Restricting Molecular Mobility in Polymer Nanocomposites with Self-Assembling Low-Molecular-Weight Gel Additives

Alexander, Symone; Korley, LaShanda T. J.

doi:10.1021/acsami.8b15112

Cited by 7 publications

(4 citation statements)

References 21 publications

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“…We assume that the increased number of physical bonds ( e.g. , hydrogen bonds between ether bonds or terminated hydroxyl in mPEG-(OH) 1 and hydroxyl groups in peptide hydrogelators) between mPEG-(OH) 1 molecules and peptide hydrogelators leads to the sharp decrease of the CGC for mPEG-(OH) 1 samples with nearly no entanglements . As for entangled mPEG-(OH) 1 samples, the increased number of entanglements may dominate the change of CGC .…”

Section: Resultsmentioning

confidence: 99%

Hybrid Hydrogels from Nongelling Polymers Using a Fibrous Peptide Hydrogelator at Low Concentrations

Wei

Lin

et al. 2022

Langmuir

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Nature-made hydrogels typically combine a wide range of multiscale fibers into biological composite networks, which offer an adaptive property. Inspired by nature, we report a facile approach to construct hybrid hydrogels from a range of natural or commercially available synthetic nongelling polymers (e.g., poly(ethylene glycol), poly(acrylic acid), carboxylated cellulose nanocrystal, and sodium alginate) at a concentration as low as 0.53 wt % using a nonionic fibrous peptide hydrogelator. Through simply mixing the peptide hydrogelator with a polymer aqueous solution, stable hybrid hydrogels can be formed with the concentration of hydrogelator at ∼0.05 wt %. The gel strength of the resulting hydrogels can be effectively modulated by the concentration, molecular weight, and terminal group of the polymer. We further demonstrate that the molecular interactions between the peptide hydrogelator and the polymer are very crucial for the formation of hybrid hydrogel, which synergically induce the gelation at considerably low concentrations. A peptide hydrogelator can be easily obtained by aminolysis of alkyl-oilgo(γ-benzyl-l-glutamate) samples. Live/Dead assays indicate low cytotoxicity of the hybrid hydrogel toward HeLa cells. Combining the low-cost, scalable synthesis, and biocompatibility, the prepared peptide hydrogelator presents a potential candidate to expand the scope of polymer hydrogels for biomedical applications and also shows considerable commercial significance.

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Section: Resultsmentioning

confidence: 99%

Hybrid Hydrogels from Nongelling Polymers Using a Fibrous Peptide Hydrogelator at Low Concentrations

Wei

Lin

et al. 2022

Langmuir

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“…Thus, ideally, a careful combination of these two kinds of soft materials could enhance their advantages and moderate their weaknesses. In fact, several groups have shown that polymer additives may influence critical gelation concentration, gelation time, mechanical properties, or even biological activity of LMWGs [7–17] . In this field, different strategies can be used to combine LMWG and polymers.…”

Section: Introductionmentioning

confidence: 99%

“…In fact, several groups have shown that polymer additives may influence critical gelation concentration, gelation time, mechanical properties, or even biological activity of LMWGs. [7][8][9][10][11][12][13][14][15][16][17] In this field, different strategies can be used to combine LMWG and polymers. One of them consists of preparing interpenetrating networks (IPNs) in which a second network is formed through the voids of a preformed first network.…”

Section: Introductionmentioning

confidence: 99%

Effect of Hyaluronic Acid on the Self‐Assembly of a Dipeptide‐Based Supramolecular Gel

Giménez‐Hernández,

Falomir,

Escuder

2023

ChemBioChem

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The combination of polymers and low molecular weight (LMW) compounds is a powerful approach to prepare new supramolecular materials – i.e. hydrogels. Here we prepare two‐component hydrogels made by a well‐known and biologically‐active polymer, hyaluronic acid (HA), and a dipeptide‐based supramolecular gelator. We undertake a detailed study of different compositions including macroscopic (hydrogel formation, rheology) and micro/nanoscopic characterization (electron microscopy, X‐ray powder diffraction). We observe that the two components mutually benefit in the new material: a minimum amout of HA (1‐5 mol% of COOH groups) helps to reduce the polymorphism of the LMW component leading to reproducible hydrogels with improved mechanical properties; the LMW component network holds HA without the need of irreversible covalent crosslinking. These materials have a great potential for biomedical application as, for instance, extracellular matrix mimetics for cell growth. As a proof of concept, we have observed that this material is effective for cell growth in suspension and avoids cell sedimentation even in the presence of competing cell‐adhesive surfaces, which can be of interest for advanced cell delivery techniques.

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“…Aliphatic amide [29] or urea-coupled cyclohexane [30], peptides [31][32][33][34], and sugar-based derivatives with distinct helical structures [35][36][37] are typical examples of the former [38][39][40][41][42]. In contrast, cholesterol derivatives that aggregate due to crown moieties, π-π stacking, van der Waals forces, and/or solvophobic properties are a common example of the latter [43][44][45]. Among them, an intermolecular hydrogen-bonding interaction was utilized to prepare helical supramolecular gels.…”

Section: Introductionmentioning

confidence: 99%

In Situ Supramolecular Gel Formed by Cyclohexane Diamine with Aldehyde Derivative

et al. 2022

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Low-molecular-weight gels have great potential for use in a variety of fields, including petrochemicals, healthcare, and tissue engineering. These supramolecular gels are frequently metastable, implying that their properties are kinetically controlled to some extent. Here, we report on the in situ supramolecular gel formation by mixing 1,3-cyclohexane diamine (1) and isocyanate derivative (2) without any catalysis at room temperature in various organic solvents. A mixture of building blocks 1 and 2 in various organic solvents, dichloromethane, tetrahydrofuran, chloroform, toluene, and 1,4-dioxane, resulted in the stable formation of supramolecular gel at room temperature within 60–100 s. This gel formation was caused by the generation of urea moieties, which allows for the formation of intermolecular hydrogen-bonding interactions via reactions 1 and 2. In situ supramolecular gels demonstrated a typical entangled fiber structure with a width of 600 nm and a length of several hundred μm. In addition, the supramolecular gels were thermally reversible by heating and cooling. The viscoelastic properties of supramolecular gels in strain and frequency sweets were enhanced by increasing the concentration of a mixed 1 and 2. Furthermore, the supramolecular gels displayed a thixotropic effect, indicating a thermally reversible gel.

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Restricting Molecular Mobility in Polymer Nanocomposites with Self-Assembling Low-Molecular-Weight Gel Additives

Cited by 7 publications

References 21 publications

Hybrid Hydrogels from Nongelling Polymers Using a Fibrous Peptide Hydrogelator at Low Concentrations

Hybrid Hydrogels from Nongelling Polymers Using a Fibrous Peptide Hydrogelator at Low Concentrations

Effect of Hyaluronic Acid on the Self‐Assembly of a Dipeptide‐Based Supramolecular Gel

In Situ Supramolecular Gel Formed by Cyclohexane Diamine with Aldehyde Derivative

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