Restorative Effects of Inulin From Codonopsis pilosula on Intestinal Mucosal Immunity, Anti-Inflammatory Activity and Gut Microbiota of Immunosuppressed Mice

Zou, Yuanfeng; Li, Cen-Yu; Fu, Yuping; Feng, Xin; Peng, Xi; Feng, Bin; Li, Lixia; Jia, Renyong; Huang, Chao; Song, Xu; Lü, Cheng; Ye, Gang; Zhao, Ling; Li, Yangping; Zhao, Xinghong; Yin, Lizi

doi:10.3389/fphar.2022.786141

Cited by 18 publications

(9 citation statements)

References 58 publications

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“…It contributes to intestinal barrier function ( Planer et al., 2016 ) and passive immunization of sIgA for combating enteric diseases ( Richards et al., 2021 ). Remarkably, polysaccharides could promote sIgA from many traditional medicines ( Zou et al., 2022b ). TB can likewise increase intestinal sIgA secretion to a certain extent.…”

Section: Discussionmentioning

confidence: 99%

Preventive effect of Terminalia bellirica (Gaertn.) Roxb. extract on mice infected with Salmonella Typhimurium

Kong

Shang²,

Liu³

et al. 2023

Front. Cell. Infect. Microbiol.

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Terminalia bellirica (Gaertn.) Roxb. (TB) is a traditional herbal combination used in Chinese medicine for the treatment of a broad range of diseases. In this study, thirty KM mice were randomly divided into control (N), infection group (NS), and the TB protection group (HS). Based on its digestive feature, intestinal physical barrier, immunological barrier and gut microbiota effects in vivo on challenged with S.typhimurium mice were investigated after oral administration of 600 mg/kg b.wt of TB for 13 days. The results show that the extract could improve the level of serum immunoglobulins (IgA and IgG), decrease the intestinal cytokine secretion to relieve intestinal cytokine storm, reinforce the intestinal biochemical barrier function by elevating the sIgA expression, and strengthen the intestinal physical barrier function. Simultaneously, based on the V3–V4 region of the 16S rRNA analyzed, the results of the taxonomic structure of the intestinal microbiota demonstrated that the TB prevention effect transformed the key phylotypes of the gut microbiota in S. Typhimurium-challenged mice and promoted the multiplication of beneficial bacteria. Furthermore, the abundance of Firmicutes and Deferribacteres increased, while that of Bacteroidetes and Actinobacteria decreased. At the genus level, the abundance of Ruminococcus and Oscillospira was substantially enhanced, while the other dominant genera showed no significant change between the vehicle control groups and the TB prevention groups. In summary, these results provide evidence that the administration of TB extract can prevent S. Typhimurium infection by alleviating the intestinal physical and immunological barriers and normalizing the gut microbiota, highlighting a promising application in clinical treatment. Thus, our results provide new insights into the biological functions of TB for the preventive effect of intestinal inflammation.

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Section: Discussionmentioning

confidence: 99%

Preventive effect of Terminalia bellirica (Gaertn.) Roxb. extract on mice infected with Salmonella Typhimurium

Kong

Shang²,

Liu³

et al. 2023

Front. Cell. Infect. Microbiol.

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“…Although, CVP-AP-I could significantly reduce the levels of serum inflammatory factors and liver function indicators ALT and AST, and significantly increase the activity of serum antioxidant enzymes. However, polysaccharides as macromolecules may mainly relay on its indirect effect to liver and the intestine, as reported by our group and other researchers (43,44). Therefore, we further evaluated the effect of CVP-AP-I on antioxidant and antiinflammatory capacity of gut and liver in naturally aging mice.…”

Section: Cvp-ap-i Attenuates Oxidative Stress and Inflammation In The...mentioning

confidence: 74%

Polysaccharide from aerial part of Chuanminshen violaceum alleviates oxidative stress and inflammatory response in aging mice through modulating intestinal microbiota

Zou

JiZe

et al. 2023

Front. Immunol.

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Aging is a biological process of progressive deterioration of physiological functions, which poses a serious threat to individual health and a heavy burden on public health systems. As population aging continues, research into anti-aging drugs that prolong life and improve health is of particular importance. In this study, the polysaccharide from stems and leaves of Chuanminshen violaceum was obtained with water extraction and alcohol precipitation, and then separated and purified with DEAE anion exchange chromatography and gel filtration to obtain CVP-AP-I. We gavaged natural aging mice with CVP-AP-I and performed serum biochemical analysis, histological staining, quantitative real-time PCR (qRT-PCR) and ELISA kit assays to analyze inflammation and oxidative stress-related gene and protein expression in tissues, and 16SrRNA to analyze intestinal flora. We found that CVP-AP-I significantly improved oxidative stress and inflammatory responses of the intestine and liver, restored the intestinal immune barrier, and balanced the dysbiosis of intestinal flora. In addition, we revealed the potential mechanism behind CVP-AP-I to improve intestinal and liver function by regulating intestinal flora balance and repairing the intestinal immune barrier to regulate the intestinal-liver axis. Our results indicated that C. violaceum polysaccharides possessed favorable antioxidant, anti-inflammatory and potentially anti-aging effects in vivo.

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“…The principal coordinates analysis (PCoA) plot indicated all the differences and similarities between the bacterial communities of the groups using weighted UniFrac distances. 35 The PBS group was dispersed but in close proximity, reflecting similar species compositions and structures, while the model and β-CH groups showed migration and aggregation. Furthermore, the β-CH group exhibited a larger span, indicating different species compositions and structures from the other groups (Fig.…”

Section: Resultsmentioning

confidence: 96%

Protective effect of β-carotene on OVA-induced food allergy in mice by strengthening intestinal epithelial barrier function and regulating intestinal microflora

Kuang

Liu

2022

Food Funct.

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Restorative Effects of Inulin From Codonopsis pilosula on Intestinal Mucosal Immunity, Anti-Inflammatory Activity and Gut Microbiota of Immunosuppressed Mice

Cited by 18 publications

References 58 publications

Preventive effect of Terminalia bellirica (Gaertn.) Roxb. extract on mice infected with Salmonella Typhimurium

Preventive effect of Terminalia bellirica (Gaertn.) Roxb. extract on mice infected with Salmonella Typhimurium

Polysaccharide from aerial part of Chuanminshen violaceum alleviates oxidative stress and inflammatory response in aging mice through modulating intestinal microbiota

Protective effect of β-carotene on OVA-induced food allergy in mice by strengthening intestinal epithelial barrier function and regulating intestinal microflora

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