Restricted feeding for 9 h in the active period partially abrogates the detrimental metabolic effects of a Western diet with liquid sugar consumption in mice

Woodie, Lauren N.; Luo, Yuqi; Wayne, Michael J.; Graff, Emily C.; Ahmed, Bulbul; O’Neill, Ann Marie; Greene, Michael W.

doi:10.1016/j.metabol.2017.12.004

Cited by 69 publications

(59 citation statements)

References 45 publications

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“…This is supported by several studies in which TRF has been found to enhance lipid oxidation over lipogenesis [8,12,21,55]. Indeed, TRF has been shown to reduce hepatic expression of PPARγ and SREBF1, the key lipogenic genes, in HFD-fed rats [55]. In addition, TRF regimen reduced lipid droplet associated and lipolysis inhibitor gene Cidec expressions, TG storage-associated protein CD36, and plasma TG marker ApoA 4 in HFD-fed mice [8].Decreased TG in the liver results in reduced serum levels of LDL and very-low-density lipoprotein (VLDL), leading to loss of transported cholesterol and TG within them [54].…”

Section: Discussionsupporting

confidence: 58%

“…Since the liver is a central organ in lipid metabolism, we suggest that the beneficial effect of a TRF regimen on lipid profiles in CAF-fed ratsmay be due to the enhancement of hepatic lipid metabolism. This is supported by several studies in which TRF has been found to enhance lipid oxidation over lipogenesis [8,12,21,55]. Indeed, TRF has been shown to reduce hepatic expression of PPARγ and SREBF1, the key lipogenic genes, in HFD-fed rats [55].…”

Section: Discussionmentioning

confidence: 73%

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Time-Restricted Feeding Improves Body Weight Gain, Lipid Profiles, and Atherogenic Indices in Cafeteria-Diet-Fed Rats: Role of Browning of Inguinal White Adipose Tissue

et al. 2020

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Time-restricted feeding (TRF) showed a potent effect in preventing obesity and improving metabolicoutcomes in several animal models of obesity. However, there is, as of yet, scarce evidence concerning its effectiveness against obesogenic challenges that more accurately mimic human Western diets, such as the cafeteria diet. Moreover, the mechanism for its efficacy is poorly understood. White adipose browning has been linked to body weight loss. Herein, we tested whether TRF has the potential to induce browning of inguinal white adipose tissue (iWAT) and to attenuate obesity and associated dyslipidemia in a cafeteria-diet-induced obesity model. Male Wistar rats were fed normal laboratory chow (NC) or cafeteria diet (CAF) for 16 weeks and were subdivided into two groups that were subjected to either ad libitum (ad lib, A) or TRF (R) for 8 h per day. Rats under the TRF regimen had a lower body weight gain and adiposity than the diet-matchedad lib rats, despite equivalent levels of food intake and locomotor activity. In addition, TRF improved the deranged lipid profile (total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL-c), low-density lipoprotein (LDL-c)) and atherogenic indices (atherogenic index of plasma (AIP), atherogenic coefficient (AC), coronary risk index (CRI) in CAF-fed rats. Remarkably, TRF resulted in decreased size of adipocytes and induced emergence of multilocular brown-like adipocytes in iWAT of NC- and CAF-fed rats. Protein expression of browning markers, such as uncoupling protein-1 (UCP1) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α), were also up-regulated in the iWAToftime-restricted NC- or CAF-fed rats. These findings suggest that a TRF regimen is an effective strategy to improve CAF diet-induced obesity, probably via a mechanismthe involving WAT browning process.

