Restricted, Repetitive, and Reciprocal Social Behavior in Toddlers Born Small for Gestation Duration

Sifre, Robin; Lasch, Carolyn; Fenoglio, Angela; Georgieff, Michael; Wolff, Jason J.; Elison, Jed T.

doi:10.1016/j.jpeds.2018.05.003

Cited by 6 publications

(8 citation statements)

References 25 publications

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“…University of Minnesota Institute of Child Development (ICD) sample. As previously reported (Sifre et al, 2018), between May 2015 and July 2016, parents of toddlers aged 17–26 months were recruited from the University of Minnesota ICD research participant registry. Parents were initially identified from Minnesota birth records and invited to join the registry voluntarily.…”

Section: Methodsmentioning

confidence: 99%

“…To more closely match the age of this cohort with both the initial 18-month assessment in the Early Reciprocal Social Behavior Study (ERSB, see below) and the age of the video-scoring anchor used in the vrRSB, data from children aged 17.0–21.9 months were retained for analyses, resulting in a final total of 1,563 participants, comprising 1,549 singletons and seven twin pairs (six pairs of non-Hispanic ethnicity and six pairs of Caucasian race). Participants reflected the racial/ethnic composition of Minneapolis but showed less socioeconomic diversity (Sifre et al, 2018). Study procedures were approved by the University of Minnesota Human Research Protection Program and Institutional Review Board and parents provided informed consent and permission for their child's participation.…”

Section: Methodsmentioning

confidence: 99%

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Genetic architecture of reciprocal social behavior in toddlers: Implications for heterogeneity in the early origins of autism spectrum disorder

et al. 2020

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Impairment in reciprocal social behavior (RSB), an essential component of early social competence, clinically defines autism spectrum disorder (ASD). However, the behavioral and genetic architecture of RSB in toddlerhood, when ASD first emerges, has not been fully characterized. We analyzed data from a quantitative video-referenced rating of RSB (vrRSB) in two toddler samples: a community-based volunteer research registry (n = 1,563) and an ethnically diverse, longitudinal twin sample ascertained from two state birth registries (n = 714). Variation in RSB was continuously distributed, temporally stable, significantly associated with ASD risk at age 18 months, and only modestly explained by sociodemographic and medical factors (r2 = 9.4%). Five latent RSB factors were identified and corresponded to aspects of social communication or restricted repetitive behaviors, the two core ASD symptom domains. Quantitative genetic analyses indicated substantial heritability for all factors at age 24 months (h2 ≥ .61). Genetic influences strongly overlapped across all factors, with a social motivation factor showing evidence of newly-emerging genetic influences between the ages of 18 and 24 months. RSB constitutes a heritable, trait-like competency whose factorial and genetic structure is generalized across diverse populations, demonstrating its role as an early, enduring dimension of inherited variation in human social behavior. Substantially overlapping RSB domains, measurable when core ASD features arise and consolidate, may serve as markers of specific pathways to autism and anchors to inform determinants of autism's heterogeneity.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Genetic architecture of reciprocal social behavior in toddlers: Implications for heterogeneity in the early origins of autism spectrum disorder

et al. 2020

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“…In one study ( n = 146, including 76 females; average age at time point 1 = 21.04 ( SD = 2.67) months), drawn from a much larger sample (cf. Sifre et al, 2018), the only inclusion criterion was age between 17 and 26 months, although no twins were included. In the second study ( n = 59, including 33 females; average age at time point 1 = 18.21 ( SD = 0.26) months), the following exclusion criteria were used: major pregnancy or birth complications, gestational age less than 37 weeks, birthweight less than 2000 grams, or the presence of genetic, neurological, or medical problems affecting cognition.…”

Section: Methodsmentioning

confidence: 99%

Examining criterion-oriented validity of the Repetitive Behavior Scales for Early Childhood (RBS-EC) and the Video-Referenced Rating of Reciprocal Social Behavior (vrRSB)

