Résultats et place du Fibroscan® dans le diagnostic non invasif de la fibrose hépatique

Nguyen‐Khac, Eric

doi:10.1016/j.revmed.2006.10.329

Cited by 8 publications

(4 citation statements)

References 72 publications

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“…Liver stiffness was measured using a transient elastography (TE) device (Fibroscan, Echosens, Paris, France). TE is a noninvasive method for measuring liver stiffness reflecting the degree of fibrosis (29)(30)(31). Liver stiffness values below 6.0 kPa were considered as normal (32).…”

Section: Outcome Measuresmentioning

confidence: 99%

Long-Term Outcomes After Autologous Intestinal Reconstructive Surgery in Children With Short Bowel Syndrome

Pajunen

Mutanen

Kivisaari

et al. 2023

Journal of Pediatric Gastroenterology &Amp; Nutrition

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Objectives: Autologous intestinal reconstructive (AIR) surgery is frequently utilized in the management of pediatric short bowel syndrome (SBS). However, little is known about the long-term sequela of these procedures. Methods: We undertook a retrospective follow-up study addressing parenteral nutrition (PN) dependence, nutritional status, intestinal morbidity, and related complications in SBS patients having undergone AIR surgery (SBS-AIR, n = 19). We compared results with conservatively treated control SBS patients (SBS-C, n = 45). Eligible patients were identified from our institutional intestinal failure registry during 1985–2019. Results: After median 11.4 follow-up years, 42% of SBS-AIR patients received PN in relation to 36% in SBS-C group (P = 0.6210), and overall PN duration was significantly longer (35.4 vs 10 months, P = 0.0004) in SBS-AIR group. Although symptoms of intestinal dysfunction improved in majority (62%) of patients after AIR surgery, their symptoms remained more frequent and severe at latest follow-up compared to SBS-C group (39% vs 5%, P = 0.0015). Although bacterial overgrowth was more frequent in SBS-AIR group (53% vs 24%, P = 0.0416), latest endoscopy findings and fecal calprotectin levels as well as occurrence of anastomotic/staple line ulcerations were comparable between groups. Histological liver steatosis (50% vs 18%, P = 0.042) and impaired bone health (26% vs 6.7%, P = 0.042) were more frequent in SBS-AIR patients. Conclusions: While AIR surgery improved gastrointestinal symptoms and transition to enteral autonomy in majority of patients, a noteworthy proportion of them continued to suffer from clinically significant intestinal dysfunction and related complications. Close long-term follow-up of pediatric AIR surgery patients is mandatory.

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Section: Outcome Measuresmentioning

confidence: 99%

Long-Term Outcomes After Autologous Intestinal Reconstructive Surgery in Children With Short Bowel Syndrome

Pajunen

Mutanen

Kivisaari

et al. 2023

Journal of Pediatric Gastroenterology &Amp; Nutrition

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“…Lawson-Ananissoh et al in 2018 [6] conducted a study in which liver fibrosis was assessed in patients with viral hepatitis B using non-invasive methods such as APRI, Fibrosis-4 (FIB-4), fibrotest and fibroscan. Fibroscan has some limitations, in particular its use is limited to measuring hepatic elasticity, without any morphological analysis of the liver, and also obesity, depending on the patient's body mass index (BMI) and the type of probe used [7].…”

Section: Introductionmentioning

confidence: 99%

“…Two-dimensional elastography using the Shearwave technique (2D-SWE) is a new, innovative technique. Several studies around the world and in Africa have already shown very promising results in the assessment of liver fibrosis [7] [8] [9]. Screening for fibrosis in people with chronic liver disease is a major challenge.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Assessment of Liver Fibrosis by Elastography in Patients with Chronic Liver Disease: A Cross-Sectional Study in Lom&#233; (Togo)

Dagbe,

N’timon,

Ekembe

et al. 2024

OJRad

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Aim: To describe the two-dimensional elastographic profile according to the Shearwave (2D-SWE) technique in patients with chronic liver disease in Lomé. Materials and method: Cross-sectional, descriptive study conducted over seven month at the Autel d'Elie Clinic in Lomé, from January to August 2022, on adult patients with chronic liver disease who underwent abdominal ultrasound coupled with two-dimensional elastography. Results: The sample size was 54 patients. The mean age of the patients was 33 ± 12 years, with extremes of 18 and 66 years. Patients aged 30 years or less accounted for 48.1% (n = 26). All patients (n = 54) had at least one transaminase assay with a mean of 69.3 ± 78.3 IU/l (AST) and 59.3 ± 82.8 IU/l (ALT). There was no statistically significant association between the biological parameters and the presence of fibrosis. Viral liver disease was the main cause, accounting for 81.5% (n = 44) of cases, with no significant association with the degree of fibrosis. Ultrasound revealed a dysmorphic liver (57.4%; n = 31) and portal hypertension (18.5%, n = 10). Fibrosis stages F1, F2 and F4 accounted for (48.1%, n = 26), (24.1%, n = 13) and (13%, n = 7) of cases respectively. Liver dysmorphia was significantly associated with the presence of fibrosis (p = 0.012) and portal hypertension was significantly associated with the degree of fibrosis (p = 0.0063). Conclusion: Assessment of liver fibrosis in patients with chronic liver disease using 2D-SWE elastography is essential for patient follow-up.

