Restructuring of amygdala subregion apportion across adolescence

Campbell, Claire; Mezher, Adam; Eckel, Sandrah P.; Tyszka, J. Michael; Pauli, Wolfgang M.; Nagel, Bonnie J.; Herting, Megan M.

doi:10.1016/j.dcn.2020.100883

Cited by 13 publications

(5 citation statements)

References 67 publications

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“…The human paralaminar region was also found to contain excitatory neurons that remain immature across postnatal life, providing a possible substrate for continued neuroplasticity in the amygdala ( Sorrells et al, 2019 ). As such, a recent cross-sectional structural MRI study by our team utilized a novel in vivo derived amygdala subnuclei atlas ( Tyszka and Pauli, 2016 ) to examine age-related differences in amygdala subnuclei volumes across adolescence ( N = 408, mean age = 14.12 years) ( Campbell et al, 2021 ). We found that the relative volume fraction of a number of specific nuclei within the amygdala, including the lateral, basolateral ventral and paralaminar subdivision (BLVPL), and central nucleus, increased with age in males.…”

Section: Introductionmentioning

confidence: 99%

“…In this study, our goal was to utilize NODDI to elucidate age-related differences in microstructural properties within amygdala subnuclei as well as amygdala white matter efferents in children and adolescents. While prior segmentation methods utilized ex vivo MRI and histological data to parcellate the amygdala based on post-mortem brains from older adults with an average age in the mid-60s ( Amunts et al, 2005 ; Saygin et al, 2015 ), new methods, such as the high-resolution probabilistic atlas (CIT168), allows for the segmentation of amygdala subnuclei in vivo in both adults ( Pauli et al, 2018 ; Tyszka and Pauli, 2016 ) and pediatric populations ( Campbell et al, 2021 ; Herting et al, 2020 ). We utilized each subject’s T1-weighted and T2-weighted images and the CIT168 atlas to segment the amygdala into 9 distinct bilateral subnuclei ( Pauli et al, 2018 ; Tyszka and Pauli, 2016 ) and developed a multi-fiber tractography protocol to delineate the three amygdala white matter tracts of interest, including the anterior commissure, stria terminalis, and ventral amygdalofugal pathway.…”

Section: Introductionmentioning

confidence: 99%

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Microstructural properties within the amygdala and affiliated white matter tracts across adolescence

et al. 2021

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The amygdala is a heterogenous set of nuclei with widespread cortical connections that continues to develop postnatally with vital implications for emotional regulation. Using high-resolution anatomical and multi-shell diffusion MRI in conjunction with novel amygdala segmentation, cutting-edge tractography, and Neurite Orientation Dispersion and Density (NODDI) methods, the goal of the current study was to characterize age associations with microstructural properties of amygdala subnuclei and amygdala-related white matter connections across adolescence ( N = 61, 26 males; ages of 8–22 years). We found age-related increases in the Neurite Density Index (NDI) in the lateral nucleus (LA), dorsal and intermediate divisions of the basolateral nucleus (BLDI), and ventral division of the basolateral nucleus and paralaminar nucleus (BLVPL). Additionally, there were age-related increases in the NDI of the anterior commissure, ventral amygdalofugal pathway, cingulum, and uncinate fasciculus, with the strongest age associations in the frontal and temporal regions of these white matter tracts. This is the first study to utilize NODDI to show neurite density of basolateral amygdala subnuclei to relate to age across adolescence. Moreover, age-related differences were also notable in white matter microstructural properties along the anterior commissure and ventral amydalofugal tracts, suggesting increased bilateral amygdalae to diencephalon structural connectivity. As these basolateral regions and the ventral amygdalofugal pathways have been involved in associative emotional conditioning, future research is needed to determine if age-related and/or individual differences in the development of these microstructural properties link to socio-emotional functioning and/or risk for psychopathology.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microstructural properties within the amygdala and affiliated white matter tracts across adolescence

et al. 2021

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“…Developmental studies have found that the amygdala volume and rsFC of amygdala subregions change with age, re ecting the immaturity of structure and function of amygdala in teenage years [27,28].…”

