Restrained eating is associated with low leptin levels in underweight females

Prittwitz, S von; Blum, Werner; Ziegler, Andreas; Scharmann, S; Remschmidt, Helmut; Hebebrand, Johannes

doi:10.1038/sj.mp.4000300

Cited by 42 publications

(22 citation statements)

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“…9,10,27,28 Furthermore, the results do not support the hypothesis that in eating disordered and in BED patients a low serum leptin concentration is a primary phenomenon, which causes a restriction of food intake in anorexia nervosa patients, 27 or an increased hunger sensation that compels bulimia nervosa or BED patients to binge. 29 Rather, increased or decreased serum leptin concentrations merely seem to be the consequence of prolonged periods of sharply negative energy balance ensuing from frequent dieting in anorectic patients or in restricting individuals, or of frequent bouts of positive energy balances due to bingeing episodes in BED and in bulimic patients.…”

Section: Discussioncontrasting

confidence: 52%

“…9,10,27,28 In contrast, this study showed that serum leptin concentration was positively related only to scores indicating a tendency to lose control over food intake. This would suggest that the dietary restraint of severely obese patients is inadequate in reducing the current food intake and therefore plays no role in influencing leptin concentration.…”

Section: Discussioncontrasting

confidence: 48%

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Serum leptin concentration in obese patients with binge eating disorder

Adami

Campostano²,

Cella

et al. 2002

Int J Obes

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BACKGROUND:In steady-state conditions serum leptin concentration is directly related to body fat stores, but is also affected by changes in energy balance. This cross-sectional study investigated the serum leptin concentrations of severely obese patients with binge eating disorder (BED), in whom body fat was greater than normal and, because of eating pattern, rapid and repeated changes in energy balances took place. METHODS: A group of BED obese patients was compared to a group of obese patients with a regular eating pattern with the same body weight, body composition and resting energy expenditure. Serum leptin was measured and the eating attitudes were evaluated by Eating Inventory and Eating Disorder Inventory. RESULTS: In these patients serum leptin concentrations were only weakly correlated to body mass. Furthermore, in BED obese patients serum leptin concentration was higher than in their non bingeing counterparts. CONCLUSIONS: In obese patients both body fat size and eating behavior influence serum leptin concentration, but BED patients binge eating is not triggered by a low leptin value.

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Section: Discussioncontrasting

confidence: 52%

Section: Discussioncontrasting

confidence: 48%

Serum leptin concentration in obese patients with binge eating disorder

Adami

Campostano²,

Cella

et al. 2002

Int J Obes

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“…First, in over 400 male and female students with a BMI below 85% average body weight, most individuals were healthy 27,28 (Hebebrand et al, unpublished data) and tracking of BMI in adulthood 29 implies that many lean young adults will remain so over time. These individuals can also expect a longer life span than those with higher body weight.…”

Section: Anorexia Nervosamentioning

confidence: 99%

“…26 Fourth, serum leptin levels also differentiate between constitutionally lean females and those with AN. 27,28 Fifth, initially at least, weight loss in AN is usually voluntary, and although intentional weight loss is moderately heritable, the majority of genetic factors affecting BMI are different from those affecting intentional weight loss. 35 Molecular genetic studies that incorporated relevant covariates into linkage analyses have included the related construct of minimum BMI, a variable that more closely approximates the core phenotype of AN as it indexes the extreme low BMI values reached as the body experiences a complete failure to regulate weight.…”

Section: Anorexia Nervosamentioning

confidence: 99%

Genetic epidemiology, endophenotypes, and eating disorder classification

Bulik

Keski‐Rahkonen

Klump

et al. 2007

Int. J. Eat. Disord.

121

111

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Objective: To explore how genetic epidemiology has informed the identification of endophenotypes and how endophenotypes may inform future classification of eating disorders.Method: Literature review and synthesis.Results: Although a number of endoand subphenotypes have been suggested for eating disorders, few reach the rigorous definitions developed for candidate endophenotypes. Conclusion:Further study of endophenotypes and subphenotypes for eating disorders may assist with developing a more homogenous classification system that more closely reflects underlying biological mechanisms, and provides a clearer focus for the development of coherent models and treatments. V V C 2007 by Wiley Periodicals, Inc.

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“…20,23 The relationship between dietary restraint and endogenous leptin levels has been studied in overweight women, but no significant correlation was found. 24,25 To our knowledge, this relationship has not yet been investigated in overweight men. The question remains whether pharmacological treatment, that is, PEG-OB protein treatment, replaces or supports an increase of dietary restraint during treatment.…”

Section: Introductionmentioning

confidence: 98%

Effect of dietary restraint during and following pegylated recombinant leptin (PEG-OB) treatment of overweight men

et al. 2003

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OBJECTIVE:To examine the effect of dietary restraint during and following pegylated recombinant leptin (PEG-OB protein) treatment in overweight men. DESIGN: A randomized double-blind placebo-controlled trial in 24 overweight men (BMI: 28.870.3 kg/m 2 ; age: 34.870.9 y). PEG-OB protein (80 mg) or placebo was administered subcutaneously weekly for 6 weeks, combined with a 2.1 MJ/day energy restriction program. Dietary restraint was determined by the Three-Factor Eating Questionnaire before and after treatment, and after 8 weeks follow-up. RESULTS: During treatment dietary restraint increased, and general hunger, resting energy expenditure and respiratory quotient decreased similarly in the PEG-OB and the placebo group. With PEG-OB treatment, additional weight loss (Po0.03) was observed. During 8 weeks follow-up, body weight increase was larger in the PEG-OB group compared to placebo (Po0.05), and body weight regain was faster. Body weight regain was inversely correlated with the increase in cognitive dietary restraint during treatment (PEG-OB group: r 2 ¼ 0.49, Po0.02; placebo group: r 2 ¼ 0.60, P ¼ 0.01). CONCLUSION: Although treatment with PEG-OB protein led to a greater body weight loss relative to placebo, weight maintenance thereafter was mainly supported by dietary restraint, which was more effective in the placebo-treated group, resulting in a slower regain of body weight.

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Restrained eating is associated with low leptin levels in underweight females

Cited by 42 publications

References 0 publications

Serum leptin concentration in obese patients with binge eating disorder

Serum leptin concentration in obese patients with binge eating disorder

Genetic epidemiology, endophenotypes, and eating disorder classification

Effect of dietary restraint during and following pegylated recombinant leptin (PEG-OB) treatment of overweight men

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