Results and Possible Developments of the Clinical Use of S-Adenosyl-L-Methionine (SAMe) in Psychiatry

Agnoli, A.; Andreoli, V. M.; Casacchia, M; Maffei, F.; Fazio, C.

doi:10.1007/978-3-642-88516-7_18

Cited by 12 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effects of the nyctohemeral rhythm in the levels of SAMe on the biosynthesis of the indolealkyamines 5-hydroxy-N,N-dimethyltryptamine, 5-methoxy-N,Ndimethyltryptamine, andN,N-dime thyltryptamine within the pineal gland are at present unknown . These compounds are of particular interest (Sitaram and McLeod, 1990) because they have been detected in human body fluids (Raisenen and Karkkainen, 1979;Sitaram et al, 1983;Karkkainen et al, 1988) and are implicated in the ability of exogenously administered SAMe (and its precursor methionine) to exacerbate schizophrenic symptoms (Cohen et al, 1974;Agnoli et al, 1978) and to induce states ofhypomania (Carney et al, 1988) . Because of the presence of high concentrations of SAMe, 5-HT, and 5-methoxytryptamine, the pineal gland has been suggested as a potential site for the synthesis of the psychotomimetic indolealkylamines (Guchhait, 1976;Hardeland et al, 1993) .…”

Section: Effect Of Administration Of the /3-adrenoreceptor Antagonistmentioning

confidence: 99%

Nyctohemeral Rhythm in the Levels of S‐Adenosylmethionine in the Rat Pineal Gland and Its Relationship to Melatonin Biosynthesis

Sitaram

Traut

et al. 1995

Journal of Neurochemistry

View full text Add to dashboard Cite

Liquid chromatographic techniques that permit the simultaneous analysis of S‐adenosylmethionine, melatonin, and its intermediary metabolites N‐acetyl‐5‐hydroxytryptamine and 5‐hydroxytryptamine within individual pineal glands have been developed. S‐Adenosylmethionine has been shown to undergo a marked nyctohemeral rhythm in the pineal gland of the rat, with maximal levels occurring during the light period and minimal levels during the dark period. Detailed studies of the temporal relationships between the levels of S‐adenosylmethionine and those of melatonin and its intermediary metabolites suggest that an association exists between the levels of S‐adenosylmethionine and the status of the biosynthesis of melatonin. Exposure of animals to continuous light and the administration of the β‐adrenoreceptor antagonist propranolol were both found to inhibit the induction of melatonin synthesis and prevent the reduction in the levels of S‐adenosylmethionine during the dark period. As a corollary the induction of melatonin biosynthesis following the administration of the β‐adrenoreceptor agonist isoproterenol during the light period was accompanied by a marked decrease in the levels of S‐adenosylmethionine in the pineal gland. The significance of the link between the nyctohemeral rhythms in the levels of S‐adenosylmethionine and the biosynthesis of melatonin in the pineal gland is discussed in the context of the therapeutic efficacy of S‐adenosylmethionine as an antidepressant.

show abstract

Section: Effect Of Administration Of the /3-adrenoreceptor Antagonistmentioning

confidence: 99%

Nyctohemeral Rhythm in the Levels of S‐Adenosylmethionine in the Rat Pineal Gland and Its Relationship to Melatonin Biosynthesis

Sitaram

Traut

et al. 1995

Journal of Neurochemistry

View full text Add to dashboard Cite

show abstract

S-adenosyl methionine (SAMe) for depression in adults

Galizia

Oldani

Macritchie

et al. 2016

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

Given the absence of high quality evidence and the inability to draw firm conclusions based on that evidence, the use of SAMe for the treatment of depression in adults should be investigated further. Future trials should be in the form of large randomised controlled clinical trials of high methodological quality, with particular attention given to randomisation, allocation concealment, blinding and the handling of missing data. Comparator antidepressants from all classes should be used. Adverse events should be detailed for each participant, bearing in mind that induction of mania is of particular interest.

show abstract

Noradrenergic and Cardiovascular Effects of Chronic S-Adenyosyl-Methionine in Healthy Volunteers

Sherer¹,

Rudorfer²,

Cantoni³

et al. 1986

Biological Methylation and Drug Design

View full text Add to dashboard Cite

Results and Possible Developments of the Clinical Use of S-Adenosyl-L-Methionine (SAMe) in Psychiatry

Cited by 12 publications

References 7 publications

Nyctohemeral Rhythm in the Levels of S‐Adenosylmethionine in the Rat Pineal Gland and Its Relationship to Melatonin Biosynthesis

Nyctohemeral Rhythm in the Levels of S‐Adenosylmethionine in the Rat Pineal Gland and Its Relationship to Melatonin Biosynthesis

S-adenosyl methionine (SAMe) for depression in adults

Noradrenergic and Cardiovascular Effects of Chronic S-Adenyosyl-Methionine in Healthy Volunteers

Contact Info

Product

Resources

About