Restraint Stress Slows Cutaneous Wound Healing in Mice

Padgett, David A.; Marucha, Phillip T.; Sheridan, John F.

doi:10.1006/brbi.1997.0512

Cited by 238 publications

(222 citation statements)

References 14 publications

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“…This converges with other findings suggesting that psychosocial stress has a causal link to the impaired wound healing associated with it (Padgett, Marucha et al 1998;Detillion, Craft et al 2004;Sheridan, Padgett et al 2004;Glasper and Devries 2005;Horan, Quan et al 2005;Eijkelkamp, Engeland et al 2007). …”

Section: Relation Between Isolation Rearing and Impaired Wound Healingsupporting

confidence: 90%

“…In addition, isolation rearing has been found to impair wound healing (Detillion, Craft et al 2004;Glasper and Devries 2005). Other animal models of psychological stress, particularly restraint stress, impair wound healing (Padgett, Marucha et al 1998;Sheridan, Padgett et al 2004;Horan, Quan et al 2005;Eijkelkamp, Engeland et al 2007), although interestingly, the social intruder model of stress did not affect wound healing (Sheridan, Padgett et al 2004). …”

Section: Introductionmentioning

confidence: 99%

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Isolation rearing impairs wound healing and is associated with increased locomotion and decreased immediate early gene expression in the medial prefrontal cortex of juvenile rats

Levine¹,

Leeder²,

Parekkadan³

et al. 2008

Neuroscience

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In addition to its maladaptive effects on psychiatric function, psychosocial deprivation impairs recovery from physical illness. Previously, we found that psychosocial deprivation, modeled by isolation rearing, depressed immediate early gene (IEG) expression in the medial prefrontal cortex (mPFC) and increased locomotion in the open field test (Levine, Youngs et al. 2007). In the present study, we examined whether similar changes in behavior and gene expression are associated with the maladaptive effects of psychosocial deprivation on physical injury healing. After weaning, anesthetized rats were subjected to a 20% total body surface area third degree burn injury and were subsequently either group or isolation reared. After four weeks of either isolation or group rearing (a period that encompasses rodent childhood and early adolescence), rats were sacrificed, and their healing and gene expression in the mPFC were assessed. Locomotion in the open field test was examined at 3 weeks post burn injury. We found that: 1) gross wound healing was significantly impaired in isolation reared rats compared to group reared rats, 2) locomotion was increased and IEG expression was suppressed for isolation reared rats during burn injury healing, 3) the decreased activity in the open field and increased IEG expression was greater for burn injury healing group reared rats than for uninjured group reared rats, 4) the degree of hyperactivity and IEG suppression was relatively similar between isolation reared rats during burn injury compared to uninjured isolation reared rats, 5) behavioral hyperactivity to novelty (the open

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Section: Relation Between Isolation Rearing and Impaired Wound Healingsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Isolation rearing impairs wound healing and is associated with increased locomotion and decreased immediate early gene expression in the medial prefrontal cortex of juvenile rats

Levine¹,

Leeder²,

Parekkadan³

et al. 2008

Neuroscience

View full text Add to dashboard Cite

show abstract

“…Endotoxin injection on as few as two occasions in the first week of life has been shown to exacerbate responses to stress much later in the mature animal, including HPA axis activation indicators (Hodgson et al, 2000;Shanks, Larocque, & Meaney, 1995), stressinduced suppression of lymphocyte proliferative responses (Shanks et al, 2000), and increased susceptibility to the metastasis of NK-sensitive MADB106 tumor cells (Hodgson et al, 2000). Neonatal endotoxin injection in rats has also been shown to result in delayed wound healing in the mature animal (Hodgson et al, 2000), which reflects the animals' inability to mount an inflammatory response (Padgett, Marucha, & Sheridan, 1998). The results are consistent with the findings of Shanks and colleagues (2000) that neonatal endotoxin-treated animals did not exhibit the expected increase in paw volume following induction of adjuvant arthritis.…”

Section: Influences Of Endotoxin As the Stressor In Rat Studiessupporting

confidence: 65%

Are There Long-Term Consequences of Pain in Newborn or Very Young Infants?

Page

2004

jpe

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Physiologic studies indicate that very early pain or stress experiences have more than immediate consequences for infants. Assessment and care of pain are complex subjects made even more complex and challenging when the individual experiencing pain is a very young infant. This review provides evidence that significant and long-lasting physiological consequences may follow painful insults in the very young, including changes in the central nervous system and changes in responsiveness of the neuroendocrine and immune systems to stress at maturity.Journal of Perinatal Education, 13(3), 10e17; pain, premature infant, newborn, stress, physiological development.

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“…Although the antiinflammatory activity of Gc, especially at pharmacological levels, may help reduce inflammatory reactions and thus avert tissue damage, prolonged Gc exposure can lead to a variety of unwanted side effects, including immunosuppression (2,3). Indeed, both exogenous (4) and endogenous (5) Gc have immunosuppressive effects, including inhibition of MHC class II expression (6), disruption of Th1/Th2 balance (7), and increased susceptibility to infection during wound healing (8,9).…”

mentioning

confidence: 99%

Natural glucocorticoids induce expansion of all developmental stages of murine bone marrow granulocytes without inhibiting function

Trottier

Newsted

King

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

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Natural glucocorticoids (Gc) produced during stress have profound effects on the immune system. It is well known that Gc induce apoptosis in precursor T and B cells, markedly altering lymphopoiesis. However, it has been noted that marrow myeloid cells expanded both in proportion and absolute numbers in the mouse after Gc exposure. Mice were implanted with a corticosterone (CS) tablet that increased serum Gc and caused atrophied thymuses, both classic signs of activation of the stress axis. Blood neutrophil counts were elevated (4.8؋), whereas lymphocyte counts declined. Flow cytometric analysis of the marrow revealed that the phenotypic distribution of the various major classes of cells was shifted by Gc exposure. As expected, marrow lymphocyte numbers declined >40% after 3 days of exposure to Gc. Conversely, in the myeloid compartment, both monocytes and granulocytes increased in number by >40%. Further, all granulocyte developmental stages showed large increases in both total number and percentage of cells. To investigate the functional capacity of mature granulocytes from Gc-treated mice, an improved granulocyte isolation method was developed. Gc exposure had little effect on the ability of granulocytes to produce superoxide or undergo chemotaxis or phagocytose bacteria. These results indicate that Gc treatment shifts bone marrow composition and provides evidence that granulocytes and their progenitors are selectively preserved under stressful conditions without losing function.granulopoiesis ͉ lymphopoiesis

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Restraint Stress Slows Cutaneous Wound Healing in Mice

Cited by 238 publications

References 14 publications

Isolation rearing impairs wound healing and is associated with increased locomotion and decreased immediate early gene expression in the medial prefrontal cortex of juvenile rats

Isolation rearing impairs wound healing and is associated with increased locomotion and decreased immediate early gene expression in the medial prefrontal cortex of juvenile rats

Are There Long-Term Consequences of Pain in Newborn or Very Young Infants?

Natural glucocorticoids induce expansion of all developmental stages of murine bone marrow granulocytes without inhibiting function

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