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“…[ 1 ] An accurate estimation of the degree of liver fibrosis is crucial for prognostication and clinical decision making. [ 2 , 3 ] To date, a liver biopsy has been used as a primary diagnostic tool in this context. However, its invasiveness, high costs, variability in interpretation, sampling error, and difficulty with continued observation and monitoring of fibrosis limit the use of a liver biopsy.…”

Section: Introductionmentioning

confidence: 99%

Feasibility and Efficacy of Transient Elastography using the XL probe to diagnose liver fibrosis and cirrhosis

et al. 2018

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Background:Transient elastography (TE) has been validated as an effective noninvasive tool for the assessment of liver fibrosis. The XL probe is a new probe that was initially designed for use in patients with obesity. A meta-analysis was performed to assess the feasibility and efficacy of TE using the XL probe.Methods:In September 2016, we systematically searched the PubMed and Science Direct search engines. The feasibility of TE was evaluated based on the failure rate and the results of the unreliable liver stiffness measurement (LSM). The efficacy of TE was measured using sensitivity, specificity, and summary receiver-operating characteristic as measures/indices assessed in different stages of fibrosis. Heterogeneity was measured using the chi-squared test and the Q-statistic. We used the 95% confidence interval (95% CI) as an effect measure.Results:We included 8 studies in the meta-analysis. When the XL was compared to the M probe, the former showed a lower risk of failure rate [relative risk (RR) 0.24, 95% CI 0.14–0.38]. In patients with a body mass index ≥30 kg/m2, the XL probe showed a statistically significantly lower risk of failure rate (RR 0.16, 95% CI 0.08–0.32) but no significant improvement (RR 0.76, 95% CI 0.50–1.16) in the unreliable LSM result. In patients showing liver fibrosis stage ≥F2, the XL probe showed a sensitivity of 0.56 (95% CI 0.39–0.72), specificity of 0.71 (95% CI 0.61–0.79), and an area under the curve (AUC) of 0.71. The results observed in patients with liver fibrosis stage F4 were more promising with a sensitivity of 0.84 (95% CI 0.76–0.90), specificity of 0.78 (95% CI 0.70–0.84), and an AUC of 0.88.Conclusion:TE using the XL probe demonstrates significant diagnostic utility in patients with liver fibrosis and is likely to be more reliable than the M probe in patients with obesity. Large prospective multicenter studies are, however, necessary to establish the new cut-off values to be used for the XL probe in patients with obesity.

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Résultats et place du Fibroscan® dans le diagnostic non invasif de la fibrose hépatique

Cited by 8 publications

References 72 publications

Long-Term Outcomes After Autologous Intestinal Reconstructive Surgery in Children With Short Bowel Syndrome

Long-Term Outcomes After Autologous Intestinal Reconstructive Surgery in Children With Short Bowel Syndrome

Quantitative Assessment of Liver Fibrosis by Elastography in Patients with Chronic Liver Disease: A Cross-Sectional Study in Lom&#233; (Togo)

Feasibility and Efficacy of Transient Elastography using the XL probe to diagnose liver fibrosis and cirrhosis

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Résultats et place du Fibroscan® dans le diagnostic non invasif de la fibrose hépatique

Cited by 8 publications

References 72 publications

Long-Term Outcomes After Autologous Intestinal Reconstructive Surgery in Children With Short Bowel Syndrome

Long-Term Outcomes After Autologous Intestinal Reconstructive Surgery in Children With Short Bowel Syndrome

Quantitative Assessment of Liver Fibrosis by Elastography in Patients with Chronic Liver Disease: A Cross-Sectional Study in Lom&amp;#233; (Togo)

Feasibility and Efficacy of Transient Elastography using the XL probe to diagnose liver fibrosis and cirrhosis

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Quantitative Assessment of Liver Fibrosis by Elastography in Patients with Chronic Liver Disease: A Cross-Sectional Study in Lomé (Togo)