Section: Age Effects On Rsfc Of Speci C Amygdala Subregionsmentioning

confidence: 99%

Abnormal resting-state functional connectivity in subregions of amygdala in adults and adolescents with major depressive disorder

Guan,

Liu,

Zhou

et al. 2023

Preprint

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Background: The atypical symptoms of major depressive disorder (MDD) in adolescents suggest there may be differences in the pathophysiology between adolescents and adults with MDD. There is limited knowledge about the resting-state functional connectivity (rsFC) of amygdala subregions in MDD patients of different age groups, despite amygdala is believed to be critical in the pathophysiology. Methods: In the current study, 65 adolescents (46 with MDD and 19 controls) and 91 adults (35 with MDD and 56 controls) were recruited. A seed-based functional connectivity analysis was performed for each of the amygdala subregions. A 2×2 ANOVA was used to analyze the main effect of age, diagnosis, and their interaction on the rsFC of each subregion. Results: Significant main effect of age was revealed in the rsFC of bilateral centromedial (CM) subregions and right laterobasal (LB) subregion with several brain regions in the limbic system and frontoparietal network. Significant main effect of diagnosis showed MDD patients of different age showed a higher connectivity than controls between the right LB and left middle frontal gyrus (MFG). Conclusions: The rsFC of specific amygdala subregions with brain regions in limbic system and frontoparietal network is affected by age, indicating a distinct amygdala connectivity profile in adolescents. The decreased rsFC between the right LB and the left MFG in both adolescents and adults with MDD could potentially serve as a biomarker for early diagnosis of MDD.

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“…During this period, the human brain undergoes a substantial structural and functional reorganization [31]. Brain regions and systems that support resilience and related skills, such as the prefrontal cortex [32], amygdala, striatum [33][34][35], dopamine system [36], and hippocampus [37] all develop obviously and mature continuously during adolescence. The developmental period is also characterized by increased plasticity, during which neurocognitive networks evolve and are shaped through reciprocal interactions between the brain, body, behaviour, and the environment [38].…”

Section: Introductionmentioning

confidence: 99%

Psychological Resilience Interventions for Adolescents during the COVID-19 Pandemic

Xing

et al. 2023

Behavioral Sciences

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The COVID-19 pandemic has had severe mental health effects on adolescents. Psychological resilience is the ability to recover quickly from adversity and can help adolescents cope with the stress and dangers brought by the pandemic better. Therefore, the current study aimed to explore the developmental pattern of psychological resilience in adolescents and to find the sensitive period for psychological resilience intervention to promote resilience in adolescents during the pandemic. The study measured the psychological resilience of a total of 559 adolescents using the Connor-Davidson resilience scale (CD-RISC) in four grades: grade 7 and grade 8 in a junior high school, and grade 10 and grade 11 in a high school. It was found that the resilience level of the adolescents decreased in grade 10 and then increased significantly in grade 11 (F = 4.22, p = 0.006). A 4-week resilience intervention was conducted in the four grades using both psychological course training and physical training. The results revealed that the psychological course training was effective in promoting resilience in the 7th (F = 4.79, p = 0.03) and 8th (F = 4.75, p = 0.03) grades, but not in the 10th and 11th grades. The result suggests that the 7th and 8th grades may be a critical period for psychological resilience interventions for adolescents.

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Restructuring of amygdala subregion apportion across adolescence

Cited by 13 publications

References 67 publications

Microstructural properties within the amygdala and affiliated white matter tracts across adolescence

Microstructural properties within the amygdala and affiliated white matter tracts across adolescence

Abnormal resting-state functional connectivity in subregions of amygdala in adults and adolescents with major depressive disorder

Psychological Resilience Interventions for Adolescents during the COVID-19 Pandemic

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