Restoration of Thyroid Secretion in Uremic Patients following a Low Protein Low Phosphorus Diet Supplemented with Essential Amino Acids and Keto Analogues

Effects of a Low-Phosphorus, Low-Nitrogen Diet Supplemented with Essential Amino Acids and Ketoanalogues on Serum Beta-Endorphin in Chronic Renal Failure

“…The increase of T3 during the SD. previously described [12], was attributed to the decrease of PTH levels [23]. Also, this endocrine change may be regarded as a consequence of the fall of circulating [)-EP and of the decrease of PTH levels.…”

“…FSH) [4,5], prolactin (PRL) [2] and to cause glucose intolerance [6]. Circulating P-endorphin ((3-EP) is high in CRF and this is the most active of these compounds [7], Some years ago a very low-protein diet supplemented with essential amino acids and ketoanalogues (supple mented diet, SD) was introduced in the treatment of severe C R F [8) and it was found that it can slow down the rate of decline of the residual renal function [8,9], reverse secondary hyperparathyroidism [10,II], improve TSH and Tj levels [12], and restore gonadal testosterone (T) secretion in males [13]. Also, glucose tolerance improves after treatment with SD [14].…”

Dietary Treatment as Seen by German Nephrologists

“…However, there is no consent with regard to which protein-re stricted diet should be given. Unselective protein restriction and the potato-egg diet are presently more frequently prescribed than a diet supplemented with amino acids and keto analogues, though there is mount ing evidence that the latter might be the superior diet [3][4][5][6][7],…”