Restoring heart function and electrical integrity: closing the circuit

Monteiro, Luís Miguel; Vasques‐Nóvoa, Francisco; Ferreira, Lino; Pinto-do-Ó, Perpétua; Nascimento, Diana S.

doi:10.1038/s41536-017-0015-2

Cited by 59 publications

(49 citation statements)

References 123 publications

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“…Direct and indirect costs of heart disease in the United States during 2013 was estimated at $204.8 billion and is expected to double by 2030 . The gold standards of drugs, implanted devices and transplants are of indispensable importance, but have inherent drawbacks including side effects, time‐limited use and limited supply, respectively . Given such a dire need for treatments, tissue engineering arose as one strategy to combat the symptoms of disease by regenerating or replacing damaged tissue.…”

Section: Conductive Scaffolds For Cardiac Tissue Engineeringmentioning

confidence: 99%

“…The basic principle of tissue engineering seeks to encourage cell growth by mimicking the ECM, which will encourage cells to produce their own ECM. Recent key advancements have been centered on conductivity hypotheses of scaffolds to electronically bridge the gap between cell clusters thus yielding more robust phenotype . Electroactive, topographical and mechanical scaffold properties are pertinent to achieving this goal.…”

Section: Conductive Scaffolds For Cardiac Tissue Engineeringmentioning

confidence: 99%

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Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms

Burnstine‐Townley

Eshel

Amdursky

2019

Adv Funct Materials

119

102

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Tissue engineering is a promising therapeutic approach in medicine, targeting the replacement of a diseased tissue with a healthy one grown within an artificial scaffold. Due to the high prevalence of cardiac and brain‐related ailments that involve some necrosis of tissue, cardiac and neuronal tissue engineering are intensely studied fields in regenerative medicine. A growing trend in the use of conductive scaffolds for the growth of these tissues has been witnessed recently. While the results are irrefutable, the mechanism of how an electrically conducting scaffold interacts with an electroactive tissue remains has remained elusive. An up‐to‐date summary of all work done in the field is reported, with a special focus on the specific contribution of the conductive scaffold on the performance of the formed tissue. The cell–scaffold electronic interface is then explored from an electrical engineering perspective. The electronic configuration of the system and the mechanisms and governing factors controlling the ability of a conductive scaffold to support cardiac and neuronal tissues are discussed. Using several simulations, the required conductivity of the scaffold in order for it to be suitable for tissue engineering—which also depends on the nature of the charge carriers—is also discussed.

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Section: Conductive Scaffolds For Cardiac Tissue Engineeringmentioning

confidence: 99%

Section: Conductive Scaffolds For Cardiac Tissue Engineeringmentioning

confidence: 99%

Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms

Burnstine‐Townley

Eshel

Amdursky

2019

Adv Funct Materials

119

102

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show abstract

“…Recent advancements in the field of material chemistry and microfabrication have allowed the engineering of a variety of cell-laden and acellular cardiac patches, which are based on both synthetic and naturally-derived biomaterials [12,[15][16][17][18][19][20]. However, since electromechanical coupling is essential for the contractile function of the heart, alternative strategies to restore electrical conductivity at the site of MI should also be investigated [21].…”

Section: Introductionmentioning

confidence: 99%

Engineering a naturally-derived adhesive and conductive cardiopatch

et al. 2019

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Myocardial infarction (MI) leads to a multi-phase reparative process at the site of damaged heart that ultimately results in the formation of non-conductive fibrous scar tissue. Despite the widespread use of electroconductive biomaterials to increase the physiological relevance of bioengineered cardiac tissues in vitro, there are still several limitations associated with engineering biocompatible scaffolds with appropriate mechanical properties and electroconductivity for cardiac tissue regeneration. Here, we introduce highly adhesive fibrous scaffolds engineered by electrospinning of gelatin methacryloyl (GelMA) followed by the conjugation of a choline-based bio-ionic liquid (Bio-IL) to develop conductive and adhesive cardiopatches. These GelMA/Bio-IL adhesive patches were optimized to exhibit mechanical and conductive properties similar to the native myocardium. Furthermore, the engineered patches strongly adhered to murine myocardium due to the formation of ionic bonding between the Bio-IL and native tissue, eliminating the need for suturing. Co-cultures of primary cardiomyocytes and cardiac fibroblasts grown on GelMA/Bio-IL patches exhibited comparatively better contractile profiles compared to pristine GelMA controls, as demonstrated by over-expression of the gap junction protein connexin 43. These cardiopatches could be used to provide mechanical support and restore electromechanical coupling at the site of MI to minimize cardiac remodeling and preserve normal cardiac function.

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“…Much effort has been made in replacing damaged myocardium with adult/mature cardiomyocytes (CMs), those of which are derived from pluripotent stem cells or reprogramming strategies [ 1 , 2 ]. However, several major technical limitations are compromising the success of an implantable, mature, cardiac muscle patch, including low numbers of surviving implanted CMs and the lack of electromechanical and structural integration between the host and donor CMs [ 3 , 4 ]. More recently, emerging scientific evidence has begun to emphasize the use of cardiac progenitor cells (CPCs), rather than differentiated CMs, as a novel treatment strategy for cardiac regeneration.…”

Section: Introductionmentioning

confidence: 99%

Cardiac Progenitor Cells in Basic Biology and Regenerative Medicine

Witman

Sahara

2018

Stem Cells International

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Major cardiovascular events including myocardial infarction (MI) continue to dominate morbidity rates in the developed world. Although multiple device therapies and various pharmacological agents have been shown to improve patient care and reduce mortality rates, clinicians and researchers alike still lack a true panacea to regenerate damaged cardiac tissue. Over the previous two to three decades, cardiovascular stem cell therapies have held great promise. Several stem cell-based approaches have now been shown to improve ventricular function and are documented in preclinical animal models as well as phase I and phase II clinical trials. More recently, the cardiac progenitor cell has begun to gain momentum as an ideal candidate for stem cell therapy in heart disease. Here, we will highlight the most recent advances in cardiac stem/progenitor cell biology in regard to both the basics and applied settings.

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Restoring heart function and electrical integrity: closing the circuit

Cited by 59 publications

References 123 publications

Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms

Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms

Engineering a naturally-derived adhesive and conductive cardiopatch

Cardiac Progenitor Cells in Basic Biology and Regenerative Medicine

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