Restoring the imaging quality of circular transducer array-based PACT using synthetic aperture focusing technique integrated with 2nd-derivative-based back projection scheme

Gao, Rongkang; Chen, Tao; Ren, Yongmao; Liu, Liangjian; Chen, Ningbo; Wong, Kenneth K.; Liu, Song; Ma, Xiaohui; Liu, Chengbo

doi:10.1016/j.pacs.2023.100537

Cited by 6 publications

(1 citation statement)

References 41 publications

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“… 1 – 5 By converting optical energy into acoustic energy, which is two to three orders of magnitude less scattered than photons, PA imaging surpasses the optical diffusion limit of 1 mm in biological tissue and significantly extends the imaging depth to ranges that are inaccessible by conventional optical imaging techniques. 1 , 6 – 12 Unlike conventional ultrasound imaging methods that rely on mechanical properties for contrast generation, PA imaging retains the rich optical absorption contrast derived from photon absorption. 5 , 13 , 14 These distinctive features make PA imaging a revolutionary modality with broad applications in biomedical research.…”

Section: Introductionmentioning

confidence: 99%

Influence mechanism of the temporal duration of laser irradiation on photoacoustic technique: a review

Gao,

Liu,

et al. 2024

J. Biomed. Opt.

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. Significance In the photoacoustic (PA) technique, the laser irradiation in the time domain (i.e., laser pulse duration) governs the characteristics of PA imaging—it plays a crucial role in the optical-acoustic interaction, the generation of PA signals, and the PA imaging performance. Aim We aim to provide a comprehensive analysis of the impact of laser pulse duration on various aspects of PA imaging, encompassing the signal-to-noise ratio, the spatial resolution of PA imaging, the acoustic frequency spectrum of the acoustic wave, the initiation of specific physical phenomena, and the photothermal–PA (PT-PA) interaction/conversion. Approach By surveying and reviewing the state-of-the-art investigations, we discuss the effects of laser pulse duration on the generation of PA signals in the context of biomedical PA imaging with respect to the aforementioned aspects. Results First, we discuss the impact of laser pulse duration on the PA signal amplitude and its correlation with the lateral resolution of PA imaging. Subsequently, the relationship between the axial resolution of PA imaging and the laser pulse duration is analyzed with consideration of the acoustic frequency spectrum. Furthermore, we examine the manipulation of the pulse duration to trigger physical phenomena and its relevant applications. In addition, we elaborate on the tuning of the pulse duration to manipulate the conversion process and ratio from the PT to PA effect. Conclusions We contribute to the understanding of the physical mechanisms governing pulse-width-dependent PA techniques. By gaining insight into the mechanism behind the influence of the laser pulse, we can trigger the pulse-with-dependent physical phenomena for specific PA applications, enhance PA imaging performance in biomedical imaging scenarios, and modulate PT-PA conversion by tuning the pulse duration precisely.

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Section: Introductionmentioning

confidence: 99%

Influence mechanism of the temporal duration of laser irradiation on photoacoustic technique: a review

Gao,

Liu,

et al. 2024

J. Biomed. Opt.

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WITHDRAWN: A Review of Optimization Methods for Production and Injection Well Placement in Hydrocarbon Reservoirs

Nikravesh,

Ranjbar,

Zohre Nikravesh

2024

Heliyon

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Dynamic synthetic-scanning photoacoustic tracking monitors hepatic and renal clearance pathway of exogeneous probes in vivo

Lv,

Lan,

Qin

et al. 2024

Light Sci Appl

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Advancements in precision medicine necessitate understanding drug clearance pathways, especially in organs like the liver and kidneys. Traditional techniques such as PET/CT pose radiation hazards, whereas optical imaging poses challenges in maintaining both depth penetration and high resolution. Moreover, very few longitudinal studies have been performed for drug candidates for different symptoms. Leveraging non-ionizing photoacoustic tomography for deep tissue imaging, we developed a spatiotemporally resolved clearance pathway tracking (SRCPT) method, providing unprecedented insights into drug clearance dynamics within vital organs. SRCPT addresses challenges like laser fluence attenuation, enabling dynamic visualization of drug clearance pathways and essential parameter extraction. We employed a novel frequency component selection based synthetic aperture focusing technique (FCS-SAFT) with respiratory-artifacts-free weighting factors to enhance three-dimensional imaging resolutions. Inspired by this, we investigated the clearance pathway of a clinical drug, mitoxantrone, revealing reduced liver clearance when hepatic function is impaired. Furthermore, immunoglobulin G clearance analysis revealed significant differences among mice with varying renal injury degrees. The accuracy of our method was validated using a double-labeled probe [68Ga]DFO-IRDye800CW, showing a strong positive correlation between SRCPT and PET. We believe that this powerful SRCPT promises precise mapping of drug clearance pathways and enhances diagnosis and treatment of liver and kidney-related diseases.

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Restoring the imaging quality of circular transducer array-based PACT using synthetic aperture focusing technique integrated with 2nd-derivative-based back projection scheme

Cited by 6 publications

References 41 publications

Influence mechanism of the temporal duration of laser irradiation on photoacoustic technique: a review

Influence mechanism of the temporal duration of laser irradiation on photoacoustic technique: a review

WITHDRAWN: A Review of Optimization Methods for Production and Injection Well Placement in Hydrocarbon Reservoirs

Dynamic synthetic-scanning photoacoustic tracking monitors hepatic and renal clearance pathway of exogeneous probes in vivo

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