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 73%

Time-Restricted Feeding Improves Body Weight Gain, Lipid Profiles, and Atherogenic Indices in Cafeteria-Diet-Fed Rats: Role of Browning of Inguinal White Adipose Tissue

et al. 2020

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“…In rodents, extending the duration of fasting improves glycemic control and reduces the incidence of cardiovascular disease 3 . Time-restricted feeding (TRF), typically defined as food consumed for <10 h per day, represents a practical means to control dietary intake by extending the time spent fasting and improves markers of metabolic health in both animal models 4 – 7 and humans 8 . In rodents fed a high-fat diet, TRF attenuates body weight gain, reduces body fat accumulation, improves glucose tolerance, and restores diurnal rhythms of core clock transcripts compared to high-fat ad libitum diets 4 , 9 .…”

Section: Introductionmentioning

confidence: 99%

Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression

et al. 2020

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Time-restricted feeding (TRF) improves metabolism independent of dietary macronutrient composition or energy restriction. To elucidate mechanisms underpinning the effects of short-term TRF, we investigated skeletal muscle and serum metabolic and transcriptomic profiles from 11 men with overweight/obesity after TRF (8 h day−1) and extended feeding (EXF, 15 h day−1) in a randomised cross-over design (trial registration: ACTRN12617000165381). Here we show that muscle core clock gene expression was similar after both interventions. TRF increases the amplitude of oscillating muscle transcripts, but not muscle or serum metabolites. In muscle, TRF induces rhythmicity of several amino acid transporter genes and metabolites. In serum, lipids are the largest class of periodic metabolites, while the majority of phase-shifted metabolites are amino acid related. In conclusion, short-term TRF in overweight men affects the rhythmicity of serum and muscle metabolites and regulates the rhythmicity of genes controlling amino acid transport, without perturbing core clock gene expression.

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“…Restricting food intake to the resting phase worsened fasting and postprandial glucose concentrations, blood pressure, and lipid concentrations in humans [32,136], and induced leptin resistance that contributes to the development of obesity and metabolic disorders in mice [137]. However, restricting food intake to the active phase improved insulin sensitivity, blood pressure, glucose tolerance, and oxidative stress [8,138,139].…”

Section: Discussionmentioning

confidence: 99%

Intermittent Fasting for Twelve Weeks Leads to Increases in Fat Mass and Hyperinsulinemia in Young Female Wistar Rats

et al. 2020

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Fasting is known to cause physiological changes in the endocrine pancreas, including decreased insulin secretion and increased reactive oxygen species (ROS) production. However, there is no consensus about the long-term effects of intermittent fasting (IF), which can involve up to 24 hours of fasting interspersed with normal feeding days. In the present study, we analyzed the effects of alternate-day IF for 12 weeks in a developing and healthy organism. Female 30-day-old Wistar rats were randomly divided into two groups: control, with free access to standard rodent chow; and IF, subjected to 24-hour fasts intercalated with 24-hours of free access to the same chow. Alternate-day IF decreased weight gain and food intake. Surprisingly, IF also elevated plasma insulin concentrations, both at baseline and after glucose administration collected during oGTT. After 12 weeks of dietary intervention, pancreatic islets displayed increased ROS production and apoptosis. Despite their lower body weight, IF animals had increased fat reserves and decreased muscle mass. Taken together, these findings suggest that alternate-day IF promote β -cell dysfunction, especially in developing animals. More long-term research is necessary to define the best IF protocol to reduce side effects.

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Restricted feeding for 9 h in the active period partially abrogates the detrimental metabolic effects of a Western diet with liquid sugar consumption in mice

Cited by 69 publications

References 45 publications

Time-Restricted Feeding Improves Body Weight Gain, Lipid Profiles, and Atherogenic Indices in Cafeteria-Diet-Fed Rats: Role of Browning of Inguinal White Adipose Tissue

Time-Restricted Feeding Improves Body Weight Gain, Lipid Profiles, and Atherogenic Indices in Cafeteria-Diet-Fed Rats: Role of Browning of Inguinal White Adipose Tissue

Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression

Intermittent Fasting for Twelve Weeks Leads to Increases in Fat Mass and Hyperinsulinemia in Young Female Wistar Rats

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