Restricted Usage of T-Cell Receptor Vα-Vβ Genes in Infiltrating Cells in Aortic Tissue of Patients With Takayasu’s Arteritis

Seko, Yoshinori; Satō, Osamu; Takagi, Akio; Tada, Yusuke; Matsuo, Hiroshi; Yagita, Hideo; Okumura, Ko; Yazaki, Yoshio

doi:10.1161/01.cir.93.10.1788

Cited by 106 publications

(54 citation statements)

References 5 publications

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“…58 Serum levels of IL-6 have also been shown to correlate with disease activity. 59 Abisror et al have done a review of the existing literature by pooling 44 adult TA patients on tocilizumab (TCZ) with the majority receiving 8 mg/kg/month.…”

Section: Biological Therapy In Tamentioning

confidence: 99%

Childhood‐onset Takayasu arteritis: an update

et al. 2015

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Childhood-onset Takayasu arteritis (c-TA) is a distinct subset affecting a wide age group, ranging from young infants to adolescents and it differs from adult TA in many aspects. There is scarcity of data on c-TA worldwide. The disease is classified using the European League Against Rheumatism/Pediatric Rheumatology International Trials Organization/Pediatric Rheumatology European Society criteria. The non-specific nature of presenting complaints and lack of appropriate biomarkers delay the early diagnosis of this illness and many children present with complications, which become irreversible once they set in. One of the largest cohorts of 40 children with c-TA from our center reports hypertension as the commonest presenting feature. Systemic symptoms like headache, fever and weight loss are also described. Assessment of disease in c-TA is done by correlating clinical features with raised inflammatory markers. Advanced imaging plays an important role in diagnosis. In c-TA, the role of magnetic resonance angiography is advocated, taking into consideration the enormous amount of radiation exposure with other modalities. Complications of c-TA include cardiovascular, pulmonary, neurological and those arising secondary to long-term steroid and immunosuppression therapy.

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Section: Biological Therapy In Tamentioning

confidence: 99%

Childhood‐onset Takayasu arteritis: an update

et al. 2015

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“…On the other hand, strong expression of IL-6 has been shown to occur in the aortic tissue of patients with TA (6). Serum IL-6 levels have been reported to be greatly elevated in patients with TA and to correlate positively with disease activity (4,6,7).…”

mentioning

confidence: 99%

Successful treatment of a patient with takayasu arteritis using a humanized anti–interleukin‐6 receptor antibody

Nishimoto

Nakahara

Yoshio-Hoshino

et al. 2008

Arthritis & Rheumatism

168

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Takayasu arteritis (TA) is a chronic inflammatory disease that involves the aorta and its major branches. Since overproduction of interleukin-6 (IL-6) seems to play a pathogenic role in TA, we used the anti-IL-6 receptor (IL-6R) antibody tocilizumab to treat a 20-year-old woman with refractory active TA complicated by ulcerative colitis (UC). Treatment with tocilizumab improved the clinical manifestations of TA and the abnormal laboratory findings in this patient and ameliorated the activity of UC. These results indicate that IL-6R inhibition with tocilizumab might be a future treatment option for TA.

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“…To investigate the roles of αβ T-cells in the immunopathology in Takayasu arteritis, especially to determine whether αβ T-cells specifically infiltrated the aortic tissue, we analyzed TCR Vα and Vβ gene usage in infiltrating cells in the aortic tissue with Takayasu arteritis as well as atherosclerotic aortic aneurysm by a reverse transcription-polymerase chain reaction (RT-PCR) method. 25) We found that almost all TCR Vα as well as Vβ genes were expressed in peripheral blood lymphocytes with Takayasu arteritis and in infiltrating cells in the aortic tissue with atherosclerotic aortic aneurysm. In sharp contrast, only a few or limited number of Vα as well as Vβ genes were preferentially rearranged and transcribed in infiltrating cells in the aortic tissue with Takayasu arteritis.…”

Section: Roles Of αβ T-cells In the Immunopathology In Takayasu Artermentioning

confidence: 77%

“…presented by HLAs may occur, as we previously reported. 8,25) The expression of HSP-65 in vascular (smooth muscle) cells may play a role in the induction of MICA expression. It seems that γδ T-cells (unlike αβ T-cells) recognize small nonpeptidic antigens without antigen processing and presentation.…”

Section: Roles Of Genetic Factors In the Immunopathology In Takayasu mentioning

confidence: 99%

Takayasu Arteritis. Insights into Immunopathology.

Seko

2000

Jpn Heart J

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Yoshinori SEKO, MD T AKAYASU arteritis is a chronic form of vasculitis characteristic of stenotic and occasionally dilated lesions in the aorta, its main branches, pulmonary From the Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.Address for correspondence: Yoshinori Seko, MD, Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.Received for publication December 3, 1999. Accepted December 10, 1999. SUMMARYTakayasu arteritis is an acute and sometimes chronic form of vasculitis involving the aorta, its main branches and pulmonary arteries. Although its etiology is still unknown, immunopathologic analyses revealed that the infiltrating cells mainly consisted of γδ T-cells as well as αβ T-cells and NK cells. The infiltrating γδ T-cells, cytotoxic T-lymphocytes (CTLs), and natural killer (NK) cells directly injured the vascular cells by releasing a cytolytic factor, perforin. Expression of heat-shock protein (HSP)-65 as well as human leukocyte antigen (HLA) class I and II was enhanced in Takayasu arteritis lesions, supporting the pathogenic role of γδ T-cells and αβ T-cells. T-cell receptor (TCR) αβ gene usage by the infiltrating cells was restricted, strongly suggesting that a specific antigen was targeted. TCR γδ gene usage by the infiltrating cells was also restricted. Furthermore, it has been reported that a strong association with a specific haplotype of major histocompatibility complex (MHC) class I chain-related (MIC), MICA gene with Takayasu arteritis, suggesting that the HLA-linked gene susceptible to the disease is mapped near the MICA gene. This also supports a pathogenic role of γδ T-cells in Takayasu arteritis because γδ T-cells were shown to recognize MICA molecule, which can be stress-induced. These findings suggest that unknown stress, such as infection, may trigger the autoimmune process of inflammation involved in Takayasu arteritis. Jpn Heart J 2000; 41: 15-26)

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Restricted Usage of T-Cell Receptor Vα-Vβ Genes in Infiltrating Cells in Aortic Tissue of Patients With Takayasu’s Arteritis

Cited by 106 publications

References 5 publications

Childhood‐onset Takayasu arteritis: an update

Childhood‐onset Takayasu arteritis: an update

Successful treatment of a patient with takayasu arteritis using a humanized anti–interleukin‐6 receptor antibody

Takayasu Arteritis. Insights into Immunopathology.

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