased by mechanical stimulation. (18)(19)(20).…”

Section: Discussionmentioning

confidence: 99%

Histological study of the elongated esophagus in a rat model

Inoue

Kosaka

Takatsuki

et al. 2015

Journal of Surgical Research

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“…The idea of tissue expansion is not a new one and is well known in orthopaedic and reconstructive surgery [22, 23]. The elongation of intestines was first performed in 1990 with an inflatable silicon balloon; however, not just the length but also the diameter was increased [12].…”

Section: Discussionmentioning

confidence: 99%

Mechanical Elongation of the Small Intestine: Evaluation of Techniques for Optimal Screw Placement in a Rodent Model

Hausbrandt

Ainoedhofer

Saxena

et al. 2013

BioMed Research International

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Introduction. The aim of this study was to evaluate techniques and establish an optimal method for mechanical elongation of small intestine (MESI) using screws in a rodent model in order to develop a potential therapy for short bowel syndrome (SBS). Material and Methods. Adult female Sprague Dawley rats (n = 24) with body weight from 250 to 300 g (Σ = 283) were evaluated using 5 different groups in which the basic denominator for the technique involved the fixation of a blind loop of the intestine on the abdominal wall with the placement of a screw in the lumen secured to the abdominal wall. Results. In all groups with accessible screws, the rodents removed the implants despite the use of washers or suits to prevent removal. Subcutaneous placement of the screw combined with antibiotic treatment and dietary modifications was finally successful. In two animals autologous transplantation of the lengthened intestinal segment was successful. Discussion. While the rodent model may provide useful basic information on mechanical intestinal lengthening, further investigations should be performed in larger animals to make use of the translational nature of MESI in human SBS treatment.

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“…This design has the benefit of being completely intraluminal as well as the advantage of timed spring deployment. Isolated segments were lengthened on average four fold and demonstrated the common findings of villous atrophy and smooth muscle hyperplasia [40,41,42,43]. Lastly, this design has been effectively used to both lengthen the isolated intestine and for restoration of the lengthened intestine back into intestinal continuity, Figure 7 [43].…”

Section: Current Study Designs For Mechanical Bowel Lengtheningmentioning

confidence: 98%

Mechanical Enterogenesis ‐ A Review

Stark¹,

Dunn²

2012

Journal of Healthcare Engineering

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Mechanical enterogenesis is a novel method of lengthening pre-existing intestine with distractive force. The application of mechanical force on small intestine aims to induce cellular proliferation and ultimately increase bowel length. This has been investigated primarily for the treatment of short bowel syndrome (SBS). Research has been ongoing for well over a decade in this arena and a multitude of advances have been made, both in the understanding of the biology behind force induced cellular proliferation and in the basic mechanics of force delivery systems. Important experimental models have been developed for studying this phenomenon and the collaboration of engineers and medical researchers has lead to the design of several devices that successfully lengthen small intestine. This has catapulted the field forward and there may soon be a device suitable for medical use in humans. This review analyses the past, present and future of mechanical enterogenesis.

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Restoration of mechanically lengthened jejunum into intestinal continuity in rats

Cited by 22 publications

References 20 publications

Histological study of the elongated esophagus in a rat model

Histological study of the elongated esophagus in a rat model

Mechanical Elongation of the Small Intestine: Evaluation of Techniques for Optimal Screw Placement in a Rodent Model

Mechanical Enterogenesis ‐ A Review

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