Résultats d'une étude multicentrique ouverte du traitement par Thérapie Photodynamique (Photofrin) de 49 malades avec un cholangiocarcinome

Boyer, J.; Maunoury, V.; Quentin, V.; Barthet, Marc; Laugier, R.; Prat, Frédéric; Fritsch, J.; Karsenti, David; Delcenserie, Richard; Vinel, Jean Pierre; Raffanel, C; Bauret, P.; Bulois, P.; Subtil, C.; Laquière, A.; Boytchev, Isabelle; Cochelard, D.

doi:10.1055/s-2007-974249

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, Boyer et al. 16 reported the results of a multicenter study including 49 patients with unresectable CC. Nine of these were treated with PDT and biliary drainage in our centre 28 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Biliary drainage, photodynamic therapy and chemotherapy for unresectable cholangiocarcinoma with jaundice

Fuks

Bartoli

Delcenserie

et al. 2009

J of Gastro and Hepatol

View full text Add to dashboard Cite

Background and Aim: The combination of photodynamic therapy and biliary stenting seems to be beneficial in the palliative treatment of unresectable cholangiocarcinoma. We aimed to assess the accuracy of photodynamic therapy in a single centre. Methods: Fourteen selected patients, with jaundice related to unresectable cholangiocarcinoma, underwent photodynamic therapy and biliary stenting (with or without chemotherapy). Photofrin was injected intravenously (2 mg/kg) 2 days before intraluminal photoactivation. In case of malignant progression, photodynamic therapy was repeated. The outcome parameters were overall survival and quality of life. Results: There were eight men and six women (median age: 67 [42-81]). Unresectability was related to a low Karnofski index (n = 2), peritoneal carcinomatosis (n = 4), vascular involvement (n = 3), invasion of the hepatoduodenal ligament (n = 2) and an under-sized liver remnant (n = 3). Biliary stenting was efficient (Ն 50% total bilirubin) in 78.5% of cases. Eight patients developed cholangitis. The mean number of photodynamic therapy procedures was two (1-4). Six (43%) patients needed Ն 2 procedures. No severe toxicity was noted. Photodynamic therapy improved the Karnofski index in 64% of cases. Six (42.8%) patients received concomitant chemotherapy (gemcitabine). The median survival time was 13.8 [0.7-29.2] months. The 3-, 6-and 12-month survival rates were 85%, 77% and 77%, respectively. Conclusion: These results confirm the beneficial effect of biliary drainage, photodynamic therapy and chemotherapy for unresectable cholangiocarcinoma in selected patients with jaundice.

show abstract

Section: Discussionmentioning

confidence: 99%

“…In case of recurrence of stenosis, a new PDT procedure was performed. Of the patients treated with PDT in our centre, nine were included in a French, nationwide, multicenter, open‐label study 16 …”

Section: Methodsmentioning

confidence: 99%