Restoring motor control and sensory feedback in people with upper extremity amputations using arrays of 96 microelectrodes implanted in the median and ulnar nerves

Davis, Tyler; Wark, Heather A.C.; Hutchinson, Douglas T.; Warren, David J.; O’Neill, Kevin; Scheinblum, T.; Clark, Gregory A.; Normann, Richard A.; Greger, Bradley

doi:10.1088/1741-2560/13/3/036001

Cited by 282 publications

(262 citation statements)

References 80 publications

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“…These two techniques permit identification of anatomical organisation of fascicles but not their functional activity. This has been extensively studied using microelectrodes or, more recently, multielectrode arrays which are linear or 2D [7][8][9][10]. However, these only provide a limited subset of spiking activity from the several thousand axons present in most peripheral nerves, according to the chance apposition of the recording contacts.…”

Section: Introductionmentioning

confidence: 99%

Imaging fast neural traffic at fascicular level with electrical impedance tomography: proof of principle in rat sciatic nerve

Donegá²,

et al. 2018

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Objective. Understanding the coding of neural activity in nerve fascicles is a high priority in computational neuroscience, electroceutical autonomic nerve stimulation and functional electrical stimulation for treatment of paraplegia. Unfortunately, it has been little studied as no technique has yet been available to permit imaging of neuronal depolarization within fascicles in peripheral nerve. Approach. We report a novel method for achieving this, using a flexible cylindrical multi-electrode cuff placed around nerve and the new medical imaging technique of fast neural electrical impedance tomography (EIT). In the rat sciatic nerve, it was possible to distinguish separate fascicles activated in response to direct electrical stimulation of the posterior tibial and common peroneal nerves. Main results. Reconstructed EIT images of fascicular activation corresponded with high spatial accuracy to the appropriate fascicles apparent in histology, as well as the inverse source analysis (ISA) of compound action potentials (CAP). With this method, a temporal resolution of 0.3 ms and spatial resolution of less than 100 µm was achieved. Significance. The method presented here is a potential solution for imaging activity within peripheral nerves with high spatial accuracy. It also provides a basis for imaging and selective neuromodulation to be incorporated in a single implantable nonpenetrating peri-neural device.

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Section: Introductionmentioning

confidence: 99%

Imaging fast neural traffic at fascicular level with electrical impedance tomography: proof of principle in rat sciatic nerve

Donegá²,

et al. 2018

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“…For example, the Utah array has been used to explore restoration of tactile and proprioceptive feedback where patterned stimuli are provided as current pulses of 20–80 μA to the human sensory cortex (14). Furthermore, the Utah slant array, consisting of shanks of decreasing length to allow access to fascicular structures, has emerged as one of several strategies for peripheral nerve stimulation (15). These arrays have feature sizes an order of magnitude smaller than those of DBS electrodes and offer enhanced specificity for more precise and selective delivery of stimulation.…”

Section: Introductionmentioning

confidence: 99%

Thinking Small: Progress on Microscale Neurostimulation Technology

Pancrazio

Deku

Ghazavi

et al. 2017

Neuromodulation: Technology at the Neural Interface

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Objectives Neural stimulation is well-accepted as an effective therapy for a wide range of neurological disorders. While the scale of clinical devices is relatively large, translational and pilot clinical applications are underway for microelectrode-based systems. Microelectrodes have the advantage of stimulating a relatively small tissue volume which may improve selectivity of therapeutic stimuli. Current microelectrode technology is associated with chronic tissue response which limits utility of these devices for neural recording and stimulation. One approach for addressing the tissue response problem may be to reduce physical dimensions of the device. “Thinking small” is a trend for the electronics industry, and for implantable neural interfaces, the result may be a device that can evade the foreign body response. Materials and Methods This review paper surveys our current understanding pertaining to the relationship between implant size and tissue response and the state-of-the-art in ultra-small microelectrodes. A comprehensive literature search was performed using PubMed, Web of Science (Clarivate Analytics), and Google Scholar. Results The literature review shows recent efforts to create microelectrodes that are extremely thin appear to reduce or even eliminate the chronic tissue response. With high charge capacity coatings, ultra-microelectrodes fabricated from emerging polymers and amorphous silicon carbide appear promising for neurostimulation applications. Conclusion We envision the emergence of robust and manufacturable ultra-microelectrodes that leverage advanced materials where the small cross-sectional geometry enables compliance within tissue. Nevertheless, future testing under in vivo conditions is particularly important for assessing the stability of thin film devices under chronic stimulation.

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“…Polymer-based devices made out of a polyimide-thin-film sandwich showed to be an alternative [9] to intraneural [2] and cuff-electrode [1] arrays to chronically interface peripheral nerves in humans in the upper extremity. Stability of thin-film metallization is the key parameter that limits long-term implantation of these neural interfaces.…”

Section: Discussionmentioning

confidence: 99%

“…Upper limb interfaces are under investigation if hand grasp shall be restored after spinal cord injury or stroke or if sensory feedback shall be delivered after hand amputation in prosthetic hand control or phantom limb pain treatment. Different nerve interface concepts were recently investigated in subchronic and chronic clinical trials on the ulnar and median nerve: circumneural cuff-electrodes [1], micromachined intraneural needle arrays [2] and flexible, polymerbased intrafascicular electrodes [3]. Our approach of a transversial intrafascicular multichannel electrodes (TIME) has been developed with a focus to treat phantom limb pain after hand amputation [3]- [5].…”

Section: Introductionmentioning

confidence: 99%

On Biocompatibility and Stability of Transversal Intrafascicular Multichannel Electrodes—TIME

Boretius¹,

Čvančara

Guiraud

et al. 2016

Biosystems &Amp; Biorobotics

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Restoring motor control and sensory feedback in people with upper extremity amputations using arrays of 96 microelectrodes implanted in the median and ulnar nerves

Abstract: This study demonstrated that an array of 96 microelectrodes can be implanted into the human peripheral nervous system for up to 1 month durations. Such an array could provide intuitive control of a virtual prosthetic hand with broad sensory feedback.

Cited by 282 publications

References 80 publications

Imaging fast neural traffic at fascicular level with electrical impedance tomography: proof of principle in rat sciatic nerve

Imaging fast neural traffic at fascicular level with electrical impedance tomography: proof of principle in rat sciatic nerve

Thinking Small: Progress on Microscale Neurostimulation Technology

On Biocompatibility and Stability of Transversal Intrafascicular Multichannel Electrodes—TIME

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