Resultados de un programa psicoterapéutico de deshabituación tabáquica tras 12 meses de seguimiento

García, A. Vellisco; Gutiérrez, Francisco Javier Álvarez; Hernández, Teresa Elías; Romero, Julio Delgado; Marín, J. Toral; Sánchez, C. Bordoy; Gómez, J. Castillo

doi:10.1016/s0300-2896(01)75002-8

Cited by 3 publications

(3 citation statements)

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“…Effectiveness of multi-component programmes with standard pharmacological treatments (NST) for tobacco cessation in the general population is still unsatisfactory, with cessation rates at 1-year follow-up ranging from 30–40% [ 5 , 6 ]. These rates are even less successful in special populations such as psychiatric patients [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…To calculate the sample size we consider the tobacco cessation rate at 1 year follow-up as the main outcome variable. On the basis of published research data [ 5 , 6 ], we assume that this will be 35% in the control (NST) group, and we aim to detect a difference of 25% or more between any of the two groups (control and intervention). Published studies place placebo response at 10% [ 32 ].…”

Section: Methodsmentioning

confidence: 99%

“…The multi-component intervention includes first-line pharmacological treatments for tobacco such as Nicotine Substitution Therapy (NST) or bupropion, and psychological treatments. This intervention obtains a remission rate of 30–40% at 1-year follow-up [ 5 , 6 ]. As psychological therapy, cognitive-behavioural interventions, which can be administered on a group or individual basis, are used with follow-up sessions during the first year of abstinence.…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of topiramate for tobacco dependence in patients with depression; a randomised, controlled trial

et al. 2008

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BackgroundTobacco dependence management is a multi-component intervention that includes pharmacological treatments such as Nicotine Substitution Therapy (NST) or bupropion, and psychological therapy. There are some preliminary reports on topiramate efficacy for tobacco dependence. The aim of this study is to determine whether topiramate is as effective as the standard NST treatment for tobacco cessation at 1-year follow-up in patients with depression.Method/designDesign: A randomised, controlled trial involving two groups, one of which is the control group consisting of patients on the standard pharmacological treatment for tobacco cessation (NST) and the other is the intervention group consisting of patients on topiramate as pharmacological treatment.Setting: 29 primary care health centres in the city of Zaragoza, Spain.Sample: 180 patients, aged 18–65 years, diagnosed with major depression, smoke more than 20 cigarettes/day, who have voluntarily asked for tobacco cessation therapy.Intervention: A multi-component programme for tobacco cessation is offered to all of the patients in the study. This programme is made up of pharmacological therapy + group cognitive-behavioural therapy. Pharmacological therapy consists of NST for the control group and topiramate (200 mg/day) for the intervention group. Psychological therapy is made up of 16 sessions of manualised group therapy.Measurements: Cessation will be assessed by patient self-declared abstinence, expired air carbon monoxide levels, and cotinine levels in saliva. Questionnaires on tobacco dependence, anxiety, depression, impulsiveness and self-efficacy will be administered. The interviewers will not know which group the patient belongs to (blind). The assessments will be carried out at baseline, D (cessation day) -1, D+1, weeks 1, 2, 3, 4, 6, 8, 10 and 13, and months 4, 5, 6, 8, 10 and 12.Main variables: Tobacco cessation rates and tobacco dependence.Analysis: The analysis will be per intent to treat. We will use the general linear models of the SPSS version 15 statistical package, to analyse the effect of the treatment on the result variable (tobacco cessation rate).DiscussionIt is necessary to develop new and more effective pharmacological treatments for tobacco cessation. This randomised clinical trial will determine whether topiramate is effective for tobacco cessation in patients with depression.Trial registrationCurrent Controlled Trials ISRCTN93532081

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%