Restoring the Autonomic Balance in an Atrial Fibrillation Rat Model by Electroacupuncture at the Neiguan Point

Su, Yang; Huang, Jing; Sun, Shengxuan; He, Ting; Wang, Taiyi; Fan, Mengyue; H, Yu; Yan, Jun; Ye, Lin; Xia, Yucen; Zhang, Meng; Zheng, Yao; Luο, Xingguang; Zhang, Yuewen; Lü, Manqi; Zou, Meixia; Liu, Cun‐Zhi; Chen, Yongjun

doi:10.1016/j.neurom.2022.11.005

Cited by 3 publications

(2 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Neiguan (PC6) point lies between the palmaris longus tendon and the flexor carpi radialis tendon, through which the median nerve trunk passes. Some studies [37][38][39] suggested that median nerve stimulation can reduce sympathetic nerve tension and increase vagal nerve tension. Acupuncture is an exogenous physical therapy that has a wide range of functions.…”

Section: Neuromodulation: Af Treatment Using Neiguan Point Stimulationmentioning

confidence: 99%

Research progress on central autonomic nervous mechanism of acupuncture at Neiguan point in the treatment of atrial fibrillation

Huang

Yan

Wang

et al. 2023

Acupuncture and Herbal Medicine

View full text Add to dashboard Cite

Atrial fibrillation (AF) is the most common arrhythmia disease and is associated with several cardiovascular and cerebrovascular diseases. Consequently，the mortality rate of AF has increased in recent years. At present, the treatment of AF is mainly based on medication and radiofrequency ablation, but there are limitations such as adverse reactions and high recurrence rates. Recently, autonomic nervous regulation has become a new treatment for AF. Our previous study showed that acupuncture at Neiguan (PC6) point can treat AF by regulating autonomic balance. The autonomic nervous system can be structurally divided into the central autonomic nervous (CAN) and the peripheral autonomic nervous（PAN）. Several studies have shown a correlation between acupuncture and the treatment of AF and CAN. In the clinic the positive effect of acupuncture on AF has been realized gradually, and growing experimental studies have further discovered the potential mechanism of acupuncture on AF by regulating the CAN. Therefore, this review mainly focuses on summarizing the CAN mechanism related to acupuncture in the treatment of AF to provide new ideas and directions for the treatment of AF.

show abstract

Section: Neuromodulation: Af Treatment Using Neiguan Point Stimulationmentioning

confidence: 99%

Research progress on central autonomic nervous mechanism of acupuncture at Neiguan point in the treatment of atrial fibrillation

Huang

Yan

Wang

et al. 2023

Acupuncture and Herbal Medicine

View full text Add to dashboard Cite

show abstract

“…Recent evidence suggests that the ANS is a key neural pathway in acupuncture signaling [6][7] . Hegu (LI4) [8] , Zusanli (ST36) [9] , Neiguan (PC6) [10] can bidirectionally regulate sympathetic and vagal activity. Acupuncture reduces visceral dysfunction and inflammation, relieves pain, and restores homeostasis by modulating the ANS [11] .…”

Section: Introductionmentioning

confidence: 99%

Research Progress of Acupuncture Analgesia Based on Autonomic Nerve Regulation Pathway

Pang,

Chen,

Lan

et al. 2023

Acupuncture and Herbal Medicine

View full text Add to dashboard Cite

The autonomic nervous system (ANS) includes the sympathetic, parasympathetic, and enteric nervous systems, and its senior regulatory center includes the brainstem, cingulate gyrus, and hypothalamus. Acupuncture can affect visceral, vascular, and glandular functions via the autonomic nervous regulatory pathway. In this paper, the relationship between pain and autonomic nervous function, the application of acupuncture guided by the autonomic nervous system, and the basis and clinical research on acupuncture analgesia are reviewed.

show abstract

Modulating activity of PVN neurons prevents atrial fibrillation induced circulation dysfunction by electroacupuncture at BL15

Wang,

Zhang,

Yao

et al. 2023

Chin Med

Self Cite

View full text Add to dashboard Cite

Background Circulation dysfunction is a major contributing factor to thrombosis in patients with atrial fibrillation (AF) for which effective interventions are lacking. Growing evidence indicates that regulating the paraventricular nucleus (PVN), an autonomic control center, could offer a novel strategy for treating cardiovascular and circulatory diseases. Concurrently, electroacupuncture (EA) at Xinshu (BL15), a form of peripheral nerve stimulation, has shown efficacy in treating several cardiovascular conditions, although its specific mechanism remains unclear. This study aimed to assess the impact of EA at BL15 on circulatory dysfunction in a rat AF model and investigate the pivotal role of PVN neuronal activity. Methods To mimic the onset of AF, male SD rats received tail intravenous injection of ACh-CaCl2 and were then subjected to EA at BL15, sham EA, or EA at Shenshu (BL23). Macro- and micro-circulation function were evaluated using in vivo ultrasound imaging and laser doppler testing, respectively. Vasomotricity was assessed by measuring dimension changes during vascular relaxation and contraction. Vascular endothelial function was measured using myograph, and the activation of the autonomic nerve system was evaluated through nerve activity signals. Additionally, chemogenetic manipulation was used to block PVN neuronal activation to further elucidate the role of PVN activation in the prevention of AF-induced blood circulation dysfunction through EA treatment. Results Our data demonstrate that EA at BL15, but not BL23 or sham EA, effectively prevented AF-induced macro- and micro-circulation dysfunction. Furthermore, EA at BL15 restored AF-induced vasomotricity impairment. Additionally, EA treatment prevented abnormal activation of the autonomic nerve system induced by AF, although it did not address vascular endothelial dysfunction. Importantly, excessive activation of PVN neurons negated the protective effects of EA treatment on AF-induced circulation dysfunction in rats. Conclusion These results indicate that EA treatment at BL15 modulates PVN neuronal activity and provides protection against AF-induced circulatory dysfunction.

show abstract

Restoring the Autonomic Balance in an Atrial Fibrillation Rat Model by Electroacupuncture at the Neiguan Point

Cited by 3 publications

References 79 publications

Research progress on central autonomic nervous mechanism of acupuncture at Neiguan point in the treatment of atrial fibrillation

Research progress on central autonomic nervous mechanism of acupuncture at Neiguan point in the treatment of atrial fibrillation

Research Progress of Acupuncture Analgesia Based on Autonomic Nerve Regulation Pathway

Modulating activity of PVN neurons prevents atrial fibrillation induced circulation dysfunction by electroacupuncture at BL15

Contact Info

Product

Resources

About