2011
DOI: 10.1038/onc.2011.234
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Restoration of tumor suppressor p53 by differentially regulating pro- and anti-p53 networks in HPV-18-infected cervical cancer cells

Abstract: Abrogation of functional p53 is responsible for malignant cell transformation and maintenance of human papilloma virus (HPV)-infected cancer cells. Restoration of p53 has, therefore, been regarded as an important strategy for molecular intervention of HPV-associated malignancies. Here we report that differential regulation of pro-and anti-p53 setups not only upregulates p53 transcription but also stabilizes and activates p53 protein to ensure p53-induced apoptosis in HPV-18-infected cervical cancer. Functional… Show more

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Cited by 33 publications
(26 citation statements)
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“…The cells were routinely maintained in complete Dulbecco's modified Eagle's medium at 37°C in a humidified incubator containing 5% CO 2 (26). Cells were allowed to reach confluence before use.…”
Section: Methodsmentioning
confidence: 99%
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“…The cells were routinely maintained in complete Dulbecco's modified Eagle's medium at 37°C in a humidified incubator containing 5% CO 2 (26). Cells were allowed to reach confluence before use.…”
Section: Methodsmentioning
confidence: 99%
“…Cells were allowed to reach confluence before use. Viable cell numbers were determined by trypan blue exclusion test (26). Cells were treated with different concentrations of curcumin (Sigma) for different time points to select the optimum dose and time required for cancer cell apoptosis.…”
Section: Methodsmentioning
confidence: 99%
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“…Therefore, targeting NFκB pathway may serve as a novel approach to regress NSCLC cells. Conversely, tumor suppressor p53, the 'guardian of genome' translates stress signals into cell cycle arrest or apoptosis, depending on the balance between pro-apoptotic and anti-proliferative genes (29)(30)(31). Thus, drugs reviving tumor suppressor functions of p53 will be proficient for targeted cancer therapy.…”
Section: Sulphur Alters Nfκb-p300 Cross-talk In Favour Of P53-p300mentioning
confidence: 99%