Results comparing hyperthermia and radiation versus radiation alone in treatment of 79 patients with stage iiib carcinoma of the uterine cervix

Hornback, Ned B.; Shidnia, Homayoon; Shupe, Robert E.; Reddy, Sudhakar; Marshall, Carol; Baker, Rebecca

doi:10.1016/0360-3016(80)90480-0

Cited by 10 publications

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“…Bisher liegen nur einzelne Berichte über die Hyperthermiebehandlung von gynäko logischen Tumoren vor (36,37,42 …”

Section: Gynäkologische Tumorenunclassified

Palliative Radiotherapie mit und ohne Hyperthermie in der Gynäkologie

Herbst¹

1983

Geburtsh Frauenheilk

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There can be no doubt as to the effectivity of radiotherapy in the treatment of advanced cancers, local recurrences and metastases of gynaecological tumours. The following rates of remission can be achieved: skeletal metastases 80% brain metastases 70% liver metastases 40-50% local recurrences of cancer of the breast 80% cervical carcinomas 50-80% The combined treatment of hyperthermia and radiotherapy improves the local control rate. This has been confirmed for superficially located tumours. The local tolerance of hyperthermia is excellent and there are practically no complications. The side effects of radiotherapy are not enhanced by hyperthermia.

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“…Bisher liegen nur einzelne Berichte über die Hyperthermiebehandlung von gynäko logischen Tumoren vor (36,37,42 …”

Section: Gynäkologische Tumorenunclassified

Palliative Radiotherapie mit und ohne Hyperthermie in der Gynäkologie

Herbst¹

1983

Geburtsh Frauenheilk

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The role of the radiation oncologist in the management of gynecologic cancer

Kapp¹

1983

Cancer

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Optimal management of patients with gynecologic malignancies requires a multidisciplinary approach with close cooperation between the primary care physician, the gynecologic oncologist and the radiation therapist. In order to obtain maximum survival rates with minimal morbidity, treatment should be based on a detailed knowledge of tumor localization, potential sites of occult spread, and tumor–host interactions. A careful delineation of patterns of recurrence will permit the identification of patients at increased risk for treatment failure and will aid in the design of alternative treatment protocols tailor‐made to control potential site(s) of tumor spread. The technological advances in radiation oncology and their influence on survival rates are presented, with illustrations taken from the literature and from the recent results of the Patterns of Care Study for treatment of carcinoma of the cervix. The role of radiation therapy in the treatment of carcinomas of the cervix, uterus, and the epithelial tumors of the ovary are reviewed, emphasizing treatment protocols based on consideration of technical, tumor, and host factors. Ongoing clinical research trials and potential areas for further improvement in the management of gynecologic malignancies are discussed.

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Concomitant continuous infusion chemotherapy and radiation

Rotman¹,

Aziz²

1990

Cancer

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Attempts to duplicate the cytotoxic effect of oxygen on radioresistant tissues spurred a search by radiation oncologists for other radiosensitizing techniques. This led to large-scale investigations using neutrons and other heavy particle radiations, hyperthermia, altered fractionation schedules, and the systemic use of the halogenated pyrimidines and the electron-affinic compounds. Unfortunately, the promise that the nitroimidazole compounds would selectively sensitize the radioresistant tumor cells and prove to be an effective systemic agent has not been borne out in clinical trials thus far. Existing pharmokinetic and cytokinetic studies have suggested that continuous infusion chemotherapy given concomitantly (CCIC) with irradiation (RT) acts synergistically, resulting in a significant increase in tumor cell killing. These observations have been supported by clinical research studies treating certain epithelial cancers that have resulted in considerably higher locoregional control rates and improved survival. Although initially used in treatment of only advanced or inoperable epithelial carcinomas, CCIC and RT are now being employed in the treatment of lower staged cancers as an organ-sparing procedure. Carcinoma of the anus treated by anteroposterior (AP) resection alone have reported 5-year survival rates of 30% to 60%. CCIC and RT using 5-fluorouracil (5-FU) and mitomycin C have achieved a local control rate of 90% to 100% and a 5-year survival rate of 80% to 86% with sphincter preservation in 90% of these cases. The 5-year survival rate in advanced urinary bladder carcinoma is 25% to 30% for either radiation or surgery and 42% when combined in a preoperative radiation schedule. Using 5-FU CCIC and RT, the local control rate of transitional cell carcinoma of the bladder has been 71% to 86% with a 5-year survival of 62%. 5-FU CCIC and cisplatin and RT used in the treatment of Stages III and IV carcinoma of the cervix yields a locoregional control of 74% compared with the radiation alone local control of 63% for Stage III and 30% for Stage IV disease. Advanced head and neck and paranasal sinus carcinomas treated by cisplatin CCIC and RT show improved tumor clearance even in the presence of bone destruction. A complete response rate of 87% has been reported with the use of cisplatin CCIC and hyperfractionated radiation. Hyperfractionated radiation also appears to improve the local control of advanced head and neck cancers over patients treated with single fractions of radiation with 66% surviving at 22 months.(ABSTRACT TRUNCATED AT 400 WORDS)

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Results comparing hyperthermia and radiation versus radiation alone in treatment of 79 patients with stage iiib carcinoma of the uterine cervix

Cited by 10 publications

References 0 publications

Palliative Radiotherapie mit und ohne Hyperthermie in der Gynäkologie

Palliative Radiotherapie mit und ohne Hyperthermie in der Gynäkologie

The role of the radiation oncologist in the management of gynecologic cancer

Concomitant continuous infusion chemotherapy and radiation

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