Results and prognostic factors in stage IE-IIE primary gastric lymphoma after gastrectomy

Rodríguez‐Sanjuán, Juan Carlos; Álvarez-Cañas, Concepción; Gutiérrez, Fernando Casado; Garcı́a-Castrillo, Luis; Casanova, Daniel; Val-Bernal, J. Fernando; Naranjo, Angel

doi:10.1016/s1072-7515(98)00302-0

Cited by 10 publications

(13 citation statements)

References 40 publications

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“…Concerning non-FC tumor features, we have not found any prognostic value for wall invasion nor histologic type by contrast with other works (7,9,10) and even our previous analysis (6). The latter could be due to a longer follow-up and the inclusion of new patients.…”

Section: Discussioncontrasting

confidence: 99%

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Prognostic value of flow cytometry in surgically treated primary gastric lymphoma

Fernández

Rodríguez‐Sanjuán

Mayorga

et al. 2006

Rev. esp. enferm. dig.

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Aim: to investigate whether flow cytometry could help to define the optimal therapeutic strategy of primary gastric lymphomas.Material and method: retrospective study of 46 patients having primary gastric lymphoma -according to Dawson criteria-in Ann Arbor stage I E and II E , who were surgically treated. From selected paraffin-embedded tissue blocks of the tumor, DNA content was studied by flow cytometry (FC). Other pathological tumor features were analysed by hematoxiline-eosine and Giemsa stains as well as immunohistochemical study; any possible influence on postoperative survival was investigated through statistical analysis.Results: the DNA ploidy pattern was diploid in 40 cases (87%) and aneuploid (hyperdiploid) in 6 (13%). Postoperative survival probability (PSP) was 62.7% at 5 years. Statistical analysis showed significant prognostic value for Ann Arbor classification -with higher PSP for stage I E (p = 0.009)-and FC parameters: diploid tumors had higher PSP than aneuploid tumors. Also tumors having S-phase (p = 0.044) or G2-M phase values (p = 0.023) under the respective mean values had higher PSP. No influence on PSP was found for wall invasion, Helicobacter pylori infection, Isaacson's histologic type or resection margin involvement. No significant relationship was appreciated between Isaacson's histologic type and DNA ploidy patterns.Conclusion: FC could be useful in assessing gastric lymphoma prognosis.

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Section: Discussioncontrasting

confidence: 99%

“…Among these factors are the clinical stage, high-grade histologic type, serosal involvement, or proliferating cell nuclear antigen (PCNA) expression (4)(5)(6)(7)(8)(9)(10)(11). Flow cytometry (FC) is a quantitative method of DNA content assessment.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of flow cytometry in surgically treated primary gastric lymphoma

Fernández

Rodríguez‐Sanjuán

Mayorga

et al. 2006

Rev. esp. enferm. dig.

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“…Kodera et al [28] showed that there was no difference in the survival rates of 45 patients with subtotal gastrectomy and 37 patients with total gastrectomy among 82 patients with primary gastric lymphoma in stages I and II. Similar results were reported by Rodriguez-Sanjuan et al [29] , and by Colucci et al [30] . Bozer et al [31] reported better survival rates in 13 patients with stages I and II primary gastric lymphoma who received total gastrectomy than in 24 patients who underwent subtotal gastrectomy.…”

Section: Discussionsupporting

confidence: 92%

Clinicopathologic features of surgically resected primary gastric lymphoma

Kong¹,

Kim²,

Park³

et al. 2004

WJG

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AIM:To analyze the clinicopathologic characteristics of surgically resected gastric lymphoma patients. METHODS:We retrospectively analyzed 57 surgically resected gastric lymphoma patients, dividing them into 2 subgroups: Low grade MALToma (the LG group), High grade MALToma and Diffuse large B cell lymphoma (the HG group). RESULTS:The numbers of patients were: 20 in the LG group, 37 in the HG group. The diagnostic rate of gastroscopy was 34.8% at primary diagnosis and 50% including differential diagnoses. The positive rates of H pylori were similar between the 2 groups (68% vs 77%). Multiple lesions were found in 19.3%. The proportion of mucosal and submucosal lesions was 80.0%(16/20) in the LG group, and 24.3%(9/37) in the HG group (P<0.001). Lymph node invasion rates were 10.5%(2/19) in the LG group and 44.1%(15/34) in the HG group (P=0.031). The numbers of recurred patients were none in the LG group, and 8 in the HG group. By univariant analysis, group (P=0.024) and TNM stage (stage I, II vs stages III, IV, P=0.002) were found to be the significant risk factors. There was a tendency of higher recurrence rate in the subtotal gastrectomy group than in the total gastrectomy group (P=0.50). CONCLUSION:The HG groups had a more advanced stage and a higher recurrence rate than the LG group. Although there was no difference between subtotal and total gastrectomies, more careful assessments of multiplicities and radical resections with lymph node dissections seem to be needed because of multiplicity and LN invasion even in LG group.Kong SH, Kim MA, Park DJ, Lee HJ, Lee HS, Kim CW, Yang HK, Heo DS, Lee KU, Choe KJ. Clinicopathologic features of surgically resected primary gastric lymphoma.

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“…A retrospective analysis from The Royal Marsden Hospital (London, UK) failed to show survival advantages when results of chemotherapy were compared to surgery followed by chemotherapy in a series of patients with mostly diffuse large B-cell lymphoma [14]. Similar results from retrospective analyses conducted from Spain and Greece have been noted [7,12].…”

Section: Diffuse Large B-cell Gastric Lymphomamentioning

confidence: 72%

“…• The use of surgery as primary therapy for gastric diffuse large B-cell lymphoma is controversial, but it is advocated by some groups. Postoperative mortality is less than 5% in recent series [7][8][9][10][11][12]. In these trials, 5-year survival rates have averaged 50% to 75%, although interpretation of results is difficult because of differences in selection criteria, the inclusion of patients with low-grade and aggressive histology, and the use of postoperative chemotherapy or radiation in many series.…”

Section: Surgerymentioning

confidence: 99%

Gastrointestinal lymphoma

Bierman

2003

Curr. Treat. Options in Oncol.

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The ability to make treatment recommendations for patients with gastrointestinal lymphoma is hampered by a lack of prospective trials and by a lack of uniformity in classification and staging. Patients with gastric diffuse large B-cell lymphoma have traditionally been treated with surgery and many physicians continue to recommend this approach. However, recent data suggest that these patients can be treated with combination chemotherapy regimens in the same manner as patients with nodal presentations of diffuse large B-cell lymphoma. There is evidence to suggest that adjuvant radiotherapy may improve the outcome for these patients. The recognition that extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue is a distinct clinicopathologic entity and the elucidation of the pathogenic role of Helicobacter pylori has revolutionized the treatment of these gastric lymphomas. Patients with localized disease should be managed with antibiotic therapy initially. Radiation therapy is extremely effective for these patients, but it should probably be reserved for patients who fail anti-H. pylori treatment.

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Results and prognostic factors in stage IE-IIE primary gastric lymphoma after gastrectomy

Cited by 10 publications

References 40 publications

Prognostic value of flow cytometry in surgically treated primary gastric lymphoma

Prognostic value of flow cytometry in surgically treated primary gastric lymphoma

Clinicopathologic features of surgically resected primary gastric lymphoma

Gastrointestinal lymphoma

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