Restorative effects of gallic acid against sub-chronic hepatic toxicity of co-exposure to zinc oxide nanoparticles and arsenic trioxide in male rats

Arsenic trioxide-induced cardiotoxicity: the protective effect of 2-aminoethoxydiphenyl-borate

“…A previous study showed that arsenic ions in arsenic trioxide can bind with hydroxyl and thiol groups in enzyme protein molecules in the body, thereby reducing antioxidant enzyme activity [11] . SOD is an important antioxidant enzyme in the body that can eliminate harmful substances produced during metabolism, glutathione peroxidase (GSH-px) and catalase (CAT) are important peroxidase-decomposing enzymes in organisms that can protect the structure and function of cell membranes from oxidative damage, and glutathione S-transferase (GST) is a key enzyme in the glutathione binding reaction, with antioxidant and detoxifying effects [12] . When oxidative stress occurs, intracellular lipids are oxidized, producing large amounts of malondialdehyde (MDA) and lipid hydroperoxide (LOOH) [11] .…”