Restructuration kinetics of amphiphilic intraocular lenses during aging

Tortolano, Lionel; Saunier, Johanna; Hammami, Senda; Manerlax, Katia; Matmati, Houssem; Do, Bernard; Jubeli, Emile; Fattal, Elias; Yagoubi, Najet

doi:10.1016/j.colsurfb.2017.11.007

Cited by 4 publications

(14 citation statements)

References 99 publications

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“…A modification of the hydrophilic or hydrophobic character of a medical device surface could be related to changes in its biocompatibility and even cause adverse effects overtime. A recent study by Tortolano et al [37] highlighted that during polymer ageing, some PMMA-based ocular lenses could release additives leading to a modification in hydrophilicity of the implants surface and a potential cornea opacification. They also highlighted changes in the adhesion of a protein (fibronectin) related to a change in biocompatibility.…”

Section: Discussionmentioning

confidence: 99%

Do bevacizumab solutions interact with silicone or polyurethane catheters during an infusion through implantable venous access ports?

Tokhadzé

Chennell

Cueff

et al. 2019

J. R. Soc. Interface.

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This work aims to evaluate the possible impact of interactions between bevacizumab solutions and an implantable port equipped with a silicone or a polyurethane catheter after infusion through a complete infusion set-up in simulated use conditions. Physico-chemical and structural stability of bevacizumab solution was assessed by visual examination, subvisible particles counting, dynamic light scattering, size exclusion chromatography and ion exchange chromatography. Mechanical properties of the catheters were evaluated by measuring Shore A hardness, strain at break, strain at stress and Young's modulus. The physico-chemical surface state of the catheters was assessed by FTIR-ATR spectroscopy, scanning electron microscopy (SEM) and by water contact angle measurement. The analysis of the bevacizumab solution did not highlight any signs of instability or loss of active substance. Mechanical properties of both materials remained unchanged after the infusion. During material analysis, a decrease in water contact angle observed after infusion and was more pronounced for polyurethane catheters than for silicone, possibly due to bevacizumab adsorption or possible leachable extraction from the materials. Surface modifications were also noted at SEM. This study did not highlight any modifications that could alter the quality of the bevacizumab infusion, nor of the infusion catheter in polyurethane or silicone, despite a modification of surface hydrophilicity. Even if after a single infusion, implantable ports remained safe to use, they aim to be used for several infusion of various drugs during their lifetime, and further studies are needed to assess the impact of repeated infusions.

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Section: Discussionmentioning

confidence: 99%

Do bevacizumab solutions interact with silicone or polyurethane catheters during an infusion through implantable venous access ports?

Tokhadzé

Chennell

Cueff

et al. 2019

J. R. Soc. Interface.

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“…EnVista IOLs, that is packaged in saline has the higher rate of unbound degradation products. 27 The second factor is the outcome of new degradation products due to the photo-oxidation. These two factors are simultaneous.…”

Section: Thermogravimetric Analysismentioning

confidence: 99%

“…The first mass loss is due to the water, to the free degradation products or to those with weak bonds that disappeared between room temperature and 150 C before the thermal degradation of the polymer. 27 We related the differences in the first mass loss to the chemical composition of the implants. Indeed, EnVista implants are made from one hydrophilic acrylate, styrene and two hydrophobic acrylates including ethylene glycol phenyl ethyl acrylate.…”

Section: F I G U R Ementioning

confidence: 99%

“…Gradually the degradation products with the highest polarities migrated through the copolymer to the surface and got released in the surrounding middle of the polymer. 17,27 In the case of IOLs, this surrounding middle could be the aqueous humor. 27 At the same time, the copolymer becomes more cross-linked and less hydrated.…”

Section: F I G U R Ementioning

confidence: 99%

“…Photo-oxidation caused a surface reorganization due to both scissions and new polymerizations of the copolymer. 27 In the present study, we aged artificially four different brands of implants during 2, 5, 10, and 20 years. After which, we examined the surface and physicochemical properties using atomic force microscopy (AFM), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC) measurements.…”

mentioning

confidence: 99%

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Comparative stability of intraocular lenses during 2–20 years of artificial aging, potential effects in terms of biocompatibility

Tortolano

Mrad

Manerlax

et al. 2022

J of Applied Polymer Sci

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Intraocular lenses (IOLs) are worldwide used for cataract surgery. Mostly made of acrylate polymers, they can lead to an unexpected biocompatibility reaction such as posterior capsular opacification (PCO). Acrylate polymers suffer from both oxidative and heat/thermal aging that affect their properties. We examined the stability of four currently available acrylic IOLs, three hydrophobic and one amphiphilic, under artificial aging that simulate intraocular conditions from 2 to 20 years. Released degradation products were detected by reversed‐phase high performance liquid chromatography. Thermal properties were investigated using thermogravimetric analysis, and differential scanning calorimetry measurements. Surface topography was analyzed by atomic force microscopy. The effect on biocompatibility was estimated with protein sorption of the aged lenses. Both surface and thermal properties changed under aging. Surface roughness of implants increased under aging in a kinetic in two steps. The aging also changed the polymer structure. These changes lead to a variable release of degradation products according to the chemical design of the copolymer. Glass temperature transition (Tg) and thermal degradation stability also suffered from aging. The aging has led to significant changes in protein sorption affinity to IOL surfaces. For pure hydrophobic acrylic copolymer, stability was higher for copolymers containing at least one fluoro methacrylate. The amphiphilic polymer appeared to have a time‐dependent aging that can affect the implant flexibility and could impact late biocompatibility reaction and tolerance.

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Qualitative and quantitative analysis of leachables from dental composites under different extraction conditions using liquid chromatography coupled to mass spectrometry

Fučík,

Kejík,

Bystřický

et al. 2024

J of Applied Polymer Sci

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Dental caries is the most widespread form of disease, affecting over 90% of the global population. Amalgam fillings, which have been in use for nearly two centuries, will face an European Union ban by 2025. Although photocomposite fillings are a suitable alternative, health concerns persist because of potential substance release into the oral cavity. This study aimed to evaluate the release of photoinitiator substances and monomers from dental materials into various solvents at different temperatures over 30 days. Cylindrical specimens of the composite resins were submerged in different extraction solutions and incubated at 37 and 50°C. The findings demonstrated that both the extraction solvent and extraction temperature significantly influenced the quantity of leachables (p < 0.05). Furthermore, most leachables were released within the initial days, although some monomers continued to elute for over 30 days. The estimated daily intake was calculated for the worst‐case scenario, confirming the biocompatibility of the composite fillings. The weight loss of dental materials ranged up to 3.5% after 30 days, regardless of the extraction conditions and dental material (p > 0.05). In conclusion, this study contributes to filling several research gaps in the field by addressing the biocompatibility of various dental materials through quantitative and qualitative analyses supported by statistical evaluation.

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Restructuration kinetics of amphiphilic intraocular lenses during aging

Cited by 4 publications

References 99 publications

Do bevacizumab solutions interact with silicone or polyurethane catheters during an infusion through implantable venous access ports?

Do bevacizumab solutions interact with silicone or polyurethane catheters during an infusion through implantable venous access ports?

Comparative stability of intraocular lenses during 2–20 years of artificial aging, potential effects in terms of biocompatibility

Qualitative and quantitative analysis of leachables from dental composites under different extraction conditions using liquid chromatography coupled to mass spectrometry

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