Restriction fragment length polymorphisms of L-myc and myb in human leukaemia and lymphoma in relation to age-selected controls

L-myc polymorphism in cancer patients, healthy blood donors and elderly, tumor-free individuals in Russia

“…However, all cohorts we have tested here demonstrated expected L-myc genotype frequencies. Consistent evidence for the usual occurrence of L-myc alleles in LC patients implies that, even if the S carriers are indeed more protected against smoking (Table II), this tolerance is not due to low LC risk.Contrary to previous publications (Chenevix-Trench et al, 1989;Young et al, 1994), we failed to obtain evidence for an association between the L-myc genotype and the chance to reach old age. This may be attributed to the fact that these reports described a highly heterogenous Australian white community, FIGURE 1 -L-myc genotyping by primers 177S and 177AS (a) and 267S and 267AS (b).…”

Increased frequency of the S allele of the L-myc oncogene in non-Hodgkin's lymphoma

“…The frequency of the L allele in our control population as well as the unselected controls of Chenevix-Trench et al (1989) is considerably higher than in the other reported studies of normals (Table II). The reason for this variation is unclear but may reflect differences in the ethnic composition of the various control groups.…”

“…Table II shows that Norwegians, Japanese, Indians, American Whites, English Caucasians and geriatric Australians of European descent have similar allele frequencies, whereas American Blacks have an increased frequency of the S allele. In contrast, our normal controls, as well as the unselected controls of Chenevix-Trench et al (1989), both of whom are of European descent, have an increased frequency of the L allele. Differing allele frequencies related to ethnicity are unlikely to be a factor in the increased frequency of the S allele in the NHL patients in our study because both our control and patient groups were Caucasians of European descent.…”

“…In addition, they found a significant difference in the genotype frequency between the geriatric population and the unselected controls and suggested that the LL homozygotes are less likely to reach old age. Neither our patient nor control group falls into the geriatric category described by Chenevix-Trench et al (1989) so we do not know if there is a reduced incidence of LL homozygotes in the New Zealand elderly population.…”

“…Digestion of DNA with EcoRI results in two alleles of 10 kb (L) and 6.6 kb (S). The S allele is reported to occur more frequently in male patients with bone and soft-tissue sarcomas (Kato et al, 1990), in oral cancer patients with poor to moderately differentiated tumours (Saranath et al, 1990) and in patients with leukaemia and lymphoma (Chenevix-Trench et al, 1989). Furthermore, an increased susceptibility to metastasis in lung (Kawashima et al, 1988), renal (Kakehi & Yoshida, 1989) and gastric cancer ) is associated with the presence of the S allele.…”