Lasch

Wolff

Elison³

2019

Dev Psychopathol

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Improved characterization of quantitative traits and dimensionally distributed complex behaviors during toddlerhood may improve early identification of autism spectrum disorder and related neurodevelopmental disorders. Parents of 205 community-ascertained toddlers (age: mean = 20.2, SD = 2.6 months) completed the Repetitive Behavior Scales for Early Childhood (RBS-EC) and the Video-Referenced Rating of Reciprocal Social Behavior (vrRSB), with longitudinal follow-up of behavioral assessments and/or another round of parent-report questionnaires. Criterion validity was examined both concurrently and longitudinally using the Infant Toddler Social Emotional Assessment (ITSEA) as a criterion anchor. Reciprocal social behavior as measured by the vrRSB was significantly associated with social competence as measured by the ITSEA, longitudinally and concurrently. Reciprocal social behavior was not associated with the externalizing subscale on the ITSEA, providing evidence of discriminant validity. Higher-order repetitive behaviors (restricted interests; rituals and routines) as measured by RBS-EC subscales were associated with the dysregulation and internalizing subscales of the ITSEA, longitudinally and concurrently. All RBS-EC subscales (excepting repetitive motor) were associated concurrently and longitudinally with the dysregulation subscale of the ITSEA. We report evidence of criterion-oriented and discriminant validity for the constructs/domains captured by the RBS-EC and vrRSB. These instruments may be particularly useful in characterizing dimensional variability across the typical-to-atypical continuum.

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“…The Repetitive Behavior Scale for Early Childhood (RBS-EC [56]) is a 34-item parent-report questionnaire that is a downward extension of the Repetitive Behavior Scale-Revised (RBS-R [7]), with good-to-excellent psychometric properties and evidence of validity and reliability (based on an independent sample of toddlers). The questionnaire is intended to capture normative variation in young children that spans across the typical-to-atypical continuum and has been used to detect difference in RRBs as a function of birthweight percentile [46], and to detect associations between RRBs and dysregulation and internalizing symptoms [30] in toddlers. For distributions of RBS-EC scores in the present sample, see Figure S1 in the Online Supplement.…”

Section: Repetitive Behavior Scale For Early Childhoodmentioning

confidence: 99%

Longitudinal change in restricted and repetitive behaviors from 8-36 months

Sifre

Berry

Wolff

et al. 2021

J Neurodevelop Disord

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Background Restricted and repetitive behaviors (RRBs) are core features of autism spectrum disorder (ASD) and one of the earliest behavioral signs of ASD. However, RRBs are also present in typically developing (TD) infants, toddlers, and preschool-aged children. Past work suggests that examining change in these behaviors over time is essential to distinguish between normative manifestations of these behaviors and behaviors that denote risk for a neurodevelopmental disorder. One challenge in examining changes in these behaviors over time is that most measures of RRBs have not established longitudinal measurement invariance. The aims of this study were to (1) establish measurement invariance in the Repetitive Behavior Scales for Early Childhood (RBS-EC), a parent-report questionnaire of RRBs, and (2) model developmental change in RRBs from 8 to 36 months. Methods We collected RBS-EC responses from parents of TD infants (n = 180) from 8 to 36 months (n = 606 responses, with participants contributing an average of 3-time points). We leverage a novel methodological approach to measurement invariance testing (Bauer, Psychological Models, 22(3), 507–526, 2017), moderated nonlinear factor analysis (MNLFA), to determine whether the RBS-EC was invariant across age and sex. We then generated adjusted factor score estimates for each subscale of the RBS-EC (repetitive motor, self-directed, and higher-order behaviors), and used linear mixed effects models to estimate between- and within-person changes in the RBS-EC over time. Results The RBS-EC showed some non-invariance as a function of age. We were able to adjust for this non-invariance in order to more accurately model changes in the RBS-EC over time. Repetitive motor and self-directed behaviors showed a linear decline from 8 to 36 months, while higher-order behaviors showed a quadratic trajectory such that they began to decline later in development at around 18 months. Using adjusted factor scores as opposed to unadjusted raw mean scores provided a number of benefits, including increased within-person variability and precision. Conclusions The RBS-EC is sensitive enough to measure the presence of RRBs in a TD sample, as well as their decline with age. Using factor score estimates of each subscale adjusted for non-invariance allowed us to more precisely estimate change in these behaviors over time.

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Restricted, Repetitive, and Reciprocal Social Behavior in Toddlers Born Small for Gestation Duration

Cited by 6 publications

References 25 publications

Genetic architecture of reciprocal social behavior in toddlers: Implications for heterogeneity in the early origins of autism spectrum disorder

Genetic architecture of reciprocal social behavior in toddlers: Implications for heterogeneity in the early origins of autism spectrum disorder

Examining criterion-oriented validity of the Repetitive Behavior Scales for Early Childhood (RBS-EC) and the Video-Referenced Rating of Reciprocal Social Behavior (vrRSB)

Longitudinal change in restricted and repetitive behaviors from 8-36